Protein Alignment Mdr50 and XB950724

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: XP_017950348.2
• Gene: XB950724 / 100494740
• XenbaseID: XB-GENE-950725
• Length: 1381
• Species: Xenopus tropicalis
• Alignment Length: 1386
• Identity: 569/1386 - (41%)
• Similarity: 794/1386 - (57%)
• Gaps: 139/1386 - (10%)

  Fly    31 DSDRDRKSFEPN-------KSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALY 88
            ||..|.:.:|..       ||.::::.:.||...:|          .|.:..:.|:|...|..|.
 Frog    24 DSHHDFQYYEKTADNEGAPKSNEEARKNSSDKPSKE----------MVGFLDMVRFADAWDILLM 78

  Fly    89 VIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLD-KVRQFSLQNTY 152
            :.||..|||.|...|...::||::.:..: |.|:..:..|  ...:|..:.|: |:.::|.....
 Frog    79 ITGLFCAVANGTGLPLLIIVFGDMTDSFV-LSGINVTNVS--GCGSIPGIDLEAKMTRYSYYYIG 140

  Fly   153 IGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDG 217
            :|..:.|.|.:.|..|..:|..||:.||..||:::|||||.|:|.||.|.:.:|:.:|::.:.:|
 Frog   141 LGSAVFVLSLIQIWTFLVSATRQIMRIRQIFFKAVLHQDMAWFDSNQVGTLNTRLTDDINTIHEG 205

  Fly   218 LAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGA 282
            |.:|:.:||.:|.:||..:|:.||.||:|:||.|:..||...:..:.....:....||:..||.|
 Frog   206 LGDKMCIFVQFLSSFVSGIVVGFVHGWKLTLVILSVSPLLGASAAIWTKLVASFTTKELHAYAKA 270

  Fly   283 AVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFW 347
            ..|||..|:.||||.||.|:.|....|...::.||.:.||:.:.:.:..||..|.|:.:||||||
 Frog   271 GAVAEEILTAIRTVIAFNGQKKAQDKYDANLITAKTVGIKKAVTTNVSMGLSQFLIFGAYALAFW 335

  Fly   348 YGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIP 412
            ||..|.:   .||  |.|..|.::.|||||::|:..:|.|.|.||:...|:||...|::||.:..
 Frog   336 YGTKLTV---DEP--ETYTIGKVLIVFFSVLVGTFALGQATPNIESLANARGAAFAVYNIINKHR 395

  Fly   413 EINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQ 477
            .|:....||.|.|.....||||.:.|.||.||:|.||:.||||:..|:|:||||.|||||||.||
 Frog   396 PIDSSSEEGHKPNRLKGDIEFKNIHFAYPCRPDVQILSGLNLKVEAGKTIALVGMSGCGKSTTIQ 460

  Fly   478 LVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAA 542
            |:||||||..|.:..:|.:::.|::.|||..||||.|||:||.|:|.||||:|||..|..|||.|
 Frog   461 LLQRFYDPSHGEITLDGHDIRTLNVKWLRENIGVVSQEPVLFGTTIAENIRFGRESVTDSEIEQA 525

  Fly   543 AAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAK 607
            |..|||..||.:||..:.|:||||||||||||||||||||||:|:|:|||||||||||||.|||.
 Frog   526 AKEANAFDFISRLPDKFKTMVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTQSEAI 590

  Fly   608 VQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQ-LGE 671
            |||||:|..||||||::||||||:|.||.|...:.|.|||.|:|.|||..|..|::||..| .||
 Frog   591 VQAALDKARAGRTTIVIAHRLSTIRTADVIAGFHNGVVVEKGSHSELMTKKGVYYSLVMLQKQGE 655

  Fly   672 DDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDE---DEDVM------------------------ 709
            |.|.              :|.::||...|..:|   :||.:
 Frog   656 DSGP--------------EDNEQEEHSFLETEETYLNEDCLSPEADPAHQAVECTDFFRRESFRG 706

