DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and pgp-14

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_510128.1	Gene:	pgp-14 / 181416	WormBaseID:	WBGene00004008	Length:	1327	Species:	Caenorhabditis elegans

Alignment Length:	1368	Identity:	463/1368 - (33%)
Similarity:	740/1368 - (54%)	Gaps:	140/1368 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KDDVNSRSQYKTNIVLGAKLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYF 74
            |.|....|....|.|     :|.|...|.:.|:..:|...:    |....|.:....:.:.||..
Worm    36 KSDPKIASDLPANYV-----DDDDDAPKMYTPSLLEKILNY----ALCRGDIANQQLEAQPVSIP 91

  Fly    75 QLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLL 139
            .||||..|.|..|..||.:.|:.:|::.|..:|:.|.:.|.::...   .:.|.:|
Worm    92 GLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYP---PTSKQFR--------- 144

  Fly   140 LDKVRQFSLQNTY----IGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQS 200
             :|..    :|.|    |||.:.:.:::...||.:.....:..:|.:|..|:|.|:..|:|.|.|
Worm   145 -NKAN----ENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHS 204

  Fly   201 GEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVA 265
            |.:.:::|:.:.::.:|:.:|:.:.:......:.::|:|::..|:|:.:.|...|...|.|.|:|
Worm   205 GTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLA 269

  Fly   266 VATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIG 330
            ...:....||:.....|..:||.:|.|:|||:||.|:.:.|..|:..:...:...:.:..:||..
Worm   270 RQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKGFWSGFF 334

  Fly   331 FGLLWFFIYASYALAFWYG-----VGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPY 390
            .||.:|::::.......||     ||::.           ..|.:..|..|:::|:..:|:.:|:
Worm   335 GGLFFFWLFSFLGCGMLYGAYLLKVGIIT-----------TPGDVFIVVMSMLLGAYFLGLISPH 388

  Fly   391 IEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLK 455
            :.....|:.:.|.::..|:::|:|:|....||:|...:..::|:.|.|:||:|.:..|||.|||.
Worm   389 MMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLV 453

  Fly   456 IHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFA 520
            :..|.:|||||.|||||||.:.|:.|.|:|:|||:..:||::::|:|.|||:.:|:|.||||||.
Worm   454 VEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFN 518

  Fly   521 TSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALI 585
            .:|:.|:..|...:|||.:......|||..||:|:|||||||:|:.|.|||||||||:||||.||
Worm   519 DTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLI 583

  Fly   586 RDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGT 650
            |||::|||||||||||..||:.||:||...|.|||||::||||||:|.||:||...||.:||:|.
Worm   584 RDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGN 648

  Fly   651 HQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKN 715
            |:||:.|...||:||..|                 .|....|..||.    |:|:.|:..|...:
Worm   649 HEELVRLGGRYFDLVKAQ-----------------QFKADPEATEEF----EEEEIDLDDTSRSS 692

  Fly   716 KKKKKKKVKD--------------------------------PNEVKPM----------LEVMKM 738
            ::......:.                                .||...|          |::.|.
Worm   693 RRSSMTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENSAFAANEAAIMAEDGQITAGYLDIFKN 757

  Fly   739 NKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGI 803
            .|..:|.:.:|.:.::|.|..:|..|::||.:.:..:.......:........:.|...|:.|..
Worm   758 AKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWF 822

  Fly   804 ATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRI 868
            :.......|.:..|.|:.|.|...|..:|.|:.::||:.|:..|.|..||:.||..::.....|:
Worm   823 SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARM 887

  Fly   869 GTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMEN--CTKL 931
            ..::.:::.:...||::..|.|.:|::.   |..||:..::...|..|.::.:.:.::|  ..::
Worm   888 LQVIYALAAIIANIAIAFIYCWQIGILG---TSLILLLAFVMIGLAYKISLMNVEQIQNDDAGRI 949

  Fly   932 AVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLV----YGLARSLMFFAYAACM 992
            |:|::.|::|:..|.|.|:|..:|    ..:.:..||:...:|::    |.|.:|.|:|  ..|.
Worm   950 AIEIIENVKTIQLLTRCELFFDHY----QTSSKQQKRSELKKGMIEAINYSLTQSFMYF--MMCF 1008

  Fly   993 YYGTWC-VIHRGILFG-DVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSI-- 1053
            .|.... :|::|.... |.||...|:::|..::.|:..:.|...|..:||..:|..:.|:|..
Worm  1009 TYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGD 1073

  Fly  1054 ---VDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCI 1115
               .|||.:       .|.:.|:.||||||.|....::|||:....:||.:|||||||.||||.|
Worm  1074 LMEGDRPEI-------RGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 1131

  Fly  1116 QLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEI 1180
            .:::|||||..||..||..|:|.:|:.:||.|:.:|.|||.||..|||||:..|  .::|..::|
Worm  1132 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKI 1194

  Fly  1181 ISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAES 1245
            ..|.:.:|.:.|:||||.|.||.:||||.||||||||||||||||:|:|||:||||||||||:||
Worm  1195 NQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSES 1259

  Fly  1246 EKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQS 1310
            |:.||:|||.|.||||.|:||||||::.:||:|...:.|.|.|||:|.||:..:|.||.|.|.|.
Worm  1260 ERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQD 1324

  Fly  1311 GAM 1313
            .|:
Worm  1325 LAV 1327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	448/1302 (34%)
		ABC_membrane	92..382	CDD:279056	67/298 (22%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	133/236 (56%)
		ABC_membrane	750..1020	CDD:279056	63/277 (23%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	134/238 (56%)
pgp-14	NP_510128.1	PTZ00265	104..1321	CDD:240339	440/1283 (34%)
		ABC_membrane	109..377	CDD:279056	66/295 (22%)
		ABC_MTABC3_MDL1_MDL2	429..666	CDD:213216	133/236 (56%)
		ABC_membrane	769..1039	CDD:294371	64/278 (23%)
		ABC_MTABC3_MDL1_MDL2	1086..1323	CDD:213216	134/238 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5387
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1571
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.640