Protein Alignment Mdr50 and pgp-2

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001300410.1
• Gene: pgp-2 / 172262
• WormBaseID: WBGene00003996
• Length: 1296
• Species: Caenorhabditis elegans
• Alignment Length: 1326
• Identity: 490/1326 - (36%)
• Similarity: 751/1326 - (56%)
• Gaps: 77/1326 - (5%)

  Fly    25 LGAKLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYV 89
            :|...|.:....||.:..:|:.......||:|.:|      ..||..:| .:|.|....|..|.:
 Worm     1 MGKDTEKTPLLLKSLDKQRSQTSLSSHSSDSSIDE------STVKLTNY-GIFYYTQGVDLLLLI 58

  Fly    90 IGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRAD----------DAISTLLLD--- 141
            .|.::||..|...|..:::.|.:....:         ::..:|          :.:..:.||
 Worm    59 TGTVAAVIHGAGFPLLAIVLGGMTTVFL---------RAQNSDFVVGVDNVNPEGLVPISLDEFN 114

  Fly   142 -KVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVAS 205
             :|.::.:....:|::|...||:.|.||...|...:..:|..:.::||.|.::|:|..|:|.:.:
 Worm   115 SEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFDKQQTGNLTA 179

  Fly   206 RMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSR 270
            |:.:||.::.:||.:|..:.|....||:....:.|...|.::||.:...||..::...::.:.:.
 Worm   180 RLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMAT 244

  Fly   271 LAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLW 335
            ..:.|...||.|..:||...|.||||.:..|..:|:..:...:...:...|.:..:.|||.|...
 Worm   245 RTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEVGRQTGIVKYCYMGIGVGFSN 309

  Fly   336 FFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGA 400
            ..:|:|||||||||..|:|   ::|   .:|.|.:.||||:|:.||.::|.|.|::.:||.|:||
 Worm   310 LCMYSSYALAFWYGSTLII---NDP---TFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTARGA 368

  Fly   401 CAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALV 465
            .:.|..:|...|:|:|...||..::.....|.||:|.|:||:|.::.:|..::|::..|..:|||
 Worm   369 ASTVLRVINSHPKIDPYSLEGILVDNMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALV 433

  Fly   466 GPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYG 530
            |.|||||||.:.|:||||||..|.:|.:|.:|::::::.||.:||:|.|||:||..:|||||:.|
 Worm   434 GSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMG 498

  Fly   531 REDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDE 595
            .|.||.:::..|...|||..|||:||.||.|.|||:|.||||||||||||||||:::|:||||||
 Worm   499 NEHATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDE 563

  Fly   596 ATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDH 660
            |||||||.:|.:||.||::..||||||||||||||:|..|||.|...|.:||||:|:|||..:..
 Worm   564 ATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGI 628

  Fly   661 YFNLVTTQL--------GEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDED--EDVMVTDEKN 715
            ::::...|:        |:|....:|.:.  :.:...|......|.:.:....  |:|.:.|..|
 Worm   629 FYDMTQAQVVRQQQQEAGKDIEDTISESA--HSHLSRKSSTRSAISIATSIHQLAEEVELIDPFN 691

  Fly   716 KKKKKKKVKD------PNEVK----PMLEVMKMN--KPEWLQIAVGCISSVIMGCAMPIFAVLFG 768
            .:..:..::.      ..|.|    .|.::.|.|  |..|  ...|...:.|.|...|:||:::.
 Worm   692 GQTNQDVIRSRILSAFGGECKAPPTSMFKIFKFNGDKVGW--FIGGIFGAFIFGSVTPVFALVYA 754

  Fly   769 SILQILSVKDNDQYVRENSNQYSLY-----FLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMF 828
            .|..:.|:..:..       |.::|     |::.||...:..|......|..||.||.:||...|
 Worm   755 EIFNVYSLPADQM-------QANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAF 812

  Fly   829 EAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLG 893
            :.:|||::|::||..:|||.||.|.:.||..|: ....|:..::.||.|:...:.:..||.|.|.
 Worm   813 KNLLRQDIAFYDDLRHGTGKLCTRFATDAPNVR-YVFTRLPVVLASIVTICGALGIGFYYGWQLA 876

  Fly   894 LVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGM 958
            |:.:...|.:::..|.:..:...:.:...:.:|...|:|.:.|.:||||.||.|:|.||..|...
 Worm   877 LILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEY 941

  Fly   959 LIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASI 1023
            |......:.::.|..|.|:..::||:||.|||..|.|:..|..:.:...||::|..|:......|
 Worm   942 LREPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMI 1006

  Fly  1024 ANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVL 1088
            .|..:|.|::.|...||..:| :|...|:.:|....|.......|.:....|.|:||||.:.:||
 Worm  1007 GNTTSFIPDVVKARLAASLLF-YLIEHPTPIDSLSDSGIVKPITGNISIRNVFFNYPTRKDTKVL 1070

  Fly  1089 KGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQ 1153
            :|..|.:..|:.:||||.|||||||.:.|::|||:.|:|..:||..::||:::::||.|:.||||
 Worm  1071 QGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISSLREQVCIVSQ 1135

  Fly  1154 EPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQR 1218
            ||.|||.||.|||.||.| ||||.|||:.|.|.:|||.||..||.||||.:||||.|||||||||
 Worm  1136 EPTLFDCTIGENICYGTN-RNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLSGGQKQR 1199

  Fly  1219 IAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFEN 1283
            |||||||:|:|.::||||||||||.||||:||:|||||.:|||.:.|||||||:.:||||.:...
 Worm  1200 IAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDVIAIVSE 1264

  Fly  1284 GLVCEAGDHKQLLANRGLYYTLYKLQ 1309
            |.:.|.|.|.:|:....:|....:.|
 Worm  1265 GKIVEKGTHDELIRKSEIYQKFCETQ 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	479/1279 (37%)
pgp-2	NP_001300410.1	PTZ00265	56..1286	CDD:240339	474/1258 (38%)
		MdlB	56..632	CDD:440747	228/590 (39%)