DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and pgp-1

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_502413.1 Gene:pgp-1 / 178215 WormBaseID:WBGene00003995 Length:1321 Species:Caenorhabditis elegans


Alignment Length:1313 Identity:507/1313 - (38%)
Similarity:753/1313 - (57%) Gaps:72/1313 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 KSKKKSKHDESDASDE----EDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTP 103
            |:.:..:.|..|::.|    .|..:  |.|.:||..||:||.|..::.|..||.|.||.||...|
 Worm    30 KTVEDYEGDNIDSNGEIKITRDAKE--EVVNKVSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLP 92

  Fly   104 ANSLIFGNLA----NDMIDLGG----LLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVC 160
            ..|::.|.::    |:.|.:..    .|.:|::|...| ....:::.|..::...  :|  |...
 Worm    93 LMSILQGKVSQAFINEQIVINNNGSTFLPTGQNYTKTD-FEHDVMNVVWSYAAMT--VG--MWAA 152

  Fly   161 SYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMF 225
            ..:::||:.|.|......:|.:|.:|||.|::.|:|.|.||.:|:::.::|.::::|..:|:.|.
 Worm   153 GQITVTCYLYVAEQMNNRLRREFVKSILRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMA 217

  Fly   226 VHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGAL 290
            ..||..|:...::||...|||:||.|...|:..:....:|.:.|..|.:|...||.|..|.|..:
 Worm   218 FQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETI 282

  Fly   291 SGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIK 355
            |.||||.:..|...|:..|...|..||...:.:.:|.||.||.:....:.|:||||:.|||.|..
 Worm   283 SSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHD 347

  Fly   356 GYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGE 420
            |       :.:.|.|:|.|.|||||||.:|:|.|.:...|.|:||.:.::.::::.|.|:.....
 Worm   348 G-------SLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKA 405

  Fly   421 GKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDP 485
            |:|..:....|..:.|.|.||:||:|.||..:||:::.||||||||.|||||||.|.|:.|:||.
 Worm   406 GRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDV 470

  Fly   486 QAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAI 550
            ..|.:..:|.:::|:::.:||..:.||.|||.||..:|.|||..|:|..||||:.||...|||..
 Worm   471 LKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEK 535

  Fly   551 FIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKV 615
            |||.||.||:||||:||.||||||||||||||||:|:|:||||||||||||..||..||.||:|.
 Worm   536 FIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKA 600

  Fly   616 SAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPT 680
            :.||||||:||||||:|.||.|:....|:|||.|.|:.||..:..|::|||.|...|.....:..
 Worm   601 AKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAVDSAAEG 665

  Fly   681 GDIYKNFDIKDEDEEEIKVLSEDEDEDVM---------------VTDEKNKK-------KKKKKV 723
            ....:|...:...|.|.......|.:|:|               |.|||.::       :.|:::
 Worm   666 KFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDALSRLKQEL 730

  Fly   724 KDPNEVKP-MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENS 787
            ::.|..|. :.|::...:|..|.:.:|..::.|.|...|.::|.|.|.:.:.:  .|........
 Worm   731 EENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVFA--GNPADFLSQG 793

  Fly   788 NQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCAR 852
            :.::|.||:.....||.:||..:|.|||.|.||..||..:|..:|.|.:.:||...|.:|.:..|
 Worm   794 HFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTR 858

  Fly   853 LSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKE 917
            |:.|...::.|...|..|::.::.::..||.|:.:|.|.:.|:.:|..|.:....|::......:
 Worm   859 LATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGK 923

  Fly   918 NMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGML-IPAVEISKRNTHFRGLVYGLAR 981
            |:.||....:..|:|:|.:.|:|||.:|.||:.|::|:...| ||..|..| ....:||.||.|.
 Worm   924 NVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIK-EAFIQGLSYGCAS 987

  Fly   982 SLMFFAYAACMYYGTWCVIHRG--ILFGD--------VFKVSQALIMGTASIANALAFAPNMQKG 1036
            |:        :|....|....|  ::..|        |.:|..|:.:.|:::..|.::.|...|.
 Worm   988 SV--------LYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKA 1044

  Fly  1037 VSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKI 1101
            ..|...||..||: .|.:|...::.:.....|.|.|..|:|:||.|.||::||||..:|..||.:
 Worm  1045 TFAGGIIFGMLRK-ISKIDSLSLAGEKKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTL 1108

  Fly  1102 ALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENI 1166
            ||||||||||||.:.|::||||...|...||..:::.::..:.|:|:.||||||.|||.:|.|||
 Worm  1109 ALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENI 1173

  Fly  1167 SYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKI 1231
            .||.:..:||..::..|.:.:|||.|||.||.|::||:|::|.||||||||||||||||:|||||
 Worm  1174 IYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKI 1238

  Fly  1232 MLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLL 1296
            :||||||||||.|||||||:|||.|.||||.|.|||||:||:::|.|.|..||.:.|.|.|.||:
 Worm  1239 LLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLM 1303

  Fly  1297 ANRGLYYTLYKLQ 1309
            :.:|.||.|.:.|
 Worm  1304 SEKGAYYKLTQKQ 1316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 499/1280 (39%)
ABC_membrane 92..382 CDD:279056 93/297 (31%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 137/236 (58%)
ABC_membrane 750..1020 CDD:279056 78/280 (28%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 137/238 (58%)
pgp-1NP_502413.1 PTZ00265 38..1311 CDD:240339 503/1298 (39%)
ABC_membrane 81..367 CDD:279056 93/297 (31%)
ABC_MTABC3_MDL1_MDL2 416..653 CDD:213216 137/236 (58%)
ABC_membrane 760..1028 CDD:279056 78/278 (28%)
ABC_MTABC3_MDL1_MDL2 1077..1316 CDD:213216 137/238 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 191 1.000 Domainoid score I1904
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55496
Inparanoid 1 1.050 925 1.000 Inparanoid score I179
Isobase 1 0.950 - 0 Normalized mean entropy S1571
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm4744
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.690

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