Protein Alignment Mdr50 and pmd1

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001342744.1
• Gene: pmd1 / 2538709
• PomBaseID: SPCC663.03
• Length: 1362
• Species: Schizosaccharomyces pombe
• Alignment Length: 1399
• Identity: 505/1399 - (36%)
• Similarity: 749/1399 - (53%)
• Gaps: 149/1399 - (10%)

  Fly     4 KNGDVVKDDVNSRSQYKTNIVLGAKLEDSDRDRKSFEPNKSKKKSKHDESDASD--EEDGSQYHE 66
            |:...|||:.:|         |...::....:.|:|...||:.::  .||...|  ::...||..
pombe     7 KSTSTVKDNEHS---------LDLSIKSIPSNEKNFSTEKSENEA--SESHVVDVVKDPFEQYTP 60

  Fly    67 DVKQVSYFQ-------------LFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMID 118
            :.:::.|.|             :..||.|.|..|.:.|.::.:..||..|..||:.|.||....|
pombe    61 EEQEILYKQINDTPAKLSGYPRILSYADKWDIMLQLAGTITGIGAGLGMPLMSLVSGQLAQAFTD 125

  Fly   119 LGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKF 183
            |.    |||.       ::.....|..|.|...||.|.:..|||:....|..|.......||..:
pombe   126 LA----SGKG-------ASSFQHTVDHFCLYFIYIAIGVFGCSYIYTVTFIIAGERIARRIRQDY 179

  Fly   184 FRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSL 248
            ..:||.|::.::|...:||:.:|:..|.:.::|||.|||.:....:..||...|:||::.|:.:|
pombe   180 LHAILSQNIGYFDRLGAGEITTRITTDTNFIQDGLGEKVGLVFFAIATFVSGFVIAFIRHWKFTL 244

  Fly   249 VCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERV 313
            :..:..|.....:||.....::..|.::.:.|.::...|...|.||...||..:......|.:.:
pombe   245 ILSSMFPAICGGIGLGVPFITKNTKGQIAVVAESSTFVEEVFSNIRNAFAFGTQDILAKLYNKYL 309

  Fly   314 VAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVM 378
            :.|:...|.:.:..|:..|.::|..|..|.||||.|..|:..|       :.|...:|..||:|:
pombe   310 ITAQRFGINKAIAMGLMVGWMFFVAYGVYGLAFWEGGRLLHAG-------DLDVSKLIGCFFAVL 367

  Fly   379 MGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTR 443
            :.|.::...:|.:::|.....|..|:|..|:::..||.....|..:.:....||.|.:.|.||||
pombe   368 IASYSLANISPKMQSFVSCASAAKKIFDTIDRVSPINAFTPTGDVVKDIKGEIELKNIRFVYPTR 432

  Fly   444 PEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSR 508
            |||.:|:..:|....|:..||||.||.||||.|.||:|||||..|.:..:|.:|:.|::..||::
pombe   433 PEVLVLDNFSLVCPSGKITALVGASGSGKSTIIGLVERFYDPIGGQVFLDGKDLRTLNVASLRNQ 497

  Fly   509 IGVVGQEPILFATSIYENIRYGREDA-----TREEIEA----AAAAANAAIFIKKLPKGYDTLVG 564
            |.:|.|||:||||:::|||.||..|.     ::||:|.    ||..|||..||..||:.:.|.||
pombe   498 ISLVQQEPVLFATTVFENITYGLPDTIKGTLSKEELERRVYDAAKLANAYDFIMTLPEQFSTNVG 562

  Fly   565 ERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLS 629
            :||..:|||||||||||||:|.||:||||||||||||:.||..||.||:..|..||||::|||||
pombe   563 QRGFLMSGGQKQRIAIARAVISDPKILLLDEATSALDSKSEVLVQKALDNASRSRTTIVIAHRLS 627

  Fly   630 TVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQL---GEDDGSVL------SPTGDIYK 685
            |:|.||.|||:|.|::||.|:|.||::|...|..||..|.   ||.|..::      :|......
pombe   628 TIRNADNIVVVNAGKIVEQGSHNELLDLNGAYARLVEAQKLSGGEKDQEMVEEELEDAPREIPIT 692

