Protein Alignment Mdr50 and abcb11

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: XP_031749510.1
• Gene: abcb11 / 100489744
• XenbaseID: XB-GENE-29079871
• Length: 1296
• Species: Xenopus tropicalis
• Alignment Length: 1327
• Identity: 551/1327 - (41%)
• Similarity: 781/1327 - (58%)
• Gaps: 99/1327 - (7%)

  Fly    45 KKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIF 109
            |||.|..|.                :|.:|||||:|:..|:.:.|||.|.|:..|...|...||:
 Frog     7 KKKKKEKEI----------------RVGFFQLFRFASATDKVMMVIGALCALIHGAAQPLMLLIY 55

  Fly   110 GNLA---------------------NDMIDLGGLLESGKSYRADD---AISTLLLDKVRQFSLQN 150
            |.:.                     ||.|    ..::|..|..|:   |..|.:..|:.:|:...
 Frog    56 GMMTDTFITYDRETQELQDINKECINDTI----WWKNGTEYIVDNSTVACGTNIEKKMTEFAYYY 116

  Fly   151 TYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKME 215
            ..||||:||.||..|:.:..||..||..:|.::||.|:..|:.|:|.|..||:.:|:::|::|:.
 Frog   117 IGIGIIVLVLSYFQISLWVVAAARQIQIVRKEYFRKIMRLDIGWFDSNSVGELNTRISDDINKIN 181

  Fly   216 DGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYA 280
            :.:|::|.:|:..:..|:...::.||..|:|:||.:...||..:..||:|||.:||..:|:..||
 Frog   182 NAIADQVAIFIERISTFIFGFLIGFVGNWKLTLVIVAVSPLIGLGAGLMAVAVARLTGRELKAYA 246

  Fly   281 GAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALA 345
            .|..||:..||.||||.||.||.||...|.:.:..|:...|::....|...|.:|..|:..|:||
 Frog   247 KAGSVADEVLSAIRTVAAFGGEKKEAERYDDNLEEAQTWGIRKGTIIGFFQGYMWCIIFLCYSLA 311

  Fly   346 FWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQ 410
            ||||..|||:      ......|:::.|||.|::.:||:|.|:|.:|||...:.|...::..|:.
 Frog   312 FWYGSRLVIE------TRELSPGSLLQVFFGVLVAAMNLGQASPCLEAFASGRAAATIIYETIDL 370

  Fly   411 IPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTC 475
            .|.|:.:..||.||::....|||..|.|.||:||::..|:.|::.|..|:|.|.|||||.|||:.
 Frog   371 NPVIDCMSEEGHKLDQVKGDIEFHNVNFCYPSRPDIKSLSDLSISIKPGETTAFVGPSGSGKSSA 435

  Fly   476 IQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIE 540
            :||:||||||..|.:..:|.:|:.|:..||||.||:|.|||:||||:|.|||.|||:..|..:||
 Frog   436 VQLIQRFYDPTDGKVTLDGHDLRTLNTKWLRSLIGIVEQEPVLFATTIAENISYGRDGVTMNDIE 500

  Fly   541 AAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASE 605
            .||..|||..||..||:.:||||||.|.|:||||||||||||||||:|:|||||.||||||..||
 Frog   501 KAAKDANAYNFIMDLPQKFDTLVGEGGGQMSGGQKQRIAIARALIRNPKILLLDMATSALDNESE 565

  Fly   606 AKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLG 670
            |.||.||.||.:|||||.:||||||||.||.||..:.|..||.|.|:|||:||..||.|||.|..
 Frog   566 AIVQEALNKVQSGRTTISIAHRLSTVRTADIIVGFDGGRAVEKGNHEELMKLKGVYFTLVTLQNQ 630

  Fly   671 EDDGSVLSPTGDI------------YKNF---DIKDEDEEEIK---------------VLSEDED 705
            .:..:..:.|.|:            |::.   .::...:.::.               |..|||.
 Frog   631 NNSSAEKTATEDVAAEKEKPFIRGSYRSSLRNTLRLRSKSQLSNIFPVPLSGTVNGTAVPVEDEI 695

  Fly   706 EDVMVTDEKNKKKKKKKVKDPNEVKPML-EVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGS 769
            .:.:.|.||.|||.||.       |.:: .|:|.|..||..:.||.|.:.|.|...|::|:||..
 Frog   696 MEPVETKEKEKKKGKKN-------KSVIGRVLKYNTKEWPYLLVGSIGAAINGVVTPLYAILFSQ 753

  Fly   770 ILQILSVKD-NDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLR 833
            ||...|:.| |:|  |...|...:.|:|..:|..:..|.|.|.|..:|||||.|||.:.|:|||.
 Frog   754 ILGTFSLPDLNEQ--RREