DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mdr50 and mam1

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_001018819.2 Gene:mam1 / 2540405 PomBaseID:SPBC25B2.02c Length:1336 Species:Schizosaccharomyces pombe


Alignment Length:1401 Identity:362/1401 - (25%)
Similarity:619/1401 - (44%) Gaps:203/1401 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 KLEDSDRDRKSFEPNKSK-KKSKHD-----------------------ESDASDE--------ED 60
            :.|.:..|..|:.|.||. ::.||:                       .||..|.        :|
pombe    11 QFEHASIDPPSYSPQKSSFEEKKHNFSITNKSLETLRSQESPCSTTFPVSDRKDALLNIPTVVDD 75

  Fly    61 GSQYHEDVKQVS----YFQLFRYATKKDRAL----YVIGLLSAVATGLTTPANSLIFGNL---AN 114
            ..|:.|::..||    :|.||.::   |..|    .:...|||....|.|.....:|..|   |.
pombe    76 EFQHTEELAGVSSWSDFFYLFHFS---DIPLIFGTLIFTCLSAALEPLMTWTTGKVFDALSQYAT 137

  Fly   115 DMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCS--------YLSI------ 165
            ..|.||.:            ||.:..:     ||..|..|:...|.|        |||.      
pombe   138 SQITLGKM------------ISLINFN-----SLLITIFGLASCVFSFGVRFLWQYLSAIAGKRA 185

  Fly   166 --TCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHY 228
              .||:      :|:.:|..|.|:..        ::||.|.| ::..:...|..::..:......
pombe   186 RSLCFH------VLSSKSSTFYSLTE--------SKSGLVNS-VDRCIQFYEKSISLPMFHIAEN 235

  Fly   229 LVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGI 293
            |...:..|:::|...|.|:||.|.|.|:..:.:|.:....|...:|:......||.:.|.::|.|
pombe   236 LAISLSCLIISFRYSWSLTLVVLASYPIIILVVGFINSFLSSAYEKDRKSSEKAASILEKSISAI 300

  Fly   294 RTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYH 358
            :||.....:..|...:.:....:....::.:.......|:..||:|:.:....|:       |.|
pombe   301 QTVIFHSMQDTEYRYFADACSTSSKSFLRFSFLDAFQGGVSQFFLYSVFFQGLWF-------GNH 358

  Fly   359 EPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEI-NPIDGEGK 422
            ....:..:.|.::|||.|.:..:.::....|.|.  .:.||..:.  |.|:.:.|. :||:. .|
pombe   359 LATTKRVNVGQVVTVFGSCLSVASSLQQILPAIP--DLIKGKFSS--HFIKTLCESHDPIEA-AK 418

  Fly   423 KLNEPLTTIEFK------EVEFQYPTRPE--VSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLV 479
            :....:.:|.|:      .|.|.||:|.|  .|::| :::.|..|:.|.::||||.||||.|.|:
pombe   419 RSAAKIKSISFERGFRFDNVSFAYPSRDENLFSLIN-VSVFIPFGELVHIIGPSGSGKSTFISLL 482

  Fly   480 QRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAA 544
            .|::.|..||:..:...|:::|.:.|.|.|.:|.|:|::|..:|.|||....|:|:..:.|....
pombe   483 LRYFSPTYGNIYLDDFPLEEIDEHVLGSTITLVCQQPVIFDMTIRENIIMRNENASESDFEEVCR 547

  Fly   545 AANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQ 609
            .|....|.....:.|||...|  |.|||||:||||:||||:||.|||:|||.|||||..::..|.
pombe   548 LALVDEFALTFDQSYDTPCKE--ASLSGGQQQRIALARALLRDTEILILDEPTSALDPITKNLVM 610

  Fly   610 AALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDG 674
            .|:.....|:||:::.|.:|.:...:.::||:||.:::....:||:..:|...|:      ..|.
pombe   611 DAIRAHRKGKTTLVITHDMSQINNDELVLVIDKGHLIQRCARKELVLFEDFENNV------SIDE 669

  Fly   675 SVLSPTGDIYKNFDIKDED----------EEEIKVLSE------------DEDEDVMVTDEKNKK 717
            .||....|  ..|.:.:|:          .|....||.            |.:...:|:..|..:
pombe   670 KVLKEEAD--NPFILPNEESLLEKYWINYNESFSQLSRESLFTSLESPFTDIESPTIVSRRKIVE 732

