DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and pgp-6

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_001041287.2	Gene:	pgp-6 / 181278	WormBaseID:	WBGene00004000	Length:	1263	Species:	Caenorhabditis elegans

Alignment Length:	1296	Identity:	436/1296 - (33%)
Similarity:	691/1296 - (53%)	Gaps:	99/1296 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 SDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLG 120
            |||:..||....::.|     |:.::..::.|:::|:|.::.||...|..|..||.::..::.:.
Worm    16 SDEKKPSQICSFIRVV-----FKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTIT 75

  Fly   121 GLLESGKSYRADDAISTLLLDKV---RQFSLQNTYIGIIMLVCSY-----LSITCFNYAAHSQIL 177
            ..:.:.....||       |:|.   .:..:........:..|:|     |......|...:...
Worm    76 NAINNKTIDPAD-------LEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTY 133

  Fly   178 TIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVK 242
            .:|.::...:|.:|.:::|...:|.:::.:|::|.:..:...||:.:.:.::..|.....|||..
Worm   134 RVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYT 198

  Fly   243 GWQLSLVCLTSLPLTFIAMGLV------AVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEG 301
            .|:|:...:      |.::|:.      :....:...|:.|.||.|..:|...|...:||.:..|
Worm   199 DWRLASYGI------FFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNG 257

  Fly   302 EAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYD 366
            :..|:..|.|.:.|.:...|:|.:...|..|:.:||..:...:..:.|..::..|..|.|
Worm   258 QKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETA----- 317

  Fly   367 AGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLN---EPL 428
              .::.:|..::.|:..:..|.|:|.....|..:.|.:..::  |.:.|.|:.:....:   |..
Worm   318 --VVVRLFHYMLFGAFCLSEALPHISRLAGAISSTAPIAEML--IKDDNVIEKDETDYDVEVEVN 378

  Fly   429 TTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFN 493
            ..|.||.|:|.|||||:..:|..::..:..|:.:||||.||.||||.:||:..:|:..:||:..:
Worm   379 GNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFID 443

  Fly   494 GTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKG 558
            |.:|.|::|..||..||||.|||:||.|:|.||||:|..:.:..||..|...|||..|:...|||
Worm   444 GMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 508

  Fly   559 YDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTII 623
            ..|:|||||.||||||||||||||.|:|:|:||||||||||||..||..||.|||..|.|||||:
Worm   509 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIV 573

  Fly   624 VAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGE--DDGSVLSPTGDIYKN 686
            |||||||:|.|.:|:|:.|||:||.|.|.||:..:..|.:||..||.|  ||...|.|......:
Worm   574 VAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLS 638

  Fly   687 FDIKDEDEEEIKVLSEDE----DEDV-MVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQI 746
            .::.......|:..:.::    |:|: .:.||.:|:..||        ..:.|::|..:|::..:
Worm   639 QELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKK--------SNLREIVKQCRPDYCFL 695

  Fly   747 AVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVREN----SNQYSLYFLIAGIVVGIATFL 807
            .:....|.|.|.:.||.|.|      |:...:....:.|:    |:.::|.|:...:...:..:.
Worm   696 FIAVFGSAIQGVSYPILAQL------IVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYC 754

  Fly   808 QIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIV 872
            |.|:||...|:|:.|||...|..||....|::||..:....|..||:.|::.|:.|...|:|.::
Worm   755 QYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVI 819

  Fly   873 QSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVS 937
            .::..:::.|..:..|.|.:.|..|.|.|.:.:|.|.................||..:.|:|.:.
Worm   820 MTVVAISIAITTASLYCWKMTLEVLMFFPLLYLAEYCYEAATETAIQEDTIAFENSNRTAIEALE 884

  Fly   938 NIRTVASLGRE-----------EMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAAC 991
            |:|||.:|..|           :..|::|....|           .:|...||:.|...|.|:..
Worm   885 NVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAI-----------IQGAANGLSLSCFLFVYSVS 938

  Fly   992 MYYGTWCVIHRGILFGDVFKVSQALIMGTASIA-NALAFAPNMQKGVSAAKTIFTFLRRQPSIVD 1055
            ..:||:..:.:.:...|.:.|...|.| ||::| :|.|:.|:.:|.|.||..|| .|...|:.:
Worm   939 FKFGTYLALRKEVAPMDTYLVLMTLSM-TANMAGSAAAYLPDYKKAVHAAGLIF-HLFTYPATM- 1000

  Fly  1056 RPGVSRDPWHS--EGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLI 1118
             |..|.|...:  :|.:..:.|:|.|..|.:..:|.|:.|.|..|:.:||||||||||||.|.|:
Worm  1001 -PFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLL 1064

  Fly  1119 QRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISA 1183
            :|||...:|...||..:|.::::.:||:.|.:|||||.||:.:||||:.|| ..|:|...|:..|
Worm  1065 ERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKA 1128

  Fly  1184 CKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKV 1248
            .:.:|...|:...|.|.||.:||:|||||||||||||||||::||||::||||||||||::||||
Worm  1129 LQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKV 1193

  Fly  1249 VQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQ 1309
            ||:|||.|||..:|:.:||||||||::|.|.|.:||.|.|.|.|::||..|.:|:.|.:.|
Worm  1194 VQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	430/1280 (34%)
		ABC_membrane	92..382	CDD:279056	58/303 (19%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	130/236 (55%)
		ABC_membrane	750..1020	CDD:279056	69/284 (24%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	124/238 (52%)
pgp-6	NP_001041287.2	PTZ00265	32..1252	CDD:240339	429/1271 (34%)
		ABC_membrane	47..331	CDD:294371	58/303 (19%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	130/236 (55%)
		ABC_membrane	699..970	CDD:279056	71/288 (25%)
		ABC_MTABC3_MDL1_MDL2	1019..1254	CDD:213216	124/235 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830