  Fly   710 ----VTDEKNKKKKKKKVKDPNEVKPML------EVMKMNKPEWLQIAVGCISSVIMGCAMPIFA 764
                |.::|:..:|.|.:::..|.|.:|      .::::||||||.|.:|.|::.|.|...|.||
 Frog   707 RNDTVNNKKSTLRKSKSLENIKEAKEILPEVSLNRILQLNKPEWLYIVIGIIAAAISGGIYPTFA 771

  Fly   765 VLFGSIL---------------QILSVKDNDQ---------------YVRENSNQY--------- 790
            |:||.::               ..:.:|...|               |...|:..|
 Frog   772 VIFGKVIGAGVHYSFIHMIHEFLFILIKSGSQQRFYSDVLLTFGLACYFISNAGNYEYVFFFYLI 836

  Fly   791 ----------------------SLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLR 833
                                  ||.|.:.|::.........:.||.:||.||.|||.|.|:|:|.
 Frog   837 RCLLQAFQEQDPVKKSQRTALLSLMFFVLGLISFAVHITMGFMFGKSGENLTMRLRSLSFKALLG 901

  Fly   834 QEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALA 898
            ||:.:|||..|..|.|..||:.||:.::||.|.::|.|..::.||...|.::..:.|.|.|:.||
 Frog   902 QEIGFFDDHRNAVGVLLTRLATDASQIKGAAGSQLGLITMTVCTLLAAILIAFIHGWQLTLLILA 966

  Fly   899 FTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAV 963
            ..||::....::.|.:|.......|.:|...:::.|.|.|||||.||.:||:|::.|...|....
 Frog   967 CIPFLIGTNIIRMTSVAGHASKDQKALEEAGRISTEAVENIRTVVSLTKEEVFYEKYNASLNGPY 1031

  Fly   964 EISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALA 1028
            .::.......|:.|.:|:.:.:|..||...:|.|.:.:..:.|..||.|..|::....|:..:.:
 Frog  1032 RVALGKARMYGVTYAIAQCINYFVNAAVFRFGAWLIANCYMEFESVFVVFSAIVFAAMSVGQSNS 1096

  Fly  1029 FAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLEL 1093
            |||:..|..|:|:.:|..|.|:|:|.............||.:.|..|||.||||..:|||:||.:
 Frog  1097 FAPDFGKAKSSAQRMFLLLDRKPAIDSYSNEGETLNEFEGNLEFKNVKFVYPTRPNVQVLQGLNV 1161

  Fly  1094 AVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILF 1158
            .|.|||.:||||.|||||||.|||::||||..||..|.|..|.:::::..||:|||:||||||||
 Frog  1162 KVLKGQTLALVGSSGCGKSTLIQLLERFYDPMEGNVLADGVDTKSLNIQWLRSQLGLVSQEPILF 1226

  Fly  1159 DRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIAR 1223
            |.:|.|||.||||.|.||..|:..|.|.:|||.|:.:||.|||||:|:|||||||||||||||||
 Frog  1227 DCSIGENIRYGDNNRVVTQDEVAEAAKTANIHTFVESLPQGYDTRVGDKGAQLSGGQKQRIAIAR 1291

  Fly  1224 ALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCE 1288
            ||:|.||::||||||||||.|||||||.|||.|.:|||.|.|||||:||.::|||.|.:||.|.|
 Frog  1292 ALVRKPKVLLLDEATSALDTESEKVVQKALDDARKGRTCIVIAHRLTTVQNADVIAVIQNGEVVE 1356

  Fly  1289 AGDHKQLLANRGLYYTLYKLQ 1309
            .|.|.||||.:|.||.|...|
 Frog  1357 QGTHNQLLAKQGAYYALINSQ 1377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	559/1338 (42%)
		ABC_membrane	92..382	CDD:279056	104/290 (36%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	151/236 (64%)
		ABC_membrane	750..1020	CDD:279056	89/330 (27%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	152/238 (64%)
XB950724	XP_017950348.2	PTZ00265	77..1371	CDD:240339	552/1315 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3111
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1029	1.000	Inparanoid score	I275
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		otm47420
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060