Protein Alignment Mdr50 and LOC100496268

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: XP_004921510.2
• Gene: LOC100496268 / 100496268
• -ID: -
• Length: 1284
• Species: Xenopus tropicalis
• Alignment Length: 1325
• Identity: 581/1325 - (43%)
• Similarity: 810/1325 - (61%)
• Gaps: 64/1325 - (4%)

  Fly     2 TVKNGD----VVKDDVNSRSQYKTNIVLGAKLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGS 62
            ||.||.    |...|.||.|                :::|.|. ::.|||.|.::...
 Frog     7 TVVNGSADVTVAISDPNSNS----------------KEKKGFF-SRFKKKEKTEKPPT------- 47

  Fly    63 QYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGK 127
                    |..|.:|||::..||.|.:.|.:::::.|...|...::||::.:..:::|.:.....
 Frog    48 --------VGVFTMFRYSSTSDRILMLFGTIASISHGAALPLMMIVFGDMTDSFVNVGQVGSGNF 104

  Fly   128 SYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDM 192
            |..|....|..|.:::..::...:.:|..:|:.:|:.|:.:..:|..||..|||.||.::|.|::
 Frog   105 SLEALINASRNLQEQMTTYAYYYSGLGFGVLLFAYVQISFWTLSAGKQIKRIRSNFFHAVLRQEI 169

  Fly   193 KWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLT 257
            .|:|.|.:||:.:|:.:|:||:.:|:.:|:.|.:..|..||...::.|||||:|:||.|...|:.
 Frog   170 GWFDVNDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTFVTGFIIGFVKGWKLTLVILAISPVM 234

  Fly   258 FIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIK 322
            ..:..:.|...|....||:..||.|..|||..||.||||.||.|:.||:..|::.:..||.:.||
 Frog   235 GFSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQDKEIKRYEKNLEEAKRIGIK 299

  Fly   323 RNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMA 387
            :.:.:.:..|..:..|||:||||||||..|:|.|       .|..|:::||||:|::|:..:|..
 Frog   300 KAITANVSIGFAFLMIYAAYALAFWYGTTLIING-------GYTIGSVLTVFFAVIIGAFAVGQT 357

  Fly   388 APYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKL 452
            :|.:|||..|:||...:|:||:..|:|:....||.|.::....||||.|:|.||:|.::.:|..|
 Frog   358 SPNVEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFKNVKFTYPSRTDIQVLKGL 422

  Fly   453 NLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPI 517
            ||.|..|:||||||.|||||||.:||:||||||:.|.:..:|.:::.|:|.:||..||||.||||
 Frog   423 NLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEEGVITLDGQDIRSLNIRYLREIIGVVSQEPI 487

  Fly   518 LFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIAR 582
            ||.|:|.:||||||||.|.||||.|...|||..||.|||..::|||||||.||||||||||||||
 Frog   488 LFDTTIADNIRYGREDVTMEEIERATKEANAYNFIMKLPDKFETLVGERGTQLSGGQKQRIAIAR 552

  Fly   583 ALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVE 647
            ||:|:|:|||||||||||||.||:.|||||:|...|||||:|||||||:|.||.|...:.|.:||
 Frog   553 ALVRNPKILLLDEATSALDTESESVVQAALDKAREGRTTIVVAHRLSTIRNADVIAGFDNGVIVE 617

  Fly   648 SGTHQELMELKDHYFNLVTTQLGEDDGSV-------LS---PTGDIYKNFDIKDEDEEEIKVLSE 702
            .|.|:|||:....||||||.|..|.....       ||   |......|...:......||.::|
 Frog   618 QGGHKELMDKGGVYFNLVTLQTVETSKDTEENLELNLSEKIPLSHTSSNLVRRKSSRHTIKKVTE 682

  Fly   703 -DEDEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVL 766
             |..|:|   ||:.|||:    ..|..|. .|:||::||.||....||.|.::|.|...|.||::
 Frog   683 TDNKEEV---DEEGKKKE----DGPPPVS-FLKVMRLNKTEWPYFVVGIICAMINGATQPAFAII 739

  Fly   767 FGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAM 831
            |..|:.:.:...::  :|..|..|||.||..|.:..|..|||.:.||.|||.||:|||...|::|
 Frog   740 FSKIIGVFAGPASE--MRAKSTMYSLLFLALGGISFITFFLQGFTFGKAGEILTKRLRLWSFKSM 802

  Fly   832 LRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVA 896
            ||||:.||||..|.||:|..||:.||:.||||||.|:..:.|:|:.|...:.:|..|.|.|.|:.
 Frog   803 LRQEIGWFDDTKNSTGALTTRLATDASQVQGATGSRLALLAQNIANLGTAVIISFIYGWRLTLLI 867

  Fly   897 LAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIP 961
            ||..|.|..:..:|..:.|.......|.:|...|::.:.|.|||||.||.||..|...|...|..
 Frog   868 LAIVPIIAASALVQLKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKNLEG 932

  Fly   962 AVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANA 1026
            ....|.:..|..||.|.|::::|:||||.|..:|.:.|....:...|||.|..|::.|..::...
 Frog   933 PYRNSIKKAHLHGLTYALSQAIMYFAYAGCFRFGAYLVAELLMTPDDVFLVFSAIVFGAMALGQT 997

  Fly  1027 LAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGL 1091
            .:|||:..|.:.:|..||:.|.|.|.|.........|.:..|.|:|..|:|:||||.:|.||:||
 Frog   998 SSFAPDYTKAMISAAHIFSLLERVPLIDSYSKEGEKPQNCGGNVQFQGVQFNYPTRPDITVLQGL 1062

  Fly  1092 ELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPI 1156
            :::|.:|:.:||||.|||||||.:.|::||||...|..|:|...||::::..:|.|:||||||||
 Frog  1063 DISVKQGETLALVGSSGCGKSTTVSLLERFYDPFGGEVLVDGHSVRDLNIQWVRAQMGIVSQEPI 1127

  Fly  1157 LFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAI 1221
            |||.:|.|||:||||:|.||..||.:|.|::|||.||..|...|:||:|:||.|:||||||||||
 Frog  1128 LFDCSIGENIAYGDNSREVTQAEIETAAKEANIHSFIDTLTDKYNTRVGDKGTQMSGGQKQRIAI 1192

  Fly  1222 ARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLV 1286
            ||||:|.|||:||||||||||.|||||||:|||.|..|||.|.|||||||:.::|.|.|.:||.|
 Frog  1193 ARALVRKPKILLLDEATSALDTESEKVVQEALDKARTGRTCIVIAHRLSTIQNADKIAVIQNGKV 1257

  Fly  1287 CEAGDHKQLLANRGLYYTLYKLQSG 1311
            .|.|.|:|||..:|:||||..:|.|
 Frog  1258 VEQGTHQQLLQLKGVYYTLVTIQLG 1282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	564/1249 (45%)
		ABC_membrane	92..382	CDD:279056	97/289 (34%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	152/236 (64%)
		ABC_membrane	750..1020	CDD:279056	104/269 (39%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	144/238 (61%)
LOC100496268	XP_004921510.2	PTZ00265	1..1279	CDD:240339	579/1320 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3111
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55496
Inparanoid	1	1.050	1029	1.000	Inparanoid score	I275
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		otm47420
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060