Protein Alignment Mdr50 and pgp-7

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001361833.1
• Gene: pgp-7 / 188697
• WormBaseID: WBGene00004001
• Length: 1152
• Species: Caenorhabditis elegans
• Alignment Length: 1172
• Identity: 365/1172 - (31%)
• Similarity: 590/1172 - (50%)
• Gaps: 110/1172 - (9%)

  Fly    76 LFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLL 140
            :|:..:..::.|::||:..::.|||..|..|...|..|..::.:            .:||:...:
 Worm    31 IFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLVTI------------TNAINNKTI 83

  Fly   141 DKVRQFSLQNTY----IGIIMLV-------CSYLSI-----TCFNYAAHSQILTIRSKFFRSILH 189
            |..   .|:..|    .|:..:|       |:|.:.     ....|...:....:|.::...:|.
 Worm    84 DPA---DLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLR 145

  Fly   190 QDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSL 254
            :|.:::|...:|.:::.:|::|.:..:...||:.:....|..||....|||...|:|:...:
 Worm   146 KDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGI--- 207

  Fly   255 PLTFIAMGLV------AVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERV 313
               |.::|:.      :....:...|:.|.||.|..:|...|...:||.:..|:..|:..|.|.:
 Worm   208 ---FFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYTEEL 269

  Fly   314 VAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVM 378
            .|.:...|.|.:...|..|..:||..:...:..:.|..::..|..|||       .::.:|..:|
 Worm   270 KAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMIYSGSLEPA-------VVVRIFHYMM 327

  Fly   379 MGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLN---EPLTTIEFKEVEFQY 440
            .|:..:..|.|:|.....|..:.|.:..::  |.|.|.|:.:....:   |....|.||.|:|.|
 Worm   328 FGAFCLSEALPHISRLAGAISSTAPIAEML--IKEDNVIEKDETDYDVEVEVNGNISFKNVKFSY 390

  Fly   441 PTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWL 505
            ||||:..:|..::..:..|:.:||||.||.||||.:||:..:|:..:||:..:|.:|.|::|..|
 Worm   391 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRL 455

  Fly   506 RSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQL 570
            |..||||.|||:||.|:|.||||:|..:.:..||..|...|||..|:...|||..|:|||||.||
 Worm   456 RRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 520

  Fly   571 SGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRAD 635
            ||||||||||||.|:|:|:||||||||||||..||..||.|||..|.|||||:|||||||:|.|.
 Worm   521 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNAS 585

  Fly   636 RIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGE--DDGSVLSPTGDIYKNFDIKDEDEEEIK 698
            :|:|:.|||:||.|.|.||:..:..|.:||..||.|  ||...|.|......:.::.......|:
 Worm   586 KIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQ 650

  Fly   699 VLSEDE----DEDV-MVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGC 758
            ..:.::    |:|: .:.||.:|:..||        ..:.|::|..:|::..:.:....|.|.|.
 Worm   651 RSTSNDAGVHDDDMERILDELSKEGAKK--------SNLREIVKQCRPDYCFLFIAVFGSAIQGV 707

  Fly   759 AMPIFAVLFGSILQILSVKDNDQYVREN----SNQYSLYFLIAGIVVGIATFLQIYFFGIAGERL 819
            :.||.|.|      |:...:....:.|:    |:.::|.|:...:...:..:.|.|:||...|:|
 Worm   708 SYPILAQL------IVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQL 766

  Fly   820 TERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIAL 884
            :.|||...|..||....|::||..:....|..||:.|::.|:.|...|:|.::.::..:::.|..
 Worm   767 STRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITT 831

  Fly   885 SMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGRE- 948
            :..|.|.:.|..|.|.|.:.:|.|.................||..:.|:|.:.|:|||.:|..|
 Worm   832 ASLYCWKMTLEVLIFFPLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLED 896

  Fly   949 ----------EMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRG 1003
                      :..|::|....|           .:|...||:.|...|.|:....:||:..:.:.
 Worm   897 KIMSLISEHLQKIHKSYFKRAI-----------IQGAANGLSLSCYLFVYSVSFKFGTYLALRKE 950

  Fly  1004 ILFGDVFKVSQALIMGTASIA-NALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHS- 1066
            :...|.:.:.:.|.| ||::| :|.|:.|:.:|.|.||..|| .|...|:.:  |..|.|...:
 Worm   951 VAPMDTYLILETLSM-TANMAGSAAAYLPDYKKAVHAAGLIF-HLFTYPATM--PFSSSDGKKNI 1011

  Fly  1067 -EGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATL 1130
             :|.:..:.|:|.|..|.:..:|.|:.|.|..|:.:||||||||||||.|.|::|||...:|...
 Worm  1012 EKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVK 1076

  Fly  1131 IDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIAN 1195
            ||..:|.::::.:||:.|.:|||||.||:.:||||:.|| ..|:|...|:..|.:.:|...|:..
 Worm  1077 IDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQ 1140

  Fly  1196 LP 1197
            .|
 Worm  1141 FP 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	365/1172 (31%)
pgp-7	NP_001361833.1	MdlB	40..622	CDD:440747	209/611 (34%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	82/326 (25%)
		TM helix 1	695..718	CDD:350022	8/28 (29%)
		TM helix 2	733..781	CDD:350022	15/47 (32%)
		TM helix 3	790..835	CDD:350022	9/44 (20%)
		TM helix 4	836..885	CDD:350022	11/48 (23%)
		TM helix 5	897..947	CDD:350022	11/60 (18%)
		TM helix 6	956..989	CDD:350022	12/33 (36%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1019..>1143	CDD:476819	53/125 (42%)