DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and pgp-11

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_001364583.1	Gene:	pgp-11 / 183971	WormBaseID:	WBGene00004005	Length:	1241	Species:	Caenorhabditis elegans

Alignment Length:	1313	Identity:	417/1313 - (31%)
Similarity:	640/1313 - (48%)	Gaps:	126/1313 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFG 110
            ||.....|...||...|.....::| |...:..:|.|.|....:..|:.|:..|...|. .|:.|
Worm     5 KKLCRPVSAFGDESKVSDVTPSIRQ-SLNLMINFAKKSDLIFIITALICALLGGTIQPV-VLLIG 67

  Fly   111 NLANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYI------GIIMLVCSYLSITCFN 169
            ....|:     .|.:|.:...|:.:.::|           |.|      |:|:||.:.:...|..
Worm    68 GWITDL-----YLTNGNTAGNDEFLYSVL-----------TLIYAGLGFGVIILVLALIQGVCIQ 116

  Fly   170 YAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVG 234
            ......:.:||.:|..::|.||..|.|.:.||.:..::||::..:.|||..|..|.|.....|..
Worm   117 RGTSRILDSIRKEFLGAVLRQDANWLDKHSSGSITCQLNENIEVISDGLGNKCCMLVRGFAMFTS 181

  Fly   235 SLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAF 299
            |::......|||:.:..|..|::...:.|:........::.:::.|.:..:.|.::..:|||::.
Worm   182 SIIACAFINWQLTFITFTMGPVSAFVLHLLTKVNEVSNEELMSLSAQSHAIIEESILNVRTVQSC 246

  Fly   300 EGE---AKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPA 361
            .|:   ..::....|::  .|..| |...::|...||..|.||....::.::|..|
Worm   247 NGQNFMITKLNQVNEKI--KKFYN-KSTFWAGFFDGLALFVIYFITGISLFFGCRL--------- 299

  Fly   362 YENYD---AGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKK 423
            |.|.:   ||.:|.:..::.:....:|:..|::.:...|..:...::..||..|:....:|| .|
Worm   300 YFNQEIGKAGDVILIVNTICVTGYFLGLLGPHMSSLQQAATSFLLLYKTIESAPKSEGKEGE-IK 363

  Fly   424 LNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAG 488
            ::.....|||::|.|:|.|| :..:|..|:|::..||||||||.|||||||.|.|:.:.|....|
Worm   364 ISSTRGNIEFRDVRFKYFTR-DNEVLQGLSLQVLPGQTVALVGTSGCGKSTSIGLLTKLYRASEG 427

  Fly   489 NLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIK 553
            .:|.:|.|:..||...||.:||:|.|||.||..:|.|||:.|| :...|.|:.||..|||:.||:
Worm   428 EILIDGKNIDMLDAKSLRQQIGIVQQEPKLFDGTIMENIKLGR-NVDEETIKTAADIANASSFIE 491

  Fly   554 KLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAG 618
            ||..||:|.:|..|.||||||||||.|||||:..|.||||||||||||:.:|..|..||.|.|.|
Worm   492 KLENGYETRLGPGGVQLSGGQKQRICIARALVTSPSILLLDEATSALDSHNEHIVNKALTKASEG 556

  Fly   619 RTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDI 683
            |||||:|||||:::..|||.|:::|:..|.|||.||:.|...|..|..:|..|....
Worm   557 RTTIIIAHRLSSLKSVDRIYVLDQGKTKEIGTHDELILLGGIYARLAKSQEVEQSSK-------- 613

  Fly   684 YKNFDIKDEDEEEIK--------------------VLSEDEDEDV--MVTDEKNKKKKKKKVKD- 725
                  ||.:.||::                    :|.|.|...|  ::|:.:.:|.....:..
Worm   614 ------KDWEREELRRAEKMKKKGRTVEIIEPNSTILQEHEHNFVGSVITENEEQKISFSGISKL 672

  Fly   726 ----PNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVREN 786
                |...|.::.::.:..|..:::   |...:.|..|.        ..||    :..|.|:..|
Worm   673 FNYLPKHRKTLILIIALLIPRAIEL---CSYGIGMSFAF--------KTLQ----RSKDDYMTWN 722

  Fly   787 ----SNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTG 847
                :.|     .:|||...|.....:|..|.....:...::..|...:|.:.:.:||:......
Worm   723 YITLAQQ-----TLAGITFWILHTSLMYLCGWLANEVMNEVKQEMLSEVLNKPIPYFDNPETSPS 782

  Fly   848 SLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRT 912
            :..:|:...|.........|....|..|:.....:.|:..:.|.||::.|..| .:|..|.:...
Worm   783 ACVSRIISHAHNCYACLDHRAIRFVWFIAGTIFSLLLAFPFVWELGVLGLGIT-ILLTIFSLHFV 846

  Fly   913 LMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHF-RGLV 976
            .:|.........|:...:.|||:|.:||.:..|..|..| :|.....:...||.:....| ..|.
Worm   847 SVAHRAHSEKSVMDKSGEFAVEIVEHIRAIKLLAVEGYF-ENKFSEYLKTSEIYENKIGFVSSLN 910

  Fly   977 YGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAK 1041
            :.:.:|.:|.......:.||..:.|.......||.......|....:.....:.|.:.:|.::|.
Worm   911 FAITQSYVFACDMLLFFVGTLLIYHGRYSPDKVFLAFNGAQMSAWGVMYFSPWFPEIVRGSASAN 975

  Fly  1042 TIFTFLRR----QPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIA 1102
            .||:|..:    ..|.:.:|.::       |.|....|.|:||:.....|.:|..|.:.||..||
Worm   976 QIFSFFDKNRTNSTSGLSKPEIN-------GKVEVSDVTFAYPSTPHRNVCEGFSLNIPKGHSIA 1033

  Fly  1103 LVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENIS 1167
            |||.|||||||.|.:::|||....|...:|:.|:..:.:.:|||.:.:|.|||:||:.||||||:
Worm  1034 LVGASGCGKSTIISMLERFYSAKAGRISVDDNDIDGIDVNHLRNNISVVGQEPVLFNATIRENIT 1098

  Fly  1168 YGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIM 1232
            .|.:  .|:.:|:..|||.:|...||.:.||||||.:||.||.||||||||||||||:||.|||:
Worm  1099 IGID--EVSVEEVQKACKAANAAGFIESFPLGYDTIVGEGGASLSGGQKQRIAIARAIIRKPKIL 1161

  Fly  1233 LLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLA 1297
            ||||||||||.:||::||.||.:|:.|||:|.:|||||||.|.|.|:....|.|.|.|.|.:|:|
Worm  1162 LLDEATSALDTQSEEIVQKALRSATTGRTSIIVAHRLSTVQHCDTIYYISRGAVAEYGTHAELVA 1226

  Fly  1298 NRGLYYTLYKLQS 1310
            ....|..|...||
Worm  1227 MDSKYARLVAAQS 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	409/1286 (32%)
		ABC_membrane	92..382	CDD:279056	67/301 (22%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	126/236 (53%)
		ABC_membrane	750..1020	CDD:279056	56/274 (20%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	122/238 (51%)
pgp-11	NP_001364583.1	PTZ00265	38..1235	CDD:240339	406/1273 (32%)
pgp-11	NP_001364583.1	MdlB	46..607	CDD:224055	202/592 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.690