DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and Abcc4

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:XP_038948894.1 Gene:Abcc4 / 170924 RGDID:620266 Length:1382 Species:Rattus norvegicus


Alignment Length:1483 Identity:343/1483 - (23%)
Similarity:581/1483 - (39%) Gaps:411/1483 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 KKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKD---------------RALYVIGLLS 94
            |::.:.|:..:...||.|::..:..| .|:.......|||               ::..::|:.:
  Rat    36 KRRLEEDDMFSVLPEDRSKHLGEELQ-GYWDKEVLRAKKDARKPSLTKAIVKCYWKSYLILGIFT 99

  Fly    95 AVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADD--AISTLLLDKVRQFSLQNTYIGIIM 157
            .:..  ||.....||         ||.:::..:.|.:||  |:.|..           .|..::.
  Rat   100 LIEE--TTRVVQPIF---------LGKIIDYFEKYDSDDSAALHTAY-----------GYAAVLS 142

  Fly   158 LVCSYLSITCFNYAAHSQILTIRSK------FFRSILHQDMKWYDFNQSGEVASRMNEDLSKMED 216
            |....|:|....|..|.|...:|.:      .:|..|...........:|::.:.::.|::|.  
  Rat   143 LCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKF-- 205

  Fly   217 GLAEKVVMFVHYLVA----FVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGL---VAVATSRLAKK 274
               ::|.:|:|:|.|    .:|..:|.:|   ::.:.||..|.:..|.:.|   :....|.|..|
  Rat   206 ---DQVTIFLHFLWAGPLQAIGVTILLWV---EIGISCLAGLAILVILLPLQSCIGKLFSSLRSK 264

  Fly   275 EVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGI-------GFG 332
            ...............::|:|.:|.:..         |:..|..|.|:::...|.|       |..
  Rat   265 TAAFTDARIRTMNEVITGMRIIKMYAW---------EKSFADLITNLRKKEISKILGSSYLRGMN 320

  Fly   333 LLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTM-------ITVFFSVMMGSMNIGMAAPY 390
            :..||| |:..:.|......|:.|....|...:.|.|:       :|:||...:..::       
  Rat   321 MASFFI-ANKVILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVS------- 377

  Fly   391 IEAFGIAKGACAKVFHIIEQIPE---INPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKL 452
             ||  :......|.|.:::::||   ..|.||:.....:..|.  |.:.....||      |..|
  Rat   378 -EA--VVSVRRIKNFLLLDELPERKAQEPSDGKAIVHVQDFTA--FWDKALDTPT------LQGL 431

  Fly   453 NLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPI 517
            :.....|:.:|:|||.|.|||:.:..|.....|.:|.:..:|             ||..|.|:|.
  Rat   432 SFTARPGELLAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHG-------------RIAYVSQQPW 483

  Fly   518 LFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIAR 582
            :|:.::..||.:||: ..:|..|....|......::.|..|..|::|:|||.||||||.|:.:||
  Rat   484 VFSGTVRSNILFGRK-YEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLAR 547

  Fly   583 ALIRDPEILLLDEATSALDTASEAK-------VQAALEKVSAGRTTIIVAHRLSTVRRADRIVVI 640
            |:.:|.:|.|||:..||:| |...|       .|...||:     ||:|.|:|..::.|..|:::
  Rat   548 AVYQDADIYLLDDPLSAVD-AEVGKHLFQLCICQTLHEKI-----TILVTHQLQYLKAASHILIL 606

  Fly   641 NKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDED 705
            ..||:|:.||:.|.:            :.|.|.||:|            |.|:||.       |.
  Rat   607 KDGEMVQKGTYTEFL------------KSGVDFGSLL------------KKENEEA-------EP 640

  Fly   706 EDVMVTDE-KNKKKKKKKVKDPNEVKPML----------EVMKMNKPE----------------- 742
            ..|..|.. :|:...:..:......:|.|          |..:..:||                 
  Rat   641 SPVPGTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQDAENTQAAQPEESRSEGRIGFKAYKNYF 705

  Fly   743 -----WLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKD--------------NDQYVRENSN 788
                 |..|               ||.||...:.|:..|..              ||   .:|:|
  Rat   706 SAGASWFFI---------------IFLVLLNLMGQVFYVLQDWWLSHWANRQGALND---TKNAN 752

  Fly   789 QYSLYFLIAGIVVG---IATFLQIY--------FFGIAGERL--------TERLRGLMFEAMLRQ 834
                     |.|.|   ::.:|.||        .||||...|        ::.|...|||::|:.
  Rat   753 ---------GNVTGTLDLSWYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRMFESILKA 808

  Fly   835 EVAWFDDK------------ANG----------------TGSLCARLSGDAAAVQGATG------ 865
            .|.:||..            .:|                .|||       .|:|...||      
  Rat   809 PVLFFDRNPIELTQLEVFRVVDGALDSHRHLSHPHPWPQNGSL-------QASVTSVTGSDVIRF 866

  Fly   866 -----------------QRIG--------TIVQSISTLALGIALSMYYEWSLGLVALAFTPFIL- 904
                             :.||        |.:..|.||.|.:        |:..||.|..|:|| 
  Rat   867 PEVLLLALPGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVV--------SVIAVAAAVIPWILI 923

  Fly   905 ------IAFYMQRTLMAKENMGSAKTMENCTKLAV-----EVVSNIRTVASLGREEMFHQNYIGM 958
                  |.|.:.|.... |.....|.:|:.|:..|     ..:..:.|:.:...||...:.:   
  Rat   924 PLVPLSIIFVVLRRYFL-ETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELF--- 984

  Fly   959 LIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFG--------DVFKVSQA 1015
                  .:.::.|.......|..| .:||.........:.::   :.||        |..:|..|
  Rat   985 ------DAHQDLHSEAWFLFLTTS-RWFAVRLDAICAVFVIV---VAFGSLVLAKTLDAGQVGLA 1039

  Fly  1016 L-----IMG--------TASIANALAFAPNMQKGVSAAKTI-FTFL--------RRQPSIVDRPG 1058
            |     :||        :|.:.|.:         :|..:.| :|.|        |::|.    ||
  Rat  1040 LSYSLTLMGMFQWSVRQSAEVENMM---------ISVERVIEYTDLEKEAPWECRKRPP----PG 1091

  Fly  1059 VSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYD 1123
                 |..||.:.||.|.|:|.....: |||.|...:...:|:.:||.:|.|||:.|..:.|..:
  Rat  1092 -----WPHEGVIVFDNVNFTYSLDGPL-VLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSE 1150

  Fly  1124 VDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSN 1188
             .||...||:.....:.:.:||.::.|:.|||:||..|:|:|:   |.....:|:|:..|.::..
  Rat  1151 -PEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHSDEELWKALEEVQ 1211

  Fly  1189 IHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDAL 1253
            :.|.|.:||...||.:.|.|:..|.||:|.:.:|||:::..:|:::||||:.:|..:::::|..:
  Rat  1212 LKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDELIQQKI 1276

  Fly  1254 DAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLAN-RGLYYTL 1305
            .......|.::|||||:|::.||.|.|.::|.:.|..:...||.| ..|:|.:
  Rat  1277 REKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYVLLQNPESLFYKM 1329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 338/1459 (23%)
ABC_membrane 92..382 CDD:279056 63/318 (20%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 74/243 (30%)
ABC_membrane 750..1020 CDD:279056 75/394 (19%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 77/237 (32%)
Abcc4XP_038948894.1 MRP_assoc_pro 6..1334 CDD:188098 343/1483 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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