  Fly   686 NFDIKDEDEE----EIKVLSEDEDEDVM----------VTDEK---------------------- 714
            :|...|||.:    |..::|.:.|.|.:          |.::|
pombe   693 SFGDDDEDNDMASLEAPMMSHNTDTDTLNNKLNEKDNVVFEDKTLQHVASEIVPNLPPADVGELN 757

  Fly   715 -NKKKKKKKVKDPNE-------------VKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAV 765
             ..||.||..|:.:|             |:.|:|:        :.:.:|.::|:|.|.|.|:.|.
pombe   758 EEPKKSKKSKKNNHEINSLTALWFIHSFVRTMIEI--------ICLLIGILASMICGAAYPVQAA 814

  Fly   766 LFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEA 830
            :|...|.|.:...:..::.: .|.:::|:||..||...|..:..:....|.|.:.:|:|..:|..
pombe   815 VFARFLNIFTDLSSTDFLHK-VNVFAVYWLILAIVQFFAYAISNFAMTYAMEAVLQRIRYHLFRT 878

  Fly   831 MLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLV 895
            :|||:|.:||...|..|::...||....:::|.:|..:||..|.::.:.....||:...|.||||
pombe   879 LLRQDVEFFDRSENTVGAITTSLSTKIQSLEGLSGPTLGTFFQILTNIISVTILSLATGWKLGLV 943

  Fly   896 ALAFTPFILIA-FYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGML 959
            .|:.:|.|:.| :|..|.|...:...||...|:.. .|.|..|.|||||||.|||.....|...|
pombe   944 TLSTSPVIITAGYYRVRALDQVQEKLSAAYKESAA-FACESTSAIRTVASLNREENVFAEYCDSL 1007

  Fly   960 IPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRG----ILFGDVFKVSQALIMGT 1020
            |.....|...:...||.:..|:.:.|...|...:||: .::.:|    :.|...|   .|::.|.
pombe  1008 IKPGRESAIASLKSGLFFSAAQGVTFLINALTFWYGS-TLMRKGEYNIVQFYTCF---IAIVFGI 1068

  Fly  1021 ASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEG---------YVRFDKVK 1076
            ........::.::.|..:||..|......:|.|        |.|.:||         .:.|.:|:
pombe  1069 QQAGQFFGYSADVTKAKAAAGEIKYLSESKPKI--------DTWSTEGKKVESLQSAAIEFRQVE 1125

  Fly  1077 FSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSM 1141
            ||||||..|:||:||.|.|..||.:|.||.|||||||.|.||:||||.|.||.|:|..:||:.::
pombe  1126 FSYPTRRHIKVLRGLNLTVKPGQFVAFVGSSGCGKSTTIGLIERFYDCDNGAVLVDGVNVRDYNI 1190

  Fly  1142 TNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGE 1206
            .:.|.|:.:|||||.|:..|:||||..| .:::|:::|:|.||||:||||||..||.||:|..|:
pombe  1191 NDYRKQIALVSQEPTLYQGTVRENIVLG-ASKDVSEEEMIEACKKANIHEFILGLPNGYNTLCGQ 1254

  Fly  1207 KGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLST 1271
            ||:.|||||||||||||||||||||:||||||||||:.||||||:||:|||:||||::||||||:
pombe  1255 KGSSLSGGQKQRIAIARALIRNPKILLLDEATSALDSHSEKVVQEALNAASQGRTTVAIAHRLSS 1319

  Fly  1272 VVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTL 1305
            :..:|.||||:.|::.|||.|.:|:..||.||.|
pombe  1320 IQDADCIFVFDGGVIAEAGTHAELVKQRGRYYEL 1353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	490/1332 (37%)
pmd1	NP_001342744.1	MdlB	73..666	CDD:440747	227/610 (37%)
		PTZ00265	139..1354	CDD:240339	469/1245 (38%)