Protein Alignment Mdr50 and ABCB10

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_036221.2
• Gene: ABCB10 / 23456
• HGNCID: 41
• Length: 738
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 198/580 - (34%)
• Similarity: 318/580 - (54%)
• Gaps: 29/580 - (5%)

  Fly   744 LQIAVGCIS-SVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFL 807
            |..|||.:: |.::..:.|.|   .|.|:.::.......| .:|..:..|......:....|..:
Human   171 LAAAVGFLTMSSVISMSAPFF---LGKIIDVIYTNPTVDY-SDNLTRLCLGLSAVFLCGAAANAI 231

  Fly   808 QIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIV 872
            ::|....:|:|:..|||..:|.::||||||:||  ...||.|..|||.|.|.:..:..:.:...:
Human   232 RVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGL 294

  Fly   873 QSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVS 937
            ::.:..::||::..:...:|....|:..|.:.|...:....:.|....:..::...|:||.|.:.
Human   295 RAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIG 359

  Fly   938 NIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVY---GLARSLMFFAYAACMYYGTWCV 999
            |:|||.:.|:|....:.|...:...::::::....|...:   ||:.:|:..   :.:|.|
Human   360 NVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVL---SVLYKG---- 417

  Fly  1000 IHRGILFGD----VFKVSQALIMG---TASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRP 1057
               |:|.|.    |.::|..|:..   ..||....:|...:.||:.|...::..|.|:|.:....
Human   418 ---GLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNE 479

  Fly  1058 GVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFY 1122
            ||..:....:|.:.|..|.|:||.|.|:.:.:...|::..|...|||||||.||||.:.|:.|.|
Human   480 GVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLY 544

  Fly  1123 DVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYG-DNARNVTDQEIISACKK 1186
            |...|...:|..|:|.::...||:::|.||||||||..:|.|||:|| |:..:||.:||....:.
Human   545 DPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEV 609

  Fly  1187 SNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQD 1251
            :|...||.|.|.|::|.:||||..|||||||||||||||::||||:||||||||||||:|.:||:
Human   610 ANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQE 674

  Fly  1252 ALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLAN-RGLYYTLYKLQS 1310
            |||...:|||.:.|||||||:.:::::.|.:.|.:.|.|.|::||:. .|:|..|...||
Human   675 ALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	196/576 (34%)
		ABC_membrane	92..382	CDD:279056
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216
		ABC_membrane	750..1020	CDD:279056	62/280 (22%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	118/240 (49%)
ABCB10	NP_036221.2	mitochondrial targeting sequence	1..105
		PWWP	1..>26	CDD:295359
		MdlB	163..734	CDD:224055	196/578 (34%)
		ABC_membrane	177..438	CDD:279056	62/276 (22%)
		ABC_MTABC3_MDL1_MDL2	493..733	CDD:213216	118/239 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810