Protein Alignment Mdr50 and LOC116406449

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: XP_002933334.2
• Gene: LOC116406449 / 116406449
• XenbaseID: XB-GENE-29091411
• Length: 1265
• Species: Xenopus tropicalis
• Alignment Length: 1298
• Identity: 550/1298 - (42%)
• Similarity: 776/1298 - (59%)
• Gaps: 66/1298 - (5%)

  Fly    31 DSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSA 95
            |:..|:...|.....:|||               .|.:..|...|:||:|...|..|.:.|.|.|
 Frog    14 DTLLDKAQEETTNVNEKSK---------------QEQIIPVGPIQIFRFAGWLDIFLMIFGTLGA 63

  Fly    96 VATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVC 160
            :..|...|..:::||.:||..:.....|::.........|.    ::::.|||....:|...|||
 Frog    64 MGCGSCFPLMNVVFGEMANSFLCHNSSLQNSSLCAEFKPIE----EQIQLFSLYYAGLGFGALVC 124

  Fly   161 SYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMF 225
            .||.::.:...|..|...:|..||.|:|.|::.|:|..:||::.:|:.||::|:.:|:.:||..|
 Frog   125 GYLQVSFWVLTASRQTRKMRKAFFHSVLSQEIGWFDVTKSGDLNTRLTEDINKINNGIGDKVGHF 189

  Fly   226 VHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGAL 290
            .......:..:::..:|||:|:||.|.:.|:..:|..:.|...:.|..||:..||.|..||:..|
 Frog   190 FQNSTTCLCGILIGLIKGWKLALVILATSPVLALASAMFARILASLTTKELAAYAKAGAVAQEVL 254

  Fly   291 SGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIK 355
            |.||||.||.|:.||:..|.|.:..||.:.||:.:.|....||::...|::|.|.||||..||:
 Frog   255 SSIRTVVAFGGQEKEIKRYTENMREAKDIGIKKAVASQFSLGLVYGAFYSTYGLGFWYGTTLVL- 318

  Fly   356 GYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGE 420
                 ..:.|..|.::.|||:|.:.|..||.||.:.|||.||:||...:|.:|::...||....|
 Frog   319 -----GDDAYRIGDVLAVFFNVTISSYCIGQAASHFEAFSIARGAAYSIFKVIQKPSFINNFSTE 378

  Fly   421 GKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDP 485
            |.|.:.....||.|.:.|.||:||:|.:||.:||.|..||||||||.|||||||.:||:||.|||
 Frog   379 GFKPDNIKGNIELKNIHFSYPSRPDVKVLNGINLSIKSGQTVALVGQSGCGKSTIVQLLQRLYDP 443

  Fly   486 QAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAI 550
            |.|.|..:|.::|.|::.:.|..||||.|||:||.|:|.:||:|||||.|.||||.|...|||..
 Frog   444 QEGTLAVDGHDIKSLNVRYYRELIGVVSQEPVLFGTTIKQNIKYGREDVTDEEIEKAVKEANAYD 508

  Fly   551 FIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKV 615
            ||..||..|:|||||||||||||||||||:||||:|:|:|||||||||||||.|||.|||||:|.
 Frog   509 FIMALPDKYETLVGERGAQLSGGQKQRIAVARALVRNPKILLLDEATSALDTGSEAIVQAALDKA 573

  Fly   616 SAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLV---TTQLGEDDGSVL 677
            |.|||||:|||||||:..||.|||...|.|.|.|||.||||.:..||:|.   |.||.||.....
 Frog   574 SKGRTTIVVAHRLSTIWTADAIVVFENGAVAEQGTHSELMEKRGIYFSLATAQTVQLSEDKEITE 638

  Fly   678 SPTGDIY---------------KNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKKKKVKDPN 727
            :....|:               ||..:::|||||                     |...|.||..
 Frog   639 TKQNGIHEKTSLIQRFNSQASLKNIQLEEEDEEE---------------------KPDSKEKDLP 682

  Fly   728 EVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSL 792
            .|. .|::||:|:.||..|.:|..::.:.|...|:|::.:..::.:.:..|.:: :|..|..||:
 Frog   683 SVS-FLQLMKLNRSEWPYILLGIFAAGVNGAINPLFSIFYARVIAVFASNDPER-IRHESTIYSI 745

  Fly   793 YFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDA 857
            .|::..:::.||..::.|.||.:||.||.|||.:.|:||::|::||||||.|.||:|..||:.||
 Frog   746 LFVVISVIILIAYTVRGYMFGRSGETLTMRLRHMAFKAMIQQDIAWFDDKDNNTGALTTRLATDA 810

  Fly   858 AAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSA 922
            :.:|.|||.|:|.:.:::..:.|.:.::..|.|.:.|:|:|..||::||..::.|.:|.......
 Frog   811 SEIQTATGSRLGLVAENVVGIILTVVIAFVYGWEMSLLAIAMAPFVVIAGMLEFTAVAGFATRDK 875

  Fly   923 KTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFA 987
            |.::...|:|.|.|.||||:.||.||..|.:.|...|......::|..|..|:.:...:|.|:|.
 Frog   876 KQLQRSGKIATEAVDNIRTLVSLTRERTFEEMYSESLQKPYRNAQRKAHMYGMCFATGQSFMYFI 940

  Fly   988 YAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPS 1052
            :||...:|.:.:....:...:||.|...:..|..::.|.|:|||:..|.:|||:.:|....|:|:
 Frog   941 HAAVFRFGAYLIRVERMNVEEVFLVFSVITFGAMTLGNTLSFAPDYAKAMSAARYLFALFEREPT 1005

  Fly  1053 IVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQL 1117
            |.......:.|.:..|.:.|..|.|:|||||::.||:.|.:.|..||.:|.||.|||||||.:||
 Frog  1006 IDSFSQQGQKPEYFSGSLEFRNVSFNYPTRSDVAVLRDLCIKVESGQTVAFVGSSGCGKSTSVQL 1070

  Fly  1118 IQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIIS 1182
            :|||||..||..|:|:.|.:..::..||:|:|||||||:|||.:|.|||:||||:|.|:..||.|
 Frog  1071 LQRFYDPQEGEMLLDDVDAKCFNVQWLRSQMGIVSQEPVLFDCSIAENIAYGDNSRTVSMDEIQS 1135

  Fly  1183 ACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEK 1247
            |.|.:|||.||..|||.|:|.:|.||.||||||||||||||||||.|||:||||||||||.||||
 Frog  1136 AAKAANIHSFIQGLPLKYETLVGAKGTQLSGGQKQRIAIARALIRAPKILLLDEATSALDNESEK 1200

  Fly  1248 VVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQS 1310
            |||.|||.|.:|||.|.|||||:||.::|:|.|...|.:.|.|.|::||...|.||.|...|:
 Frog  1201 VVQQALDQARKGRTCILIAHRLTTVQNADIIVVMNKGKIIEHGSHQELLGKHGAYYDLVNAQA 1263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	542/1256 (43%)
LOC116406449	XP_002933334.2	PTZ00265	67..1256	CDD:240339	529/1221 (43%)