DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and Abcb1a

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_035206.2 Gene:Abcb1a / 18671 MGIID:97570 Length:1276 Species:Mus musculus


Alignment Length:1292 Identity:574/1292 - (44%)
Similarity:809/1292 - (62%) Gaps:27/1292 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 KLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGL 92
            :||:..:.|.....:|..||||.::.            |....||...:||||...||...::|.
Mouse     2 ELEEDLKGRADKNFSKMGKKSKKEKK------------EKKPAVSVLTMFRYAGWLDRLYMLVGT 54

  Fly    93 LSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADD--AISTLLLDKVRQFSLQNTYIGI 155
            |:|:..|:..|...||||::.:....:|.:.::..:....|  |:...|.:::..::...|.||.
Mouse    55 LAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGA 119

  Fly   156 IMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAE 220
            .:|:.:|:.::.:..||..||..||.|||.:|::|::.|:|.:..||:.:|:.:|:||:.:|:.:
Mouse   120 GVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGD 184

  Fly   221 KVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVV 285
            |:.||...:..|.|..::.|.:||:|:||.|...|:..::.|:.|...|....||:..||.|..|
Mouse   185 KIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAV 249

  Fly   286 AEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGV 350
            ||..|:.||||.||.|:.||:..|...:..||.|.||:.:.:.|..|..:..||||||||||||.
Mouse   250 AEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGT 314

  Fly   351 GLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEIN 415
            .|||.       :.|..|.::||||||::|:.::|.|:|.||||..|:||..:||.||:..|.|:
Mouse   315 SLVIS-------KEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSID 372

  Fly   416 PIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQ 480
            .....|.|.:.....:|||.:.|.||:|.||.||..||||:..||||||||.|||||||.:||:|
Mouse   373 SFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQ 437

  Fly   481 RFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAA 545
            |.|||..|.:..:|.:::.:::.:||..||||.|||:||||:|.|||||||||.|.:|||.|...
Mouse   438 RLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKE 502

  Fly   546 ANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQA 610
            |||..||.|||..:|||||||||||||||||||||||||:|:|:|||||||||||||.|||.|||
Mouse   503 ANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA 567

  Fly   611 ALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDD-- 673
            ||:|...|||||::||||||||.||.|...:.|.:||.|.|.|||..|..||.||.||...::  
Mouse   568 ALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIE 632

  Fly   674 -GSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKKKKVKDPNEVKP--MLEV 735
             |:....:.|...|.|:..:|.....:......:.:....::::|...|:..| .:|.|  ...:
Mouse   633 LGNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALD-EDVPPASFWRI 696

  Fly   736 MKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIV 800
            :|:|..||....||...::|.|...|.|:|:|..::.:.:.....:..|:|||.:||.|||.||:
Mouse   697 LKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGII 761

  Fly   801 VGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATG 865
            ..|..|||.:.||.|||.||:|||.::|::||||:|:||||..|.||:|..||:.|||.|:||||
Mouse   762 SFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATG 826

  Fly   866 QRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTK 930
            .|:..|.|:|:.|..||.:|:.|.|.|.|:.||..|.|.||..::..:::.:.:...|.:|...|
Mouse   827 SRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGK 891

  Fly   931 LAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYG 995
            :|.|.:.|.|||.||.||:.|...|...|......:.:..|..|:.:...:::|:|:||||..:|
Mouse   892 IATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFG 956

  Fly   996 TWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVS 1060
            .:.|..:.:.|.:|..|..|::.|..::....:|||:..|...:|..|...:.:.|.|.......
Mouse   957 AYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQG 1021

  Fly  1061 RDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVD 1125
            ..|...||.|:|..|.|:||||..|.||:||.|.|.|||.:||||.|||||||.:||::||||..
Mouse  1022 LKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPM 1086

  Fly  1126 EGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIH 1190
            .|:..:|..:::.:::..||.|||||||||||||.:|.|||:||||:|.|:.:||:.|.|::|||
Mouse  1087 AGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIH 1151

  Fly  1191 EFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDA 1255
            :||.:||..|:||:|:||.||||||||||||||||:|.|.|:||||||||||.|||||||:|||.
Mouse  1152 QFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDK 1216

  Fly  1256 ASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQSGA 1312
            |.||||.|.|||||||:.::|:|.|.:||.|.|.|.|:||||.:|:|:::..:|:||
Mouse  1217 AREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGA 1273

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 562/1245 (45%)
ABC_membrane 92..382 CDD:279056 103/291 (35%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 153/236 (65%)
ABC_membrane 750..1020 CDD:279056 103/269 (38%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 146/238 (61%)
Abcb1aNP_035206.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 8/23 (35%)
PTZ00265 47..1263 CDD:240339 554/1223 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..681 4/34 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 206 1.000 Domainoid score I2901
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55496
Inparanoid 1 1.050 1050 1.000 Inparanoid score I261
Isobase 1 0.950 - 0 Normalized mean entropy S1571
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - otm42316
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1514.760

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