DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and pmd1

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_001342744.1 Gene:pmd1 / 2538709 PomBaseID:SPCC663.03 Length:1362 Species:Schizosaccharomyces pombe


Alignment Length:1399 Identity:505/1399 - (36%)
Similarity:749/1399 - (53%) Gaps:149/1399 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 KNGDVVKDDVNSRSQYKTNIVLGAKLEDSDRDRKSFEPNKSKKKSKHDESDASD--EEDGSQYHE 66
            |:...|||:.:|         |...::....:.|:|...||:.::  .||...|  ::...||..
pombe     7 KSTSTVKDNEHS---------LDLSIKSIPSNEKNFSTEKSENEA--SESHVVDVVKDPFEQYTP 60

  Fly    67 DVKQVSYFQ-------------LFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMID 118
            :.:::.|.|             :..||.|.|..|.:.|.::.:..||..|..||:.|.||....|
pombe    61 EEQEILYKQINDTPAKLSGYPRILSYADKWDIMLQLAGTITGIGAGLGMPLMSLVSGQLAQAFTD 125

  Fly   119 LGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKF 183
            |.    |||.       ::.....|..|.|...||.|.:..|||:....|..|.......||..:
pombe   126 LA----SGKG-------ASSFQHTVDHFCLYFIYIAIGVFGCSYIYTVTFIIAGERIARRIRQDY 179

  Fly   184 FRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSL 248
            ..:||.|::.::|...:||:.:|:..|.:.::|||.|||.:....:..||...|:||::.|:.:|
pombe   180 LHAILSQNIGYFDRLGAGEITTRITTDTNFIQDGLGEKVGLVFFAIATFVSGFVIAFIRHWKFTL 244

  Fly   249 VCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERV 313
            :..:..|.....:||.....::..|.::.:.|.::...|...|.||...||..:......|.:.:
pombe   245 ILSSMFPAICGGIGLGVPFITKNTKGQIAVVAESSTFVEEVFSNIRNAFAFGTQDILAKLYNKYL 309

  Fly   314 VAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVM 378
            :.|:...|.:.:..|:..|.::|..|..|.||||.|..|:..|       :.|...:|..||:|:
pombe   310 ITAQRFGINKAIAMGLMVGWMFFVAYGVYGLAFWEGGRLLHAG-------DLDVSKLIGCFFAVL 367

  Fly   379 MGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTR 443
            :.|.::...:|.:::|.....|..|:|..|:::..||.....|..:.:....||.|.:.|.||||
pombe   368 IASYSLANISPKMQSFVSCASAAKKIFDTIDRVSPINAFTPTGDVVKDIKGEIELKNIRFVYPTR 432

  Fly   444 PEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSR 508
            |||.:|:..:|....|:..||||.||.||||.|.||:|||||..|.:..:|.:|:.|::..||::
pombe   433 PEVLVLDNFSLVCPSGKITALVGASGSGKSTIIGLVERFYDPIGGQVFLDGKDLRTLNVASLRNQ 497

  Fly   509 IGVVGQEPILFATSIYENIRYGREDA-----TREEIEA----AAAAANAAIFIKKLPKGYDTLVG 564
            |.:|.|||:||||:::|||.||..|.     ::||:|.    ||..|||..||..||:.:.|.||
pombe   498 ISLVQQEPVLFATTVFENITYGLPDTIKGTLSKEELERRVYDAAKLANAYDFIMTLPEQFSTNVG 562

  Fly   565 ERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLS 629
            :||..:|||||||||||||:|.||:||||||||||||:.||..||.||:..|..||||::|||||
pombe   563 QRGFLMSGGQKQRIAIARAVISDPKILLLDEATSALDSKSEVLVQKALDNASRSRTTIVIAHRLS 627

  Fly   630 TVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQL---GEDDGSVL------SPTGDIYK 685
            |:|.||.|||:|.|::||.|:|.||::|...|..||..|.   ||.|..::      :|......
pombe   628 TIRNADNIVVVNAGKIVEQGSHNELLDLNGAYARLVEAQKLSGGEKDQEMVEEELEDAPREIPIT 692

