Protein Alignment Mdr50 and mrp-4

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_509658.1
• Gene: mrp-4 / 181202
• WormBaseID: WBGene00003410
• Length: 1573
• Species: Caenorhabditis elegans
• Alignment Length: 1488
• Identity: 305/1488 - (20%)
• Similarity: 593/1488 - (39%)
• Gaps: 360/1488 - (24%)

  Fly    12 DVNSRSQYKTNIVLGAKLEDS-DRDRKSFEPNKSKKK-------------SKHDE----SDASDE 58
            |:.|.::..|:.:|..|..:. |:..|.||...::::             |.:|.    :|.|.:
 Worm   249 DLYSLNEADTSNLLVPKWYNLWDKQSKKFEETAARRRIGSNASRTNRRRTSSNDTTPLLNDQSTD 313

  Fly    59 EDGS----QYHEDVKQV--SYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMI 117
            :.||    |..:.:..:  :.|.:|::..  ..|::| .|||.|...    .|.|:..:|.....
 Worm   314 DYGSVPAGQSTQKMPSIIWTLFLMFKWDV--ITAMFV-KLLSDVLLF----CNPLLLKSLIRFTE 371

  Fly   118 DL------GGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQI 176
            :|      |.:|.....:.|:  :|::||         :.|..::..|.:.:. ||...|.:.:.
 Worm   372 ELERPMWQGVVLAFTMFFSAE--LSSILL---------SHYFYLMYRVGTRVQ-TCLTAAVYRKT 424

  Fly   177 LTI-----RSKF--------------FRSILHQDMK-WYDFNQSGEVASRMNEDLS-KMEDGLAE 220
            |.:     |.|.              |:.|..|.|: |.:..|.|.....:.:.|. .:..|:|.
 Worm   425 LRLSNAARREKTVGEIVNLMAIDVDRFQQITPQTMQYWSNPFQIGLALFLLFQQLGVSVFSGVAV 489

  Fly   221 KVVMF-VHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAV 284
            .|::| :::::..:       ::.||::                     ....|.|.|.
 Worm   490 MVLLFPINFVITMI-------IRKWQIA---------------------QMYYKDERTK------ 520

  Fly   285 VAEGALSGIRTVKAFEGE-----------AKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFI 338
            :....|:||:.:|.:..|           .:|:...|:    |..|....:|.:.....|:....
 Worm   521 MVNEVLNGIKVIKLYAWEPPMEQVIEDLREQELGLIKK----AAFLRTFSDMLNTASPFLVALST 581

  Fly   339 YASY-----------ALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIE 392
            :|::           .:||   |.|.:  :::..........:||....|::.:..:
 Worm   582 FATFIYIDPKNVLTPEIAF---VSLTL--FNQLRSPMSQVAELITQTVQVVVSNRRL-------- 633

  Fly   393 AFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPL----TTIEFKEVEFQYPTRPEVSILNKLN 453
                      |.|.:.|:: .:..||...:..|:.:    ..:.::..|.|     .|..|..::
 Worm   634 ----------KEFLVSEEL-NVEAIDHRARDNNDVICLKEACLSWESAEHQ-----PVPTLTNIS 682

  Fly   454 LKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPIL 518
            ..::|||.|.:||..|.|||:.:|.:....:..:|::..:|             |:..|.|:|.:
 Worm   683 FSVNRGQLVTIVGRVGAGKSSMLQALMGEMEKLSGSISMHG-------------RLCYVPQQPWM 734

  Fly   519 FATSIYENIRYGR---EDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAI 580
            ...::.:||.:|:   |......::|.|...:..|    ||.|.:|.:||:|..||||||.||::
 Worm   735 QNNTLRQNITFGKQFDEYFYSRVLDACALYRDLQI----LPLGDNTEIGEKGINLSGGQKARISL 795

  Fly   581 ARALIRDPEILLLDEATSALDTASEAKVQAAL---EKVSAGRTTIIVAHRLSTVRRADRIVVINK 642
            |||:.::.:|.|||:..||:|....:::..::   |.:...:|.|:|.:.||.:.::|.|:|:|:
 Worm   796 ARAVYQNHDIYLLDDPMSAVDAHVGSQLFGSVIGPEGMLRNKTRILVTNELSFLEKSDLIIVMNE 860

  Fly   643 GEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEE---IKVLSEDE 704
            |::..||.:.:||:.......|:..:..|.:......:.|       :|::..|   |.:..:.:
 Worm   861 GKIEYSGKYDDLMQQGAFEQLLIECEKEERERREAEASAD-------EDDENSEPGGIMIGGDSD 918

