DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and pgp-5

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_001257116.1	Gene:	pgp-5 / 181276	WormBaseID:	WBGene00003999	Length:	1252	Species:	Caenorhabditis elegans

Alignment Length:	1294	Identity:	436/1294 - (33%)
Similarity:	684/1294 - (52%)	Gaps:	135/1294 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGN-----------LANDMIDLGGLLESGKSY 129
            :.:..|:.::.|:.:|::.::.||:..|..|...|.           :.|..||...|..:.|.:
Worm    25 IIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLF 89

  Fly   130 RADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKW 194
            .:|.....||      |.|    :|.......:|..:...:...:....:|.::...:|.:|:.:
Worm    90 ESDMNRVVLL------FFL----VGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISY 144

  Fly   195 YDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCL-TSLPLTF 258
            :|...:|.::..:|:::.:..:...||:.:.:..|..||...:|||...|:|:  |. |......
Worm   145 FDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLA--CYGTVFSFGI 207

  Fly   259 IAMGLV-AVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIK 322
            :..||: :....:..:|:....:.|..:|..||...:||.:..|:.:||..|.|.:...:...:.
Worm   208 VLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 272

  Fly   323 RNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMA 387
            |.....:.....:||..|...:..::|..::.:|..||       |.::.:.:.::.||..:|.|
Worm   273 RAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEP-------GVVVRILYYILFGSYCLGEA 330

  Fly   388 APYIEAFGIAKGACAKVFHIIEQIPEINPI-----DGE-------GKKLNEPLT-TIEFKEVEFQ 439
            ..:|.....|             ||...||     |.:       .:::.:... .|.||.|.|.
Worm   331 ILHISRLASA-------------IPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFS 382

  Fly   440 YPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINW 504
            |||||:|.:|.:::..:..|:.:||||.||.||||.|||:..:|:..:|.:..:|.::.:::|..
Worm   383 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 447

  Fly   505 LRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQ 569
            ||..:|||.|||:||.|||.||||:|:.|||.:||..|...|||..|:...|.|..|:|||||||
Worm   448 LRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQ 512

  Fly   570 LSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRA 634
            |||||||||||||.|:|:|.||||||||||||..||..||.||:|.|.|||||:|||||||:|.|
Worm   513 LSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNA 577

  Fly   635 DRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEI-- 697
            ::|:|:.|||:||.|.|::|:.:...|.|||.|||             :..|::..:|:||.:
Worm   578 NKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQL-------------MSTNYEKMNENEERVTR 629

  Fly   698 ---------------KVLSEDEDEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIA 747
                           |:..||:....::.:.|.:..||..:         .|::|..:.|:..:.
Worm   630 QSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNI---------CEIIKYCRSEYCILF 685

  Fly   748 VGCISSVIMGCAMPIFAVLFGSILQILSVK----DNDQYVRENSNQYSLYFLIAGIVVGIATFLQ 808
            :..:.|.|.|...|:     .|.|.|.|.:    |.|:.: ..|:.::|..|.......|..|.|
Worm   686 IAVLGSAIQGIYYPL-----SSQLMIKSYEAYAFDKDEML-SKSHFWALSILFLAFTRPIFIFFQ 744

  Fly   809 IYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQ 873
            .||||...|:|:.:||.:.|:.::....|::||..:....|..||:.|::.|..|...|:|:::.
Worm   745 YYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIM 809

  Fly   874 SISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSN 938
            ::..:.|.:.:|.:|.|.:.|..|.|.|.:.:|.|.....:.:.....:...|...:.|:|.:.|
Worm   810 TLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALEN 874

  Fly   939 IRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFR-----GLVYGLARSLMFFAYAACMYYGTWC 998
            :|||.:|..|     |.:.:|:.:.....||::|:     |...|.|.|..||.||....:|||.
Worm   875 VRTVRALNME-----NRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWL 934

  Fly   999 VIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDP 1063
            |:...||..|.:.|...|.|..:...:|:|:.|:.:|.:.||..|| .|...|:|:        |
Worm   935 VLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF-HLFTYPAIM--------P 990

  Fly  1064 WHS--------EGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQR 1120
            :.|        .|.:....|.|.|..||:..:|.|:.|.:..|:.:|||||||.||||.|.|::|
Worm   991 YDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLER 1055

  Fly  1121 FYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACK 1185
            ||...:|...|||.:|.:|::.:||..:.:|||||:||:.:|:||..:| .:.|.:..||..|.|
Worm  1056 FYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG-ISHNASQLEIDQALK 1119

  Fly  1186 KSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQ 1250
            .:|...|::..|.|.||.:||:|||||||||||||||||::||||::||||||||||::||||||
Worm  1120 VANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQ 1184

  Fly  1251 DALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQ 1309
            :|||.|||..:|:.:||||||||::|.|.|.:||.|.|.|.|::||..|.:|:.|.:.|
Worm  1185 NALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	435/1291 (34%)
		ABC_membrane	92..382	CDD:279056	59/302 (20%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	132/236 (56%)
		ABC_membrane	750..1020	CDD:279056	78/278 (28%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	123/238 (52%)
pgp-5	NP_001257116.1	PTZ00265	27..1241	CDD:240339	435/1288 (34%)
		ABC_membrane	41..322	CDD:294371	58/299 (19%)
		ABC_MTABC3_MDL1_MDL2	374..611	CDD:213216	132/236 (56%)
		ABC_membrane	688..955	CDD:294371	77/277 (28%)
		ABC_MTABC3_MDL1_MDL2	1005..1243	CDD:213216	123/238 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830