DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and pgp-4

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_001257142.1	Gene:	pgp-4 / 181327	WormBaseID:	WBGene00003998	Length:	1280	Species:	Caenorhabditis elegans

Alignment Length:	1302	Identity:	473/1302 - (36%)
Similarity:	737/1302 - (56%)	Gaps:	82/1302 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPAN 105
            |:|.||||:..:.:                 |...|||::...|..|.:.||:.:.|.|...|.|
Worm    28 PDKKKKKSRSSQGN-----------------SLSNLFRHSGCADYLLLLGGLVLSAANGALLPFN 75

  Fly   106 SLIFGNLANDMIDLGGLLESGK-SYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFN 169
            ||||..:.|.::......::|. .|   |..|:    .::.:.|....:|::|..|:|.|..|..
Worm    76 SLIFEGITNVLMKGEAQWQNGTFDY---DTFSS----GIQHYCLLYFLLGVLMFTCTYFSNACLF 133

  Fly   170 YAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVG 234
            ..|..::..||....:|:|.||.||:|.|..|.:..:|:..:.|::||:.:|:.:.|..:..|:.
Worm   134 TMAERRLYCIRKHLLQSVLRQDAKWFDENTVGGLTQKMSSGIEKIKDGIGDKIGVLVSGIATFIS 198

  Fly   235 SLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAF 299
            .:.|.|...|||:||.|.::||...:|.|.|...:|..|.|::.|:.|..:|...::|||||.||
Worm   199 GVALGFYMCWQLTLVMLVTVPLQLGSMYLSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAF 263

  Fly   300 EGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYEN 364
            ..:..|:..|..::..|:.:.|::.:...:...:..|.::...|.|||||..|.       :|..
Worm   264 NAQPFEIERYGAQLAKARKMGIRKAIVLALCSAMPLFLMFVLMAGAFWYGAILT-------SYGV 321

  Fly   365 YDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLT 429
            ..:||...||::|::|:..:|.|||::.|...|:.|...:|.:|:..||||....||::.::...
Worm   322 ATSGTTFGVFWAVILGTRRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNG 386

  Fly   430 TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNG 494
            .:.|..::|.|||||:|.||..::.:::.|:|:||||.|||||||.|.|:.|||:..||::..:|
Worm   387 KLVFDNIQFTYPTRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDG 451

  Fly   495 TNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGY 559
            ..::|.:|.||||.||:|.||||:|..::.||:|.|.:..|.::||.|...|||..||.||.:||
Worm   452 IPIEDYNIQWLRSTIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEGY 516

  Fly   560 DTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIV 624
            :|::|....|||||||||:|||||::|.|:|||||||||||||.||..||.||:|.|.||||:.:
Worm   517 NTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 581

  Fly   625 AHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLV-----------TTQLGEDDGSVLS 678
            ||||||:|.|.:|:|.::|.:.|.|.|.:|:.....|.|:|           |||  :||..|..
Worm   582 AHRLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQEIEKAKDDTTQ--DDDELVEE 644

  Fly   679 PTGDIYKNFDIKDEDEEEIKVLSEDEDE--------DVMVTDEKNKKKKKKKVKDPNEVKPMLEV 735
            ....|.:.....:|:..:.|.|..|...        ...|.|.:.:..:::.:::......|:::
Worm   645 DNYSISRRLSTSEEELRKSKSLLRDSTRFSQSMLSVTSQVPDWEMESAREEMIEEGAMEASMMDI 709

  Fly   736 MKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIV 800
            .:..|||.:.|.:..|.::|.|...|.|:|::|.:.::.:....|..|  |:...||:|::..:.
Worm   710 FRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLFKVFAEGGEDLPV--NALISSLWFVLLAVT 772

  Fly   801 VGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATG 865
            ..:.||:.....|..||.::.|||..:|:.:::|:..:|||..:..|:|.:||:.|:..||.|..
Worm   773 SAVTTFISGSLLGKTGETMSSRLRMDVFKNIMQQDATYFDDPKHNVGNLTSRLATDSQNVQAAID 837

  Fly   866 QRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMEN--- 927
            .|:..::..:.:|..|||::.::.||:..:.|.....::||   |..:.........|.||:
Worm   838 HRLAEVLNGVVSLFTGIAVAFWFGWSMAPIGLITALLLVIA---QSAVAQYLKYRGPKDMESAIE 899

  Fly   928 CTKLAVEVVSNIRTVASLGREE-MFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMF------ 985
            .:::..|.:||.:||.:|.::| |||         |...:.:|...|....||.:||.|
Worm   900 ASRIVTESISNWKTVQALTKQEYMFH---------AFTAASKNPRKRAFTKGLWQSLSFALAGSF 955

  Fly   986 --FAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLR 1048
              :.:|....:|.|.:.:.......||:|.:||.|.:.|:..|.::.|...:...:|..:||.:
Worm   956 FLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMASMSVMMAASYFPEYVRARISAGIMFTMI- 1019

  Fly  1049 RQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKST 1113
            ||.:.:|..|::.:.....|.:....|.|:||.|:...:|....::...|:.:||||||||||||
Worm  1020 RQKAKIDNRGLTGETPDIRGDISMKGVYFAYPNRNRQLILNNFNMSAQFGETVALVGPSGCGKST 1084

  Fly  1114 CIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQ 1178
            .||||:|:||...||..||:.|:|::|:.:||:.:.:|.|||.||:.||||||:||  ..||:.:
Worm  1085 SIQLIERYYDAICGAVKIDDHDIRDISVKHLRHNIALVGQEPTLFNLTIRENITYG--LENVSQE 1147

  Fly  1179 EIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDA 1243
            ::..|...:|||.|:.|||.||||.:|..|.:||||||||||||||::|||||:||||||||||.
Worm  1148 QVEKAATLANIHSFVENLPEGYDTSVGASGGRLSGGQKQRIAIARAIVRNPKILLLDEATSALDT 1212

  Fly  1244 ESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKL 1308
            ||||:||:|||.|..|||.:.|||||||:.::|.|.|..||...|.|.|:.|||.|||||.|.:.
Worm  1213 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEK 1277

  Fly  1309 QS 1310
            ||
Worm  1278 QS 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	465/1270 (37%)
		ABC_membrane	92..382	CDD:279056	85/290 (29%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	124/247 (50%)
		ABC_membrane	750..1020	CDD:279056	75/281 (27%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	131/238 (55%)
pgp-4	NP_001257142.1	ABC_membrane	65..338	CDD:279056	83/286 (29%)
		PTZ00265	68..1276	CDD:240339	456/1240 (37%)
		ABC_MTABC3_MDL1_MDL2	389..625	CDD:213216	123/235 (52%)
		ABC_membrane	724..993	CDD:279056	75/282 (27%)
		ABC_MTABC3_MDL1_MDL2	1041..1278	CDD:213216	131/238 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm4744
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.830