  Fly   705 ---DEDVMV----------------------------TDEKNKKKKKKKVKDPNEVKPMLEVMKM 738
               |:|||.                            |.::.::....|....:......:..::
 Worm   919 FEYDDDVMASPIIDHVLGTSHMSTVSGIINRRRISTSTHKQRRRLSTTKSHTHSITSASTQTRQL 983

  Fly   739 NKPEWLQIAVGCISS-------VIMGCAMPIFAVLFGSILQILSVK--------DNDQYVRENSN 788
            ...|  ::..|.:..       ..||.::.:..||..:...|.|:.        .||...|..||
 Worm   984 TGTE--RVETGRVKMDTYYKYFGAMGMSIAVLFVLGMTTSTIFSMGRNLWLTDWSNDNAARSGSN 1046

  Fly   789 QYSLYFLI-AGIVVGIA---------TFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKA 843
            .......| .|:..|:.         ..|.:.:.|::..|   .|...:...:.|..:|::|  .
 Worm  1047 TTGQPIAIRLGVYAGLGFSEIILLFIGMLSLLYGGVSASR---NLHAPLMRNLFRVPMAFYD--T 1106

  Fly   844 NGTGSLCARLSGDAAAVQ-----------GATGQRIGT-IVQSISTLALGIALSMYYEWSLGLVA 896
            ...|.:..|:..|...|.           ....|.:.| |:..|||...||.          ::.
 Worm  1107 TPFGRILNRIGKDIETVDVLLPFNVQFFAQCLLQVVSTLIIIMISTPVFGIV----------IIP 1161

  Fly   897 LAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAV-----EVVSNIRTVASLGREEMFHQNYI 956
            |:....:::.:|:..:...|.       :|:.|:..:     |.:....|:.:....:.|.:
 Worm  1162 LSVMYLMVMRYYIATSRQLKR-------LESITRSPIYSHLSESIQGSATIRAYHLVDRFCK--- 1216

  Fly   957 GMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTW----------CVIHRGILFGDVFK 1011
                  :..:|.::|.:      .|.|.:.|       ..|          |:    :||..:|.
 Worm  1217 ------LSETKVDSHVQ------CRYLNYVA-------NRWLSVRLEFIGNCI----VLFSALFA 1258

  Fly  1012 VSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDR----------------PGVS 1060
            ........:..|..::::|.|:...::.|....|.|......|:|                ||
 Worm  1259 ALTRTTTTSGVIGLSVSYALNITTVLNFAVRQITKLETNIVSVERVKEYAETETEAEWKSEPG-- 1321

  Fly  1061 RDP---WHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFY 1122
            ::|   |.|||.:..:.....|.....: |:|.|.:.:...:|:.:||.:|.|||:....:.|..
 Worm  1322 KEPPQNWPSEGRIVMNNYSARYRPGLNL-VVKQLNVEIKPHEKVGIVGRTGAGKSSVTLSLFRII 1385

  Fly  1123 DVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKS 1187
            :..||..::|..::..:.:.:||:.|.|:.|:|:||..|:|.|:   |...:.:|.:|....:.:
 Worm  1386 EAAEGQIVVDGINLAEIGLHDLRSNLTIIPQDPVLFSGTLRFNL---DPFNHYSDGDIWKTLEMA 1447

  Fly  1188 NIHEFIA--NLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQ 1250
            |:.||..  |..|.|  .:.|.|..:|.||:|.:.:||||:|..::::|||||:|:|..::.::|
 Worm  1448 NLKEFATAHNEQLNY--IITEGGDNISVGQRQLVCLARALLRKTRVLILDEATAAVDVSTDALIQ 1510

  Fly  1251 DALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGL-YYTLYK 1307
            ..:.......|.::|||||:|::..|.|.|..:|.|.|......||:||.. :|::.|
 Worm  1511 KTIREEFANATVLTIAHRLNTIMDYDRIIVLNDGKVGEFDSPANLLSNRNSEFYSMAK 1568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	289/1409 (21%)
		ABC_membrane	92..382	CDD:279056	58/339 (17%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	69/242 (29%)
		ABC_membrane	750..1020	CDD:279056	51/321 (16%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	73/241 (30%)
mrp-4	NP_509658.1	MRP_assoc_pro	17..1572	CDD:188098	305/1488 (20%)
		ABC_membrane	346..613	CDD:294371	56/326 (17%)
		ABCC_MRP_domain1	658..862	CDD:213217	63/225 (28%)
		ABC_membrane	1012..1259	CDD:294371	49/294 (17%)
		ABCC_MRP_domain2	1332..1552	CDD:213211	68/225 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000