  Fly   718 KKKKKVK----------------DPNEVKPML-----EVMKMNKPEWLQIAVGCISSVIMGCAMP 761
            ::|.:::                |..|....|     .:.|:.|..|. ..:|.::|:|.|.::|
pombe   733 QRKLRMEKESFQETNVDQTFHLFDDKEHACSLTLIFKSIWKVKKLRWF-FLLGLLTSLIQGASVP 796

  Fly   762 IFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGL 826
            |||.:....|.:....|....|.    .:|...|:.....|.:.|...|.|.|:.:...:..|.|
pombe   797 IFAYVISKCLNLFMQIDPSIGVA----FWSSMVLVVAAGSGASYFFSHYIFSISAKIWCDHYRLL 857

  Fly   827 MFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWS 891
            ..:.:..|:.||||...|....|...|..:.:.::......|..:..:.:...:|||.|....|.
pombe   858 AVKVLFTQDQAWFDQIENYPLVLSKILVNNISDMRNMISSLIEEVFIAFTMAIIGIAWSFATGWR 922

  Fly   892 LGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYI 956
            |..|.:|.:|.:.:...|...:...........:.:.|.:..:.:.|:.|:........|.:|:.
pombe   923 LAAVLVAVSPILCLTSRMFSYIYVSTERMCQDVVISTTSILHKTIVNLDTIKGYSVLSFFRENHK 987

  Fly   957 GMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTA 1021
            ..|..:.|..||...:..|.:.:..||::|..|...|..:..:...   |..|.::.|.|.:.|.
pombe   988 NSLRKSWEAFKRRAFWTSLGFAINNSLLYFVRALLFYCSSIFISKE---FYTVEQMVQVLSLATF 1049

  Fly  1022 SI---ANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYP--T 1081
            ::   :..:...||:.....|...:......:|..:.:.|..:.|  ..|.:.||.|.|:||  .
pombe  1050 TLLMASTCIMSLPNVSASRIATSRVLKLSSLKPGNLHKSGYLKFP--LVGKIEFDGVSFAYPDSE 1112

  Fly  1082 RSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRN 1146
            |:.: .|..:.|::...:|:|:||.||.||||.::|:::.|..::  ..||...:.|:....|..
pombe  1113 RNHL-ALNNVSLSIEAREKVAIVGISGSGKSTLVELLRKTYPSED--IYIDGYPLTNIDTNWLLK 1174

  Fly  1147 QLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQL 1211
            ::.||.|:|.|...||.|::.||.: |::  ..::.|..|:.:.|.|.|||.|.||.:.|.....
pombe  1175 KVAIVDQKPHLLGSTILESLLYGVD-RDI--NSVMDALDKTYMTEVIQNLPNGLDTPLLEFSKNF 1236

  Fly  1212 SGGQKQRIAIARALIRNPKIMLLDEATSALDAES----EKVVQDALDAASEGRTTISIAHRLSTV 1272
            ||||.||:|.||||:|||::::|||.|||||::|    ||.:|:.      ..|.:.|.|:.|.:
pombe  1237 SGGQIQRLAFARALLRNPRLLILDECTSALDSKSSLLLEKTIQNL------SCTVLIITHQPSLM 1295

  Fly  1273 VHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKL 1308
            ..:|.|.|.::|:|.|:|...:|: ||..::  :||
pombe  1296 KLADRIIVMDSGIVKESGSFDELM-NRHTHF--WKL 1328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 346/1326 (26%)
ABC_membrane 92..382 CDD:279056 66/308 (21%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 91/244 (37%)
ABC_membrane 750..1020 CDD:279056 57/269 (21%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 89/245 (36%)
mam1NP_001018819.2 MdlB 89..655 CDD:224055 168/615 (27%)
ABC_membrane 108..372 CDD:294371 62/302 (21%)
ABCC_MRP_Like 434..645 CDD:213195 84/213 (39%)
MdlB 767..1328 CDD:224055 156/585 (27%)
ABC_membrane 785..1049 CDD:294371 57/270 (21%)
P-loop_NTPase 1099..1332 CDD:304359 89/245 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24221
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
TreeFam 1 0.960 - -
54.960

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