DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and pgp-12

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_510126.1	Gene:	pgp-12 / 181415	WormBaseID:	WBGene00004006	Length:	1318	Species:	Caenorhabditis elegans

Alignment Length:	1368	Identity:	462/1368 - (33%)
Similarity:	759/1368 - (55%)	Gaps:	120/1368 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNGDVVK--DDVNSRSQYKTNIVLGAKLE-----DSDRDRK-SFEPNKSKKKSKH--DESDASDE 58
            ||||.::  |.:...:..|.:..:....|     |||.:.| .:||:|.:|...:  ...|.:..
Worm     5 KNGDAIEPIDGIPMENGKKKDTTVNVSTEDVGSIDSDEEPKIVYEPSKMEKLINYMLCRGDLASR 69

  Fly    59 EDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLL 123
            |      ..||.|:...|||||.:.|.||...|:..:..:|:..|...:|.||:.|.::
Worm    70 E------LSVKPVTLLGLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLL------ 122

  Fly   124 ESGKSYRADDAISTLLLDKVRQFSLQNTY----IGIIMLVCSYLSITCFNYAAHSQILTIRSKFF 184
                       |.....|.....::.|.:    ||||:|:.:::...||.|........::..:.
Worm   123 -----------IHNATSDDFYDSAMTNVWLFGGIGIIVLIVNFVQYMCFQYCCIRITSKMKQHYI 176

  Fly   185 RSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLV 249
            :|||.|:..|:|.|.||.:.:::::::.::.:|:.:|:.:.:..:|.||..:|::|...|:|:|:
Worm   177 QSILRQNAGWFDKNHSGTLTTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALM 241

  Fly   250 CLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVV 314
            .:...||..:.|.|::.:.|....||:.....|..:||.:|.|:|||:||.|:.:.|..|...:.
Worm   242 MMGIGPLCCVCMSLMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKYTVELG 306

  Fly   315 AAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLV-IKGYHEPAYENYDAGTMITVFFSVM 378
            ..|...|::.::.|:..|:...|:::.:....:||..|: .|....|       |.:..|..|::
Worm   307 KGKSFAIQKGLWGGVFGGIFLLFLFSYFGGGIYYGGQLLRWKIIETP-------GDVFIVVISML 364

  Fly   379 MGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTR 443
            :|:..:|:.:|::.....|:.|.|.::.||::.|:|:....||:|:...:..:.|:||.|:||||
Worm   365 IGAYFLGLISPHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTNVVGKVVFEEVHFRYPTR 429

  Fly   444 PEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSR 508
            .:|.:||.|||.:..|.:|||||.|||||||.:.|:.|.|:|:.|.::.:|.:::.|:|:|||..
Worm   430 KKVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSLNIDWLRKT 494

  Fly   509 IGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGG 573
            :|:|.||||||..:|:.|:..|...||||::......|||..||:|:|.||:|::|:...|||||
Worm   495 VGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGYETMIGDGSVQLSGG 559

  Fly   574 QKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIV 638
            ||||:||||.|||||::|||||||||||..||:.||:||...:.|||||::||||||:|.||:||
Worm   560 QKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTTIMIAHRLSTIREADKIV 624

  Fly   639 VINKGEVVESGTHQELMELKDHYFNLVTTQLG------EDDG----------------------- 674
            ....|.:||||.|:||:.|...|..||..|..      ||:|
Worm   625 FFENGVIVESGNHEELVALGGRYAKLVEAQKFKESDDIEDNGDEHEEETSTVGRHDRLSSRQVSF 689

  Fly   675 -----SVLSPTGDI-----YKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKKKKVKDPNEV 729
                 |:.|...:|     :..|.:|...||   :.:||..|:|            ::|.:.:.|
Worm   690 HKSCESLASADLEIGYASTFNTFTLKTAQEE---IENEDFAEEV------------QRVMEEDGV 739

  Fly   730 --KPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSL 792
              ...|::.|..:..:|.::||...:::.|..:.:.|.:||.:..... :..|:.|:.....:.|
Worm   740 INSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALLANMFGFVFAAFK-EPEDEMVKALGLIFIL 803

  Fly   793 YFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDA 857
            |..: |:.|.|...:....|.|..|.|..:.|...|:.:|.|:.::||:.|:..|.|..||:.||
Worm   804 YVAL-GLFVFITQVISGTLFTIVAENLGLKFRVQSFKNLLYQDASFFDNPAHAPGKLITRLASDA 867

  Fly   858 AAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTL---MAKENM 919
            ..|:.....|:..::.||:::.:.:.....:.|.   :|:|.|..|::...|..::   :|:||:
Worm   868 PNVKAVVDTRMLQVIYSITSITINLITGYIFCWR---IAIAGTIMIVLFATMMISMAYKIARENL 929

  Fly   920 GSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLM 984
            ...: .:...|:|:|::.:::|:..|...:.|..:|....:...:...|.::.:.:...::::.|
Worm   930 KQIR-KDEAGKIAIEIIESVKTIQLLTSTQRFLTHYKDAQLVQHKSEMRKSYIQSVNNAISQTFM 993

  Fly   985 FFAYAACMYYGTWCVIHRGILFGD-VFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLR 1048
            :||...|...||..:.| ||:..: .|:....::||:.::.::....|...|..:||..:|..:.
Worm   994 YFAMFVCYGVGTPLMYH-GIVEAEPTFRAINCMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLIY 1057

  Fly  1049 RQPSIVDRPGVSRDPWHSE--GYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGK 1111
            |:    .:.|...:..::|  |.|.|:.||||||.|....|:..|..:...||.:|||||||.||
Worm  1058 RK----SKTGDVMEGNNTEIRGNVLFESVKFSYPQRPMQPVMTDLHFSAHSGQTVALVGPSGTGK 1118

  Fly  1112 STCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVT 1176
            ||||.:::|||||..||..||..:::::|:.:||.|:.:|.|||.||..||:||:.:|  .::|:
Worm  1119 STCIAMLERFYDVSGGALRIDGQNIKSLSLHHLRTQMALVGQEPRLFAGTIKENVCFG--LKDVS 1181

  Fly  1177 DQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSAL 1241
            .:::..|.:.:|...|:||||.|.||.:||||.||||||||||||||||:|:|||:|||||||||
Worm  1182 VEKVHQALELANASRFLANLPAGIDTEVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSAL 1246

  Fly  1242 DAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLY 1306
            |:|||:.||:|||.|.||||.|:||||||::.:||:|...::|:|.|||:|..|::.||.||.|.
Worm  1247 DSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDHGMVQEAGNHAHLMSLRGKYYNLI 1311

  Fly  1307 KLQ 1309
            |.|
Worm  1312 KKQ 1314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	442/1290 (34%)
		ABC_membrane	92..382	CDD:279056	70/294 (24%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	127/236 (54%)
		ABC_membrane	750..1020	CDD:279056	60/273 (22%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	131/238 (55%)
pgp-12	NP_510126.1	ABC_membrane	97..332	CDD:279056	61/251 (24%)
		PTZ00265	145..1312	CDD:240339	422/1201 (35%)
		ABC_MTABC3_MDL1_MDL2	417..654	CDD:213216	127/236 (54%)
		ABC_membrane	762..1005	CDD:294371	53/248 (21%)
		ABC_MTABC3_MDL1_MDL2	1077..1314	CDD:213216	131/238 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5387
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.690