DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and ABCC4

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_005836.2 Gene:ABCC4 / 10257 HGNCID:55 Length:1325 Species:Homo sapiens


Alignment Length:1331 Identity:303/1331 - (22%)
Similarity:560/1331 - (42%) Gaps:291/1331 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 IDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRS 181
            |.||.::...::|   |.:.::.|:....::...|:..:|:.:..:|      |..|.|...:|.
Human   111 IFLGKIINYFENY---DPMDSVALNTAYAYATVLTFCTLILAILHHL------YFYHVQCAGMRL 166

  Fly   182 K------FFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAF 240
            :      .:|..|...........:|::.:.::.|::|.     ::|.:|:|:|  :.|.|....
Human   167 RVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKF-----DQVTVFLHFL--WAGPLQAIA 224

  Fly   241 VKG--W-QLSLVCLTSLPLTFIAMGLVAV---ATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAF 299
            |..  | ::.:.||..:.:..|.:.|.:.   ..|.|..|..|............::|||.:|.:
Human   225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMY 289

  Fly   300 EGEAKEVAAYKERVVAAKILNIKRNMFSGI-------GFGLLWFF---------IYASYALAFWY 348
            ..         |:..:..|.|:::...|.|       |..|..||         .:.:|.|    
Human   290 AW---------EKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVL---- 341

  Fly   349 GVGLVIKGYHEPAYENYDAGTMITVFFSV-MMGSMNIGMAAPYIEAFGIAKGACAKV-----FHI 407
             :|.||              |...||.:| :.|::.:.:...:..|......|...:     |.:
Human   342 -LGSVI--------------TASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLL 391

  Fly   408 IEQIPEIN-PIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCG 471
            :::|.:.| .:..:|||:........|.:...:.||      |..|:..:..|:.:|:|||.|.|
Human   392 LDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPT------LQGLSFTVRPGELLAVVGPVGAG 450

  Fly   472 KSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATR 536
            ||:.:..|.....|..|.:..:|             ||..|.|:|.:|:.::..||.:|:: ..:
Human   451 KSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKK-YEK 501

  Fly   537 EEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALD 601
            |..|....|......::.|..|..|::|:||..||||||.|:.:|||:.:|.:|.|||:..||:|
Human   502 ERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD 566

  Fly   602 T-ASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLV 665
            . .|....:..:.::...:.||:|.|:|..::.|.:|:::..|::|:.||:.|.:          
Human   567 AEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFL---------- 621

  Fly   666 TTQLGEDDGSVLSPTGDIYKNFDIKDEDEEE-----------------------------IK--V 699
              :.|.|.||:|.           ||.:|.|                             :|  .
Human   622 --KSGIDFGSLLK-----------KDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGA 673

  Fly   700 LSEDEDEDVMVT-DEKNKKKKKKKVKDPNEVKPMLEVMK---MNKPEWLQIAVGCISSVIMGCAM 760
            |...:.|:|.|| .|:|:          :|.|...:..|   .....|:..              
Human   674 LESQDTENVPVTLSEENR----------SEGKVGFQAYKNYFRAGAHWIVF-------------- 714

  Fly   761 PIFAVLFGSILQILSVKDNDQYVRENSNQYSL------------------YFL-------IAGIV 800
             ||.:|..:..|:..|. .|.::...:|:.|:                  ::|       :|.::
Human   715 -IFLILLNTAAQVAYVL-QDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVL 777

  Fly   801 VGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATG 865
            .|||..|.:::..:   ..::.|...|||::|:..|.:||  .|..|.:..|.|.|...:.....
Human   778 FGIARSLLVFYVLV---NSSQTLHNKMFESILKAPVLFFD--RNPIGRILNRFSKDIGHLDDLLP 837

  Fly   866 ----QRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTME 926
                ..|.|::|.:..:::.:|:   ..|    :|:...|..:|..:::|..:  |.....|.:|
Human   838 LTFLDFIQTLLQVVGVVSVAVAV---IPW----IAIPLVPLGIIFIFLRRYFL--ETSRDVKRLE 893

  Fly   927 NCTKLAV-----EVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFF 986
            :.|:..|     ..:..:.|:.:...||...:.:         .:.::.|.......|..|..|.
Human   894 STTRSPVFSHLSSSLQGLWTIRAYKAEERCQELF---------DAHQDLHSEAWFLFLTTSRWFA 949

  Fly   987 AY--AACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRR 1049
            ..  |.|..:   .:|   :.||.:. :::.|..|...:  ||::|..:.       .:|.:..|
Human   950 VRLDAICAMF---VII---VAFGSLI-LAKTLDAGQVGL--ALSYALTLM-------GMFQWCVR 998

  Fly  1050 QPSIVDRPGVS--------------------RDP--WHSEGYVRFDKVKFSYPTRSEIQVLKGLE 1092
            |.:.|:...:|                    |.|  |..||.:.||.|.|.|.....: |||.|.
Human   999 QSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL-VLKHLT 1062

  Fly  1093 LAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPIL 1157
            ..:...:|:.:||.:|.|||:.|..:.|..: .||...||:.....:.:.:||.::.|:.|||:|
Human  1063 ALIKSQEKVGIVGRTGAGKSSLISALFRLSE-PEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVL 1126

  Fly  1158 FDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIA 1222
            |..|:|:|:   |.....||:|:.:|.::..:.|.|.:||...||.:.|.|:..|.||:|.:.:|
Human  1127 FTGTMRKNL---DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLA 1188

  Fly  1223 RALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVC 1287
            ||::|..:|:::||||:.:|..:::::|..:.......|.::|||||:|::.||.|.|.::|.:.
Human  1189 RAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLK 1253

  Fly  1288 EAGDHKQLLANR-GLYY----TLYKLQSGAM 1313
            |..:...||.|: .|:|    .|.|.::.|:
Human  1254 EYDEPYVLLQNKESLFYKMVQQLGKAEAAAL 1284

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 301/1324 (23%)
ABC_membrane 92..382 CDD:279056 57/293 (19%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 67/237 (28%)
ABC_membrane 750..1020 CDD:279056 54/305 (18%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 81/243 (33%)
ABCC4NP_005836.2 CFTR_protein 11..1269 CDD:273530 298/1314 (23%)
ABC_membrane 96..365 CDD:294371 57/297 (19%)
ABCC_MRP_domain1 410..610 CDD:213217 62/219 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 657..688 6/30 (20%)
ABC_membrane 718..991 CDD:279056 56/312 (18%)
ABCC_MRP_domain2 1039..1258 CDD:213211 75/223 (34%)
PDZ-binding 1322..1325
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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