DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr50 and haf-1

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_503098.2	Gene:	haf-1 / 178522	WormBaseID:	WBGene00001811	Length:	677	Species:	Caenorhabditis elegans

Alignment Length:	673	Identity:	194/673 - (28%)
Similarity:	331/673 - (49%)	Gaps:	100/673 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DVKQVSYFQLFRYATKKDRA-LYVIG-----------LLSAVATGLTTPANSLIFGNLANDMIDL 119
            |.:..:|  |.|:.|.||.. ||.|.           ....|::|:     .||...:...:||
Worm    55 DRRNAAY--LLRHTTWKDLVELYEIAKPFRKWIFLGTSFMVVSSGI-----FLIIPRILGKLID- 111

  Fly   120 GGLLESGKSYRADDAISTLLLDKVRQFSLQ-NTYIGIIML--VCSYLSITCFNYAAHSQILTIRS 181
              ..:|....:..:.:.|:.:.|  .|..| .:.:|::.:  :.:...:.|...|..:.:.::|.
Worm   112 --QFDSNTGVQKAEEVFTMKIAK--YFKEQPMSLVGLLAIGALATAAKVYCLQIAGVNIVGSLRK 172

  Fly   182 KFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQL 246
            ..:.||:.|||.::|.|..||:.||...|...:...::..:...|..::..|||:.:..:...:|
Worm   173 MVYSSIIRQDMTFFDKNMVGEIGSRHAADTVIVGYSVSSSLRAGVRAVLVGVGSIGMMLMTSLEL 237

  Fly   247 SLVCLTSLPLTFIAMGLVAV-------ATSRLAKKEVTMYAGAAVVAEGA---LSGIRTVKAFEG 301
            |.|...:.|   |.||:..:       .|.:|  :||     ||.|.:.|   ::.::|::....
Worm   238 STVSFLTAP---IVMGIFKMFGRVQQQCTWQL--QEV-----AADVNQTAIERMANMKTIRMLSA 292

  Fly   302 EAKEVAAYKERVVAAKILNIKRN--MFSGIGFGLLWFFIYASYALAFWYGVGLVIKG---YHEPA 361
            |.:.:..|.::  ...:|:|.:.  :..|...|...|..|::::...:||..|:..|   |.|.:
Worm   293 EQQSIDEYCKK--GELVLDISKTEALAKGSLIGSFQFTGYSAFSSILFYGSHLINTGHITYGELS 355

  Fly   362 ----YENYDAGTM--ITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGE 420
                |....|.::  |:.|::.:|..:                ||.:::..:....|.:|.  ..
Worm   356 SFCLYAVLAAASLSNISGFYNEVMKGL----------------GASSRLLELKNAQPIMNL--NS 402

  Fly   421 GKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDP 485
            |.|..:..|:|:|:.|.|.|..|.:.  |..::..|.||:..|::||||.|||:...|:.|.|||
Worm   403 GIKKTDITTSIQFENVSFAYAGRKKT--LENISFDIPRGKITAVIGPSGSGKSSIANLMLRLYDP 465

  Fly   486 QAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGR---EDATREEIEAAAAAAN 547
            ..|.:..:|.:|:||:....|..||.|||||:||..||.|||..|.   |..::.|:|.||..||
Worm   466 ADGRVTVDGVDLRDLNATTWRHAIGTVGQEPVLFTCSIRENILMGTEHPEKVSQYELEEAAQLAN 530

  Fly   548 AAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAAL 612
            |..||:....|::|:|||.|.:||||||||||||||||..|:|::|||||||||..|:..::..|
Worm   531 ALDFIQGFENGFETMVGEHGCKLSGGQKQRIAIARALISKPKIMILDEATSALDATSDYLIRMTL 595

  Fly   613 EKV--SAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQ------- 668
            :.:  :...|.:::||||:|:::||::|.:|:|.:...||..|:|:::    |.:..|
Worm   596 DNLLKNHNLTVLVIAHRLATMQQADQVVYVNRGRIEGQGTFDEMMKIQ----NSIVEQEARRRGI 656

  Fly   669 -LGEDDGSVLSPTGDIYKNFDIK 690
             :.|....|.:|   :.:.|.:|
Worm   657 PMNEQMSRVNTP---VARGFSLK 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	193/671 (29%)
		ABC_membrane	92..382	CDD:279056	66/313 (21%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	105/241 (44%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
haf-1	NP_503098.2	MdlB	82..641	CDD:224055	176/600 (29%)
		ABC_membrane	93..363	CDD:294371	62/291 (21%)
		P-loop_NTPase	413..641	CDD:304359	103/229 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810