  Fly   686 NFDIKDEDEE----EIKVLSEDEDEDVM----------VTDEK---------------------- 714
            :|...|||.:    |..::|.:.|.|.:          |.::|                      
pombe   693 SFGDDDEDNDMASLEAPMMSHNTDTDTLNNKLNEKDNVVFEDKTLQHVASEIVPNLPPADVGELN 757

  Fly   715 -NKKKKKKKVKDPNE-------------VKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAV 765
             ..||.||..|:.:|             |:.|:|:        :.:.:|.::|:|.|.|.|:.|.
pombe   758 EEPKKSKKSKKNNHEINSLTALWFIHSFVRTMIEI--------ICLLIGILASMICGAAYPVQAA 814

  Fly   766 LFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEA 830
            :|...|.|.:...:..::.: .|.:::|:||..||...|..:..:....|.|.:.:|:|..:|..
pombe   815 VFARFLNIFTDLSSTDFLHK-VNVFAVYWLILAIVQFFAYAISNFAMTYAMEAVLQRIRYHLFRT 878

  Fly   831 MLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLV 895
            :|||:|.:||...|..|::...||....:::|.:|..:||..|.::.:.....||:...|.||||
pombe   879 LLRQDVEFFDRSENTVGAITTSLSTKIQSLEGLSGPTLGTFFQILTNIISVTILSLATGWKLGLV 943

  Fly   896 ALAFTPFILIA-FYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGML 959
            .|:.:|.|:.| :|..|.|...:...||...|:.. .|.|..|.|||||||.|||.....|...|
pombe   944 TLSTSPVIITAGYYRVRALDQVQEKLSAAYKESAA-FACESTSAIRTVASLNREENVFAEYCDSL 1007

  Fly   960 IPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRG----ILFGDVFKVSQALIMGT 1020
            |.....|...:...||.:..|:.:.|...|...:||: .::.:|    :.|...|   .|::.|.
pombe  1008 IKPGRESAIASLKSGLFFSAAQGVTFLINALTFWYGS-TLMRKGEYNIVQFYTCF---IAIVFGI 1068

  Fly  1021 ASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEG---------YVRFDKVK 1076
            ........::.::.|..:||..|......:|.|        |.|.:||         .:.|.:|:
pombe  1069 QQAGQFFGYSADVTKAKAAAGEIKYLSESKPKI--------DTWSTEGKKVESLQSAAIEFRQVE 1125

  Fly  1077 FSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSM 1141
            ||||||..|:||:||.|.|..||.:|.||.|||||||.|.||:||||.|.||.|:|..:||:.::
pombe  1126 FSYPTRRHIKVLRGLNLTVKPGQFVAFVGSSGCGKSTTIGLIERFYDCDNGAVLVDGVNVRDYNI 1190

  Fly  1142 TNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGE 1206
            .:.|.|:.:|||||.|:..|:||||..| .:::|:::|:|.||||:||||||..||.||:|..|:
pombe  1191 NDYRKQIALVSQEPTLYQGTVRENIVLG-ASKDVSEEEMIEACKKANIHEFILGLPNGYNTLCGQ 1254

  Fly  1207 KGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLST 1271
            ||:.|||||||||||||||||||||:||||||||||:.||||||:||:|||:||||::||||||:
pombe  1255 KGSSLSGGQKQRIAIARALIRNPKILLLDEATSALDSHSEKVVQEALNAASQGRTTVAIAHRLSS 1319

  Fly  1272 VVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTL 1305
            :..:|.||||:.|::.|||.|.:|:..||.||.|
pombe  1320 IQDADCIFVFDGGVIAEAGTHAELVKQRGRYYEL 1353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 490/1332 (37%)
ABC_membrane 92..382 CDD:279056 78/289 (27%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 133/245 (54%)
ABC_membrane 750..1020 CDD:279056 81/274 (30%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 144/236 (61%)
pmd1NP_001342744.1 AAA 139..1354 CDD:333001 469/1245 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 188 1.000 Domainoid score I741
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55496
Inparanoid 1 1.050 767 1.000 Inparanoid score I79
OMA 1 1.010 - - QHG63700
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - otm46968
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
TreeFam 1 0.960 - -
1312.760

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