Protein Alignment Mdr50 and haf-4

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001021666.1
• Gene: haf-4 / 171639
• WormBaseID: WBGene00001814
• Length: 787
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 214/562 - (38%)
• Similarity: 306/562 - (54%)
• Gaps: 41/562 - (7%)

  Fly   129 YRADDAISTLLLDKVRQFSLQN-----TYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSIL 188
            |.....|:|::..|... :|.|     |.|.::..|.:......|.||.......||...|..::
 Worm   201 YYTGQVIATVVATKSYP-ALSNAVYIMTIISLVSAVAAGFRGGSFEYAYARIQRAIRYDLFHGLV 264

  Fly   189 HQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTS 253
            .||:.:||.:::|||.||:..|...|.|.:|..|.:|:...|..:||::......|:||||....
 Worm   265 KQDVAFYDAHKTGEVTSRLAADCQTMSDTVALNVNVFLRNCVMLLGSMIFMMKLSWRLSLVTFIL 329

  Fly   254 LPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKI 318
            :|:.|:|..:.......|:::.....|.:..|||..||.:|||::|..|..|...:..::  ...
 Worm   330 VPIIFVASKIFGTYYDLLSERTQDTIAESNDVAEEVLSTMRTVRSFSCENVEADRFYGKL--THT 392

  Fly   319 LNIKRNMFSGIGF-GLLWF------FIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVF-- 374
            |::.|.  ..|.: |.||.      ||..|   ..|||..||:....:        |.::..|
 Worm   393 LDVTRT--KAIAYIGFLWVSELFQSFIIVS---VLWYGGHLVLTQKMK--------GDLLVSFLL 444

  Fly   375 FSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLT-TIEFKEVEF 438
            :.:.:|. |:............:.||..|||..|::.|:   |...|:.:.|.:. .|||:.|.|
 Worm   445 YQMQLGD-NLRQMGEVWTGLMQSVGASRKVFEYIDREPQ---IQHNGEYMPENVVGKIEFRNVHF 505

  Fly   439 QYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDIN 503
            .||||.:..||..|:..:..|:|||||||||.|||:||.|::.||.|.||.:|.:|..|::.:.:
 Worm   506 SYPTRSDQPILKDLSFTVEPGETVALVGPSGSGKSSCISLLENFYVPNAGQVLVDGVPLEEFEHH 570

  Fly   504 WLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGA 568
            ::..:|.:|||||:|||.|:.||:|||.|.|..|.|. :...|||..||.:....|:|.|||:|.
 Worm   571 YIHKKIALVGQEPVLFARSVMENVRYGVEVADTEIIR-SCEMANAHGFIMQTTLKYETNVGEKGT 634

  Fly   569 QLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRR 633
            |:||||||||||||||:|:|.|||||||||||||.||..||.|:.|...|::.|::|||||||.:
 Worm   635 QMSGGQKQRIAIARALVREPAILLLDEATSALDTESEHLVQEAIYKNLDGKSVILIAHRLSTVEK 699

  Fly   634 ADRIVVINKGEVVESGTHQELMELKD---HYFNLVTTQLGED 672
            ||:|||||||.|.:.|.|:.|  |||   .|..||..|:..|
 Worm   700 ADKIVVINKGRVEQIGNHETL--LKDTNGTYAKLVQRQMMGD 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	214/562 (38%)
		ABC_membrane	92..382	CDD:279056	71/266 (27%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	130/239 (54%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
haf-4	NP_001021666.1	3a01208	16..732	CDD:273363	210/553 (38%)
		ABC_membrane	189..449	CDD:279056	70/263 (27%)
		ABC_MTABC3_MDL1_MDL2	498..735	CDD:213216	130/239 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910