DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and pgp-3

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_509901.1 Gene:pgp-3 / 181326 WormBaseID:WBGene00003997 Length:1268 Species:Caenorhabditis elegans


Alignment Length:1302 Identity:479/1302 - (36%)
Similarity:733/1302 - (56%) Gaps:115/1302 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 EDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYR 130
            :|..|.::|.:||.|..||..|:..||:.:...|...|.|||||..:||      .|:|....|:
 Worm    24 QDSYQGNFFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIAN------ALMEGESQYQ 82

  Fly   131 ADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWY 195
            ...........:::.|.|:..|:|:.:.:|||.:.:|.......::..||.|:.:|:|.||.||:
 Worm    83 NGTINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWF 147

  Fly   196 DFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIA 260
            |....|.:..:|:..:.|::||:.:||.:.|..:..|:..:.:.|...|||:||.:.::||...:
 Worm   148 DETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPLQLGS 212

  Fly   261 MGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNM 325
            |.|.|...:|..|.|::.|:.|..:|...::|||||.||..:..|:..|..::..|:.:.|::.:
 Worm   213 MYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRKAI 277

  Fly   326 FSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPY 390
            ...|........::...|:|||||..|...|       ...:|.:..||::|::|:..:|.|||:
 Worm   278 ILAICTAFPLMLMFTCMAVAFWYGATLAAAG-------AVSSGAVFAVFWAVLIGTRRLGEAAPH 335

  Fly   391 IEAFGIAKGACAKVFHIIEQIPEINPIDGEGK---KLNEPLTTIEFKEVEFQYPTRPEVSILNKL 452
            :.|...|:.|...:|.:|:..|||.....|||   |:...||   |..:||.||||||:.||..:
 Worm   336 LGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLT---FDGIEFTYPTRPELKILKGV 397

  Fly   453 NLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPI 517
            :.:::.|:||||||.|||||||.|.|:.|||:..||.:..:|..:::.:|.||||.||:|.||||
 Worm   398 SFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRSTIGIVQQEPI 462

  Fly   518 LFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIAR 582
            :|..::.||||.|....|.::||.|...|||..||.||...|||::|....|||||||||:||||
 Worm   463 IFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAGAVQLSGGQKQRVAIAR 527

  Fly   583 ALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVE 647
            |::|.|:|||||||||||||.||..||.||:|.|.||||:.:||||||:|.|.:|:|.::|.:.|
 Worm   528 AIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHRLSTIRNASKILVFDQGLIAE 592

  Fly   648 SGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIK---VLSEDEDEDV- 708
            .|||.||              :.:|||        ||.:. :|.::.|..|   .|.::|||.. 
 Worm   593 RGTHDEL--------------ISKDDG--------IYASM-VKAQEIERAKEDTTLDDEEDEKTH 634

  Fly   709 ------MVTDEKNKKKKKKKVKDPNEVK------------------------------PMLEVMK 737
                  .||.::.::.::...:|...::                              .:.::.|
 Worm   635 RSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIEEGAMEASLFDIFK 699

  Fly   738 MNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVG 802
            ...||...|.:..:.::|.|...|.|::::|.:.:|||...:|..::...|  ||:|::.....|
 Worm   700 YASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALLN--SLWFILLAFTGG 762

  Fly   803 IATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQR 867
            |:|.:.....|.|||.::.|||..:|..:::|:.::|||..:..|||.:||:.||..||.|..||
 Worm   763 ISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQR 827

  Fly   868 IGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFIL------IAFYMQRTLMAKENMGSAKTME 926
            :..::..|.:|..|:.::.||.|::..:.|| |..:|      :|.|::  ...:.:|.||   .
 Worm   828 LAEVLTGIVSLFCGVGVAFYYGWNMAPIGLA-TALLLVVVQSSVAQYLK--FRGQRDMDSA---I 886

  Fly   927 NCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMF------ 985
            ..::|..|.:||.:||.:|.::|..:.        |...:.::.|.|.:|.||.:||.|      
 Worm   887 EASRLVTESISNWKTVQALTKQEYMYD--------AFTAASKSPHRRAIVRGLWQSLSFALAGSF 943

  Fly   986 --FAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLR 1048
              :.:|....:|.|.:.:.......||:|.:||.|.:.|:..|.::.|...:...:|..:||.: 
 Worm   944 VMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMI- 1007

  Fly  1049 RQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKST 1113
            ||.|::|..|::.|....:|.:....|.|:||.|....||.|..::.:.||.:||||||||||||
 Worm  1008 RQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKST 1072

  Fly  1114 CIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQ 1178
            .||||:|:||...|:..||:.|:|::|:.:||:.:.:|.|||.||:.||||||:||  ..|:|..
 Worm  1073 TIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYG--LENITQD 1135

  Fly  1179 EIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDA 1243
            ::..|...:|||.|:..||.||||.:|..|.:||||||||:|||||::|:|||:||||||||||.
 Worm  1136 QVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 1200

  Fly  1244 ESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKL 1308
            ||||:||:|||.|..|||.:.|||||||:.::|.|.|..||...|.|.|:.|||.|||||.|.:.
 Worm  1201 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEK 1265

  Fly  1309 QS 1310
            ||
 Worm  1266 QS 1267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 476/1295 (37%)
ABC_membrane 92..382 CDD:279056 82/289 (28%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 124/236 (53%)
ABC_membrane 750..1020 CDD:279056 81/283 (29%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 130/238 (55%)
pgp-3NP_509901.1 ABC_membrane 50..326 CDD:279056 81/288 (28%)
PTZ00265 105..1264 CDD:240339 451/1210 (37%)
ABC_MTABC3_MDL1_MDL2 377..614 CDD:213216 131/262 (50%)
ABC_membrane 712..981 CDD:279056 81/284 (29%)
ABC_MTABC3_MDL1_MDL2 1029..1266 CDD:213216 130/238 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 151 1.000 Domainoid score I2660
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm4744
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.730

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