DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and pgp-10

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_509205.2 Gene:pgp-10 / 180981 WormBaseID:WBGene00004004 Length:1382 Species:Caenorhabditis elegans


Alignment Length:1445 Identity:412/1445 - (28%)
Similarity:677/1445 - (46%) Gaps:222/1445 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 SRSQYKTNIVLGA--KLEDSDRDRKS-------FEPN-------KSKKKSKHDESD-----ASDE 58
            :.|..|||.:..|  |.|....|:||       .||:       |:.||:.....|     :||.
 Worm     8 NESTNKTNEIGNAEKKEEAETEDKKSLKSMIYPIEPSTLYIDDLKNSKKAYDVTMDDPLDKSSDS 72

  Fly    59 EDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLL 123
            :....:.|     .|.:|:.:|...|..|..:||.||:......|...||.||    .:.:..|.
 Worm    73 KPKLGFFE-----PYKRLYAFADSIDMQLMAMGLFSALLQSALPPFVWLIMGN----FVSISILR 128

  Fly   124 ESGK--------SYRADDAISTLLLDKVRQFSLQNT-------YIGIIMLVCSYLSITCFNYAAH 173
            |.||        .|..||           ||:...|       .:.|.|.:.::.....:..::.
 Worm   129 EEGKLGLKNLTSDYPIDD-----------QFAHSATPAFISMLGLSIAMFIAAFCQRIAWEISSI 182

  Fly   174 SQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAE---KVVMFVHYLVAFVGS 235
            .|:..|:..:.|.:|..|:.|.:..|||.||:.:.|....:.:|:::   .||..:.||:..:| 
 Worm   183 RQVFRIKKAYIRKLLLMDISWLESRQSGHVAAMLQESADSIYNGISDHLPMVVFILSYLLVNIG- 246

  Fly   236 LVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFE 300
             |..::: |.::|....::||..|:..|.:...:...::|..:......:.....:.|.||.:|.
 Worm   247 -VCLYIQ-WDVTLFMCLAIPLLIISRILYSKWFANTMEEETKLQNKITNLVNETFNCITTVISFA 309

  Fly   301 GEAKEVAAYKERVVAAKILNIKRNMFSGIGFG-----LLWFFIYASYALAFWYGVGLVIKGYHEP 360
            .:.:::..: |::.|......:..:.|.:.|.     ||...|:..   |..||:..|       
 Worm   310 AQKQKINKF-EKLSAEHSKLTEERLRSSVVFDSLTQILLTELIFTG---ALCYGIWRV------- 363

  Fly   361 AYENYDAGTMITVFFSVM---MGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEI-------- 414
              .:...|.:..:..:::   :.|::||.   ::.....||....::..::.:.|:|        
 Worm   364 --ADNSPGRLCALAINMLYMCVTSISIGF---HMNGATRAKDNAKEICEVLNEQPKIEVELASID 423

  Fly   415 NPID-----------------GEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTV 462
            |.||                 |:|        .:.|:::.|.||:|.|..:|..::.|:..|:.:
 Worm   424 NNIDYVPVTRCKYRRQSMKFMGKG--------ALHFRDIHFSYPSRKETEVLRGISFKVEAGEKI 480

  Fly   463 ALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENI 527
            |:||.||.||||...|:.|||||..|.:|.:|.|:|.:..:.||.:..:|.|||:||..:|.:||
 Worm   481 AIVGSSGSGKSTLTALLLRFYDPTKGAILLDGENIKTMCPDDLRGQCSLVSQEPVLFDGTISDNI 545

  Fly   528 RYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILL 592
            ||||.|||::||..||....|..||..||.|..|.|||||.|||||||||:|||||:||.|.:|:
 Worm   546 RYGRLDATQQEINDAARKVGAWKFINSLPDGMQTRVGERGHQLSGGQKQRVAIARAVIRKPIVLI 610

  Fly   593 LDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELME- 656
            .||||||||...|.:|.||::..|.|.|||.:||||||::.:|||:|:::|::||.|...||:. 
 Worm   611 FDEATSALDNIHEEEVNAAIDLASEGLTTITIAHRLSTIKNSDRIIVLHEGKIVEEGVPDELIAD 675

  Fly   657 --------LKDHYFNLVTTQ-------------------------LGEDD------GSVLSPTGD 682
                    ..|...:.:|.|                         :..|.      .|.|.....
 Worm   676 ANGIFHKMYNDQRLDQLTQQHQQLHQQQAKPPSLQQQMSFSPPPNMDPDQQRRAWARSSLGGNKK 740

