DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and pgp-9

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_507487.1 Gene:pgp-9 / 180165 WormBaseID:WBGene00004003 Length:1294 Species:Caenorhabditis elegans


Alignment Length:1299 Identity:532/1299 - (40%)
Similarity:764/1299 - (58%) Gaps:67/1299 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 KKSKHDESDASDEEDGSQYHEDV---KQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSL 107
            ||.|.|    |..|..|:..|:.   .::|.|||:||.:..||.:..:|::.:.|||:..|..|:
 Worm     5 KKKKDD----SSSEGSSEKKEEAPPPPKISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSI 65

  Fly   108 IFGNLANDMIDLGGLLESGKSYRADDAISTL-LLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYA 171
            |.||::.:.:.||.:.....|..::.|.:.. ...:|.|..|:..|:|..:....:|..:||...
 Worm    66 IMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVI 130

  Fly   172 AHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSL 236
            ........|.:||.|::.|::.|||.|.||.:::::.::|.::.:|..:||.:....:..|:|..
 Worm   131 CEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGF 195

  Fly   237 VLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEG 301
            .:||...|.|:|:.::..|...|....:|...:..|.||...||.|..:||..|:.||||.||.|
 Worm   196 AVAFTYDWLLTLIMMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNG 260

  Fly   302 EAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYD 366
            :..|...|::.:...|...||::...|.|....:..|||||.||||.|...|..|       ..:
 Worm   261 QEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG-------RLE 318

  Fly   367 AGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTI 431
            :||::|||||||||||.:|.|.......|.|.||.|.::.:|::||||:....||:..::....|
 Worm   319 SGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRI 383

  Fly   432 EFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTN 496
            ...:|||.||||.:|.||..::|....||||||||.|||||||.|||:||||:|.||.:|.:...
 Worm   384 SVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 448

  Fly   497 LKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDT 561
            ::|.:|.:||..:|||.|||.||.|||.:||||||.|.:.|:|..|...||||.|||..|:|.:|
 Worm   449 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNT 513

  Fly   562 LVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAH 626
            |||:||.|:||||||||||||||:|:|:||||||||||||..||:.||:|||..|.|||||::||
 Worm   514 LVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAH 578

  Fly   627 RLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKD 691
            ||||||.||:|:|:..|:|:|.|||:.|:|.|..|..||..|              ::.:.|.|.
 Worm   579 RLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ--------------VFADVDDKP 629

  Fly   692 EDEEEIKVLSED----------EDEDVMVTD-----------EKNKKKKKKKVKDPNEVKP-MLE 734
            :.:|..:.:|..          :.::..|.:           ||..|:.||::::...||. :.:
 Worm   630 KKKEAERRMSRQTSQRKGSVNFKTQESQVDEKPGAPPAPEAAEKEIKRLKKELEEEGAVKANLFK 694

  Fly   735 VMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGI 799
            :::..:|||:.|....|:::|.|..||.|::.|..|:.:.|..|.|| ::::.:.::|.||:...
 Worm   695 ILRYARPEWIYIFFAIIAALIQGAVMPAFSLFFSQIINVFSNPDRDQ-MKKDGHFWALMFLVLAA 758

  Fly   800 VVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGAT 864
            |.|.:...|...||:|.||||.|:|..::..:|||:..:||...:..|.:..||:.||..::.|.
 Worm   759 VQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAI 823

  Fly   865 GQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGS----AKTM 925
            ..|:|:|..:|:::..|:.::.||.|.:..:.:|..||:.:.    :.||.|.:.||    ||.|
 Worm   824 DYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG----QALMMKYHGGSATSDAKEM 884

  Fly   926 ENCTKLAVEVVSNIRTVASLGREEMFHQNYIGML-IP-AVEISKRNTHFRGLVYGLARSLMFFAY 988
            ||..|.|:|.:.|||||.:|..:...:..:...| .| ...|||  ...|||.||.|.|:.||.|
 Worm   885 ENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK--AIIRGLTYGFANSIQFFTY 947

  Fly   989 AACMYYGTWCVIHRGILF--GDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQP 1051
            ||...:|.:.:..:.:|.  .:|.:|..|:.....:|..|.::.|...|...||..||..|..:|
 Worm   948 AAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEP 1012

  Fly  1052 SIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQ 1116
            .|.........|..| |.|:.:||.|.||.|..:.:|:||.:.|..||.:||||||||||||.|.
 Worm  1013 RIDGMTSSGTYPQLS-GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVIS 1076

  Fly  1117 LIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEII 1181
            |::|.||..|||..:|..|:|.::..:||..:.:|||||||||.:|||||.||......|.::|.
 Worm  1077 LLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIE 1141

  Fly  1182 SACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESE 1246
            :||.|:|||:||..||.||:||:||||.||||||||||||||||||||||:||||||||||.|||
 Worm  1142 TACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 1206

  Fly  1247 KVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQS 1310
            |.||.|||||::.||.|.:||||||:|::..|.|.:||.|.|.|.|.:|:|.||.|:.|.:.||
 Worm  1207 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 1270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 522/1269 (41%)
ABC_membrane 92..382 CDD:279056 91/290 (31%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 144/236 (61%)
ABC_membrane 750..1020 CDD:279056 90/277 (32%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 141/238 (59%)
pgp-9NP_507487.1 PTZ00265 28..1262 CDD:240339 520/1262 (41%)
ABC_membrane 50..334 CDD:279056 91/290 (31%)
ABC_MTABC3_MDL1_MDL2 383..620 CDD:213216 144/236 (61%)
ABC_membrane 710..977 CDD:279056 89/273 (33%)
ABC_MTABC3_MDL1_MDL2 1030..1269 CDD:213216 141/238 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 191 1.000 Domainoid score I1904
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55496
Inparanoid 1 1.050 925 1.000 Inparanoid score I179
Isobase 1 0.950 - 0 Normalized mean entropy S1571
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm4744
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.720

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