Protein Alignment Mdr50 and Abcc1

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_071617.2
• Gene: Abcc1 / 24565
• RGDID: 3112
• Length: 1532
• Species: Rattus norvegicus
• Alignment Length: 1205
• Identity: 284/1205 - (23%)
• Similarity: 520/1205 - (43%)
• Gaps: 197/1205 - (16%)

  Fly   201 GEVASRMNEDLSKMEDGLAE----------KVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLP 255
            ||:.:.|:.|..:..| ||.          :|.:.:::|...:|..|||.|      .|.:..:|
  Rat   422 GEIVNLMSVDAQRFMD-LATYINMIWSAPLQVTLALYFLWLNLGPSVLAGV------AVMILMVP 479

  Fly   256 LTFI-AMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVV----- 314
            ...: ||.......:.:..|:     ....:....|:||:.:|.:..|    .|::::|:
  Rat   480 FNAVMAMKTKTYQVAHMKSKD-----NRIKLMNEILNGIKVLKLYAWE----LAFQDKVMNIRQE 535

  Fly   315 AAKILNIKRNMFSGIGFGLLWF---FIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFS 376
            ..|:|. |....:.:| ...|.   |:.|....|.:..|       .|....:.....:....|:
  Rat   536 ELKVLK-KSAYLAAVG-TFTWVCTPFLVALSTFAVFVTV-------DEKNILDAKKAFVSLALFN 591

  Fly   377 VMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINP--------IDGEGKKLNEPLTTIEF 433
            ::...:||   .|.:.:..:......|...|.....|:.|        .||.|      :.:|..
  Rat   592 ILRFPLNI---LPMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGG------MNSITV 647

  Fly   434 KEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLK 498
            |...|.: .|.|...||.:...|..|..||:||..|||||:.:..:....|...|::...|:
  Rat   648 KNATFTW-ARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGS--- 708

  Fly   499 DLDINWLRSRIGVVGQEPILFATSIYENIRYGR---EDATREEIEAAAAAANAAIFIKKLPKGYD 560
                      :..|.|:..:...|:.|||.:||   |...:..:||.|...:..|    ||.|..
  Rat   709 ----------VAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEI----LPSGDL 759

  Fly   561 TLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSA------GR 619
            |.:||:|..||||||||:::|||:..:.:|.|||:..||:|......:   .|||..      .:
  Rat   760 TEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHI---FEKVVGPMGLLKNK 821

  Fly   620 TTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIY 684
            |.|:|.|.:|.:.:.|.|:|::.|::.|.|::|||::....:...|.|....:.
  Rat   822 TRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQ----------- 875

  Fly   685 KNFDIKDEDEEEIKVL-----SEDEDEDVMVTDEKNK------------------------KKKK 720
               |:..||:.:..|.     |:..:..::|||...|                        :.:|
  Rat   876 ---DLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQK 937

  Fly   721 KKVKDPNEVKPMLEVMKMNKPEWLQI----------AVG-CISSVIMGCAMPIFAVLFGSILQI- 773
            ..||:..     .::|:.:|.:..|:          |:| |||      .:.||..|...:..:
  Rat   938 SGVKEET-----WKLMEADKAQTGQVKLSVYWNYMKAIGLCIS------FLSIFLFLCNHVSALA 991

  Fly   774 ----LSVKDNDQ----YVRENSN-QYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFE 829
                ||:..:|:    ..:||.| :.|:|..: ||:.|:|.|.......|.|...:.||...:.:
  Rat   992 SNYWLSLWTDDRPAVNGTQENRNFRLSVYGAL-GILQGVAVFGYSMAVSIGGIFASRRLHLDLLQ 1055

  Fly   830 AMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGL 894
            .:||..:::|:  ...:|:|..|.|.:...|.....|.|...:.|:.::...:.:.:.   :..:
  Rat  1056 NVLRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILL---ATPI 1115

  Fly   895 VALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAV-----EVVSNIRTVASLGREEMF-HQ 953
            .|:...|..|:.|::||..:|...  ..|.:|:.::..|     |.:..:..:.:...:|.| .|
  Rat  1116 AAVIIPPLGLVYFFVQRFYVASSR--QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQ 1178

  Fly   954 NYIGMLIPAVEISKRNTHFRGLVYG--LARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQAL 1016
            :.:.:      ...:..::..:|..  ||..|........::...:.||.|..|...:..:|.:.
  Rat  1179 SDLKV------DENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSY 1237

  Fly  1017 IMGTASIANALA-FAPNMQKGVSAAKTI--FTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFS 1078
            .:...:..|.|. .:..|:..:.|.:.:  ::...::.|...:.......|...|.|.|......
  Rat  1238 SLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLR 1302

  Fly  1079 YPTRSEIQ-VLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMT 1142
            |  |.::. |||.:.:.:..|:|:.:||.:|.|||:....:.|..:..||..:||..::..:.:.
  Rat  1303 Y--REDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH 1365

  Fly  1143 NLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEK 1207
            |||.::.|:.|:|:||..::|.|:   |.....:|:|:..|.:.:::..|::.||...:....|.
  Rat  1366 NLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEG 1427

  Fly  1208 GAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTV 1272
            |..||.||:|.:.:||||:|..||::|||||:|:|.|::.::|..:....|..|.::|||||:|:
  Rat  1428 GENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTI 1492

  Fly  1273 VHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYK 1307
            :....:.|.:.|.:.|.|...:||..||::|::.|
  Rat  1493 MDYTRVIVLDKGEIRECGAPSELLQQRGVFYSMAK 1527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	284/1205 (24%)
		ABC_membrane	92..382	CDD:279056	37/199 (19%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	77/245 (31%)
		ABC_membrane	750..1020	CDD:279056	57/287 (20%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	78/239 (33%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	284/1205 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000