Protein Alignment Mdr50 and haf-8

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_502776.1
• Gene: haf-8 / 190369
• WormBaseID: WBGene00001818
• Length: 633
• Species: Caenorhabditis elegans
• Alignment Length: 609
• Identity: 219/609 - (35%)
• Similarity: 326/609 - (53%)
• Gaps: 78/609 - (12%)

  Fly   126 GKSYR-------------ADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSI----------TC 167
            ||.:|             |.:.|...|..::...::|.....||...|..|::          .|
 Worm    51 GKQWRWFVPAYTLLILDCALNLIEPALYGQMMTNAIQMKSFDIIKRACLLLALIQFSEATCKSAC 115

  Fly   168 FNYAAHSQILT---IRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYL 229
            :.:..:::.||   ||.:.|||||||::.::|.|::|::.||:..|...:.:.|...:...|:.|
 Worm   116 YFFMQYAEKLTARNIRIQLFRSILHQEISFFDENKTGQLVSRITHDSESISNTLPVHIETLVNNL 180

  Fly   230 VAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIR 294
            ..|.||:.:.|...|||:|......|:|.:......:|..:|::||....|.:....|..||.||
 Worm   181 FMFFGSIPIMFCYSWQLTLTSFIEFPITLLMTRYYGLAVEKLSEKENDATAASNETVEEVLSAIR 245

  Fly   295 TVKAFEGEAKEVAAYKERV-----VAAKILNIKRNMFSGIGFGLLWFFIYASY-ALAFWYGVGLV 353
            ||::|..|..|...|.:..     ::.|.:.:      |..:...|..:..|. .:.:.||..|.
 Worm   246 TVRSFAAENFEQKRYTKNTEDWFKISTKTVTL------GTIYNYFWALMLRSQDVIRYLYGGYLA 304

  Fly   354 IKGYHEP------AYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIP 412
            :.|...|      .:.::...|.|..|.|:..|.|         :..|:::    ||.|:|.:.|
 Worm   305 LNGRMAPEALLTFIFYHWRLHTAINAFSSLFSGVM---------KTIGLSR----KVIHLINRKP 356

  Fly   413 EINPIDG------EGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCG 471
            :::...|      :||        |||:.|||.||||..|:::|.:||.|..|:|||||||||.|
 Worm   357 QLDYDFGTETPEIQGK--------IEFEVVEFAYPTRKTVNVINGINLSIESGKTVALVGPSGNG 413

  Fly   472 KSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATR 536
            |||.:.|:|:||.||:|.:|.:|..:::::.....|.|.:|.|||.||:.:|.|||.:|.|:.|.
 Worm   414 KSTLVSLIQQFYTPQSGRILTDGIPIQNINHQHYHSNIALVAQEPTLFSGTIRENILFGIENGTE 478

  Fly   537 EEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALD 601
            |.:..||..||...|:.|:..||||..||:|.|:||||||||||||||||:|.:|:|||||||||
 Worm   479 EAMLKAAEMANVHEFVSKMDDGYDTKCGEKGVQMSGGQKQRIAIARALIRNPRVLILDEATSALD 543

  Fly   602 TASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDH-YFNLV 665
            :.||..||.||.|.:..||.|::||||||||:|.:|.||..|.|.|.|.|.||||.:|. |:.||
 Worm   544 SESEGMVQEALNKCAKERTVIVIAHRLSTVRKAQKIAVIENGSVKEMGCHDELMENQDGLYYKLV 608

  Fly   666 TTQLGEDDGSVLSPTGDIYKNFDI 689
            :.||    ||::..  :|:..||:
 Worm   609 SKQL----GSIVDT--NIFNCFDM 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	219/609 (36%)
		ABC_membrane	92..382	CDD:279056	72/293 (25%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	130/237 (55%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
haf-8	NP_502776.1	MdlB	42..613	CDD:224055	214/592 (36%)
		ABC_membrane	63..318	CDD:279056	64/260 (25%)
		ABC_MTABC3_MDL1_MDL2	373..611	CDD:213216	130/237 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010