Protein Alignment Mdr50 and Tap2

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_035660.3
• Gene: Tap2 / 21355
• MGIID: 98484
• Length: 702
• Species: Mus musculus
• Alignment Length: 538
• Identity: 177/538 - (32%)
• Similarity: 276/538 - (51%)
• Gaps: 41/538 - (7%)

  Fly   150 NTYIGIIMLVC-----SYLSITC----FNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVAS 205
            :.:...|..:|     |..|..|    |.:......|.||.:.|.|:|.||:.::...::||:.|
Mouse   186 DAFASAIFFMCLFSVGSSFSAGCRGGSFLFTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNS 250

  Fly   206 RMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSR 270
            |::.|.|.|...|.....:.:..||..||..........:|:.:.|..||||..|..:.......
Mouse   251 RLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQA 315

  Fly   271 LAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLW 335
            :.|:.....|.|..|...|:.|::||::|..|.:||:.|||.:...:.|..:|::...:...:..
Mouse   316 VLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVSHYKEALERCRQLWWRRDLEKDVYLVIRR 380

  Fly   336 FFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGA 400
            ........|....||..::.|      |....|.:..:.:...:|.....:...|.:..... ||
Mouse   381 VMALGMQVLILNCGVQQILAG------EVTRGGLLSFLLYQEEVGQYVRNLVYMYGDMLSNV-GA 438

  Fly   401 CAKVFHIIEQIPEINPIDG-------EGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHR 458
            ..|||..:::.|.: |..|       ||:        :||::|.|.||.|||..:|..|...:|.
Mouse   439 AEKVFSYLDRKPNL-PQPGILAPPWLEGR--------VEFQDVSFSYPRRPEKPVLQGLTFTLHP 494

  Fly   459 GQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSI 523
            |...|||||:|.||||...|:|..|.|..|.||.:|..|.:.|.::|..::.:|||||:||:.|:
Mouse   495 GTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSV 559

  Fly   524 YENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDP 588
            .:||.||..|....::.|||.||.|..||.::..|.:|.:||:|.||:.|||||:||||||:|:|
Mouse   560 KDNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNP 624

  Fly   589 EILLLDEATSALDTASEAKVQAALE--KVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTH 651
            .:|:|||||||||    |:.:.||:  :....||.:::||||.||:.||:::|:.:|.:||   |
Mouse   625 RVLILDEATSALD----AQCEQALQNWRSQGDRTMLVIAHRLHTVQNADQVLVLKQGRLVE---H 682

  Fly   652 QELMELKDHYFNLVTTQL 669
            .:|.:.:|.|.:||..:|
Mouse   683 DQLRDGQDVYAHLVQQRL 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	177/538 (33%)
		ABC_membrane	92..382	CDD:279056	57/240 (24%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	108/238 (45%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
Tap2	NP_035660.3	3a01208	1..696	CDD:273363	174/532 (33%)
		ABC_membrane	155..415	CDD:279056	56/234 (24%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	300..388		21/87 (24%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	413..432		2/18 (11%)
		P-loop_NTPase	456..679	CDD:304359	103/234 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12044
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24221
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100