DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and Abcb4

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_036822.1 Gene:Abcb4 / 24891 RGDID:620248 Length:1278 Species:Rattus norvegicus


Alignment Length:1329 Identity:562/1329 - (42%)
Similarity:805/1329 - (60%) Gaps:109/1329 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 AKLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIG 91
            |:..|.|.:..|.. |:|::|.|                 .|..:....||||:..:|:...::|
  Rat    11 ARRLDGDFELGSIS-NQSREKKK-----------------KVNLIGPLTLFRYSDWQDKLFMLLG 57

  Fly    92 LLSAVATGLTTPANSLIFGNLANDMIDLGG-----------LLESGKSYRADDAISTLLLDKVRQ 145
            ...|:|.|...|...::||.:.:..:|..|           :|..|:          :|.:::.:
  Rat    58 TAMAIAHGSGLPLMMIVFGEMTDKFVDNAGNFSLPVNFSLSMLNPGR----------ILEEEMTR 112

  Fly   146 FSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNED 210
            ::...:.:|..:|:.:|:.::.:..||..||..||.|||.:||.|:|.|:|...:.|:.:|:.:|
  Rat   113 YAYYYSGLGGGVLLAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEMGWFDIKGTTELNTRLTDD 177

  Fly   211 LSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKE 275
            :||:.:|:.:||.||...:..|....::.|::||:|:||.:....:..::..:.|...|..:.||
  Rat   178 ISKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKE 242

  Fly   276 VTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYA 340
            :..||.|..|||.||..||||.||.|:.||:..|::.:..||.:.||:.:.:.|..|:.:..|||
  Rat   243 LAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYA 307

  Fly   341 SYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVF 405
            |||||||||..|||.       :.|..|..:|||||:::|:.::|.|||.|:||..|:||...:|
  Rat   308 SYALAFWYGSTLVIS-------KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIF 365

  Fly   406 HIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGC 470
            .||:..|:|:.....|.|.:.....:||.:|.|.||:|..:.||..||||:..||||||||.|||
  Rat   366 DIIDNNPKIDSFSERGHKPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGC 430

  Fly   471 GKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDAT 535
            ||||.:||:||.|||..|.:..:|.::::.::..||..||||.|||:||:|:|.|||||||.:.|
  Rat   431 GKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVT 495

  Fly   536 REEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSAL 600
            .:||:.|...|||..||.|||:.:|||||:|||||||||||||||||||:|:|:|||||||||||
  Rat   496 MDEIKKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 560

  Fly   601 DTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLV 665
            ||.|||:|||||:|...|||||::||||||||.||.|.....|.:||.|:|.||::.:..||.||
  Rat   561 DTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLV 625

  Fly   666 TTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEK---------------- 714
            ..|   ..||                      ::||  |:.:|.::|||                
  Rat   626 NMQ---TSGS----------------------QILS--EEFEVELSDEKAAGGVAPNGWKARIFR 663

  Fly   715 NKKKKKKKVK---------DPNE----VKPM--LEVMKMNKPEWLQIAVGCISSVIMGCAMPIFA 764
            |..||..|..         :.||    |.|:  |:|:::||.||....||.:.::..|...|.|:
  Rat   664 NSTKKSLKSSRAHQNRLDVETNELDANVPPVSFLKVLRLNKTEWPYFVVGTLCAIANGALQPAFS 728

  Fly   765 VLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFE 829
            ::...::.|....| |...::..|.:||.||..|:......|||.:.||.|||.||.|||.:.|:
  Rat   729 IILSEMIAIFGPGD-DTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFK 792

  Fly   830 AMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGL 894
            |||||:::||||..|.||:|..||:.|||.||||||.|:..|.|:.:.|..||.:|..|.|.|.|
  Rat   793 AMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTL 857

  Fly   895 VALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGML 959
            :.|:..|||.:|..::..::|.......|.||...|:|.|.:.|||||.||.:|..|...|:..|
  Rat   858 LLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKL 922

  Fly   960 IPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIA 1024
            ......|.|..|..|:.:.::::.|:|:||.|..:|::.:::..:.|.||..|..|:::|..::.
  Rat   923 HGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALG 987

  Fly  1025 NALAFAPNMQKGVSAAKTIFTFLRRQPSI--VDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQV 1087
            :|.:|||:..|...:|..:|:...|||.|  ..|.|:..|.:  ||.|.|::|.|:||||:.:.|
  Rat   988 HASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPDKF--EGSVTFNEVVFNYPTRANVPV 1050

  Fly  1088 LKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVS 1152
            |:||.|.|.|||.:||||.|||||||.:||::||||...|..|:|..:.:.:::..||.||||||
  Rat  1051 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVS 1115

  Fly  1153 QEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQ 1217
            |||||||.:|.:||:||||:|.|:..||:.|.|::|||.||..||..|:||:|:||.||||||||
  Rat  1116 QEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQ 1180

  Fly  1218 RIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFE 1282
            ||||||||||.|:::||||||||||.|||||||:|||.|.||||.|.|||||||:.::|:|.|.:
  Rat  1181 RIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVID 1245

  Fly  1283 NGLVCEAGDHKQLLANRGLYYTLYKLQSG 1311
            ||.|.|.|.|:||||.:|:|:::..:|:|
  Rat  1246 NGKVKEHGTHQQLLAQKGIYFSMVNIQAG 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 551/1282 (43%)
ABC_membrane 92..382 CDD:279056 97/300 (32%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 144/236 (61%)
ABC_membrane 750..1020 CDD:279056 99/269 (37%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 145/238 (61%)
Abcb4NP_036822.1 PTZ00265 29..1271 CDD:240339 554/1305 (42%)
ABC_membrane 58..342 CDD:279056 97/300 (32%)
ABC_MTABC3_MDL1_MDL2 392..628 CDD:213216 144/235 (61%)
Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385 622..646 10/50 (20%)
ABC_membrane 714..984 CDD:279056 100/270 (37%)
ABC_MTABC3_MDL1_MDL2 1033..1272 CDD:213216 145/238 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 196 1.000 Domainoid score I3030
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1004 1.000 Inparanoid score I276
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - otm44372
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.780

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