  Fly   683 IYKNFDIKDEDEEEIK--VLSEDEDEDVMVTDEKNKKKKKKKVKDPNE----------------- 728
            :.|::.:...::|::|  |:|:.:.|.:   |.|..|.....||...:                 
 Worm   741 LGKSYSVNSMEKEKLKLPVMSKKKSERL---DYKYSKVHSMDVKQHTDSMHDDDDLPGKETNFTV 802

  Fly   729 VKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLF----GSILQILSVKDNDQYVRENSNQ 789
            :|.::...:...|    :..|.|.:.|:   ..:|.:|.    .|:|:|....|.::.::     
 Worm   803 LKDLIYSYRTGLP----LLAGAIPTTIV---RAVFYLLICFQVASVLEISIAPDEERALQ----- 855

  Fly   790 YSLYFLIAGIVVGIATFLQIY------FFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGS 848
               .|::|.|...:.....|:      |..:.|....:.:|..||..:||...|:||::.|..|.
 Worm   856 ---IFIVAAIYTALIIVKTIFEALGRIFIALYGHGFCKFMRNEMFRKVLRHGAAYFDEERNSPGR 917

  Fly   849 LCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTL 913
            |..::..:::.:.....|::..::..:......|..:::..|.:.|:.    .|...|:::.|.|
 Worm   918 LVHKVINESSTLNEIMEQKLDMLIPGVVCSLFSIVCALWINWKMALLC----SFQFPAYFVIRIL 978

  Fly   914 MAKENMGSAKTM----ENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRG 974
            ..:|.....:.|    :....||..|::|:.|:.:...:..|:..:...|.|..:..::.:....
 Worm   979 QIREGTKRQRQMVDEEKKAANLASVVLANMSTIKAYNLQSHFYNVFCDALKPVSQCMQKQSLISA 1043

  Fly   975 LVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSA 1039
            ||:....|..:...|..:::|...::...|...|..:|......|....:..:|...:..|...|
 Worm  1044 LVFACQYSFTYILIAITLHFGKVMMLANEISVFDYMRVVLLTQFGANFFSQLIASVSDFTKAQIA 1108

  Fly  1040 AKTIFTFLRRQPSIVDRPGVSRDPWHS--EGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIA 1102
            |:.:...:|..|  ||...:|.:....  ||.:....|.|.||:|..:.||..|.|.|..|:.||
 Worm  1109 AENVMRVIREPP--VDMDNLSEEGLRPKLEGNLCLKDVSFRYPSRPIVPVLTNLNLKVRGGESIA 1171

  Fly  1103 LVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENIS 1167
            ||||||.|||:.|.|.||.|:..:|..:||:.::::::...||..:..|.|||.||..||:|||:
 Worm  1172 LVGPSGSGKSSVISLFQRMYNATDGVVIIDKYNIKSINPAYLRRCIVQVGQEPDLFSFTIKENIA 1236

  Fly  1168 YGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIM 1232
            :|......|..::|.|.|.::||.||.:||.||||.:||.|||||||||||||||||:||.|.::
 Worm  1237 FGMMESEATIDKVIEAAKIADIHNFITSLPQGYDTEVGEFGAQLSGGQKQRIAIARAIIRKPTVL 1301

  Fly  1233 LLDEATSALDAESEKVVQDALDAASEGR----TTISIAHRLSTVVHSDVIFVFENGLVCEAGDHK 1293
            ||||||||||:.||:.||:|.:......    |.|.|||||||:.:.|.|:|..:|.:.|.|.|:
 Worm  1302 LLDEATSALDSASEREVQNAFERVKRSTKTQCTCIQIAHRLSTIRNVDKIYVIVHGEIAEEGSHE 1366

  Fly  1294 QLLANRGLYYTLYKL 1308
            ||:..:|:||.:.::
 Worm  1367 QLINLKGIYYEMNQM 1381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 393/1368 (29%)
ABC_membrane 92..382 CDD:279056 62/315 (20%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 116/245 (47%)
ABC_membrane 750..1020 CDD:279056 51/283 (18%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 116/243 (48%)
pgp-10NP_509205.2 MdlB 73..687 CDD:224055 195/660 (30%)
ABC_membrane 156..381 CDD:294371 44/240 (18%)
ABC_MTABC3_MDL1_MDL2 450..687 CDD:213216 114/236 (48%)
ABC_membrane 823..1099 CDD:294371 52/290 (18%)
MdlB 825..1382 CDD:224055 178/574 (31%)
P-loop_NTPase 1141..1381 CDD:304359 116/239 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
76.880

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