DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and Abcb1b

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_035205.1 Gene:Abcb1b / 18669 MGIID:97568 Length:1276 Species:Mus musculus


Alignment Length:1308 Identity:561/1308 - (42%)
Similarity:813/1308 - (62%) Gaps:59/1308 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 KLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGL 92
            :.|::.:.|.....:|..||||.::.            |....|..|.:||||...|:...::|.
Mouse     2 EFEENLKGRADKNFSKMGKKSKKEKK------------EKKPAVGVFGMFRYADWLDKLCMILGT 54

  Fly    93 LSAVATGLTTPANSLIFGNLANDMIDLGGLL------ESGKSYRADDAISTLLL------DKVRQ 145
            |:|:..|...|...|:|||:.:........:      :||.:       |||::      :::..
Mouse    55 LAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQSGPN-------STLIISNSSLEEEMAI 112

  Fly   146 FSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNED 210
            ::...|.||..:|:.:|:.::.:..||..||..||.|||.:|::|::.|:|.:..||:.:|:.:|
Mouse   113 YAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDD 177

  Fly   211 LSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKE 275
            :||:.||:.:|:.||...:..|:...::.|:.||:|:||.|...||..::..|.|...:....||
Mouse   178 VSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKE 242

  Fly   276 VTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYA 340
            :..||.|..|||..|:.||||.||.|:.||:..|.:.:..||.:.||:.:.:.|..|:.:..:||
Mouse   243 LQAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYA 307

  Fly   341 SYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVF 405
            |||||||||..||:.       ..|..|.::|||||:::|:.:||..||.||||..|:||..::|
Mouse   308 SYALAFWYGTSLVLS-------NEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIF 365

  Fly   406 HIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGC 470
            .||:..|.|:....:|.|.:..:..:|||.|.|.||:|.||.||..||||:..||||||||.|||
Mouse   366 KIIDNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGC 430

  Fly   471 GKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDAT 535
            ||||.:||:||.|||..|.:..:|.:::.:::.:||..||||.|||:||||:|.|||||||||.|
Mouse   431 GKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVT 495

  Fly   536 REEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSAL 600
            .:|||.|...|||..||.|||..:|||||||||||||||||||||||||:|:|:|||||||||||
Mouse   496 MDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 560

  Fly   601 DTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLV 665
            ||.|||.|||||:|...|||||::||||||||.||.|...:.|.:||.|.|.|||..|..||.||
Mouse   561 DTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLV 625

  Fly   666 TTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMV-----------TDEKNKKKK 719
            .||   ..|:.:.|..:.|.:....|..|     |:.:|.:..::           .|::.:...
Mouse   626 MTQ---TRGNEIEPGNNAYGSQSDTDASE-----LTSEESKSPLIRRSIYRSVHRKQDQERRLSM 682

  Fly   720 KKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVR 784
            |:.|.:...:.....::.:|..||..:.||.:.:||.||..|:||::|..|:.:.|..|:.:..|
Mouse   683 KEAVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETKR 747

  Fly   785 ENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSL 849
            :|.|.:||:||:.|::..:..|.|.:.||.|||.||:|:|.::|::||||:::||||..|.||||
Mouse   748 QNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSL 812

  Fly   850 CARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLM 914
            ..||:.||::|:||.|.|:..:.|:::.|..|:.||:.|.|.|.|:.:...|.|::...::..|:
Mouse   813 TTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLL 877

  Fly   915 AKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGL 979
            :.:.:...|.:|...|:|.|.:.|.||:.||.||:.|...|...|......:.:..|..|:.:..
Mouse   878 SGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSF 942

  Fly   980 ARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIF 1044
            .:::|:|:||||..:|.:.|..:.:.|.:|..|..|::.|..:..|..:|||:..|...:|..|.
Mouse   943 TQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHII 1007

  Fly  1045 TFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGC 1109
            ..:.:.|.|.........|...||.|:|:.|:|:||||..|.||:||.|.|.|||.:||||.|||
Mouse  1008 RIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGC 1072

  Fly  1110 GKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARN 1174
            ||||.:||::||||...|:..:|..:::.:::..||..||||||||||||.:|.|||:||||:|.
Mouse  1073 GKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRA 1137

  Fly  1175 VTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATS 1239
            |:.:||:.|.|::|||:||.:||..|:||:|:||.||||||||||||||||:|.|.|:|||||||
Mouse  1138 VSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATS 1202

  Fly  1240 ALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYT 1304
            |||.|||||||:|||.|.||||.|.|||||||:.::|:|.|.|||.|.|.|.|:||||.:|:|::
Mouse  1203 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFS 1267

  Fly  1305 LYKLQSGA 1312
            :  :|:||
Mouse  1268 M--VQAGA 1273

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 550/1261 (44%)
ABC_membrane 92..382 CDD:279056 100/301 (33%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 154/236 (65%)
ABC_membrane 750..1020 CDD:279056 94/269 (35%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 146/238 (61%)
Abcb1bNP_035205.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 7/23 (30%)
PTZ00265 55..1270 CDD:240339 542/1238 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..659 6/30 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 206 1.000 Domainoid score I2901
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1050 1.000 Inparanoid score I261
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - otm42316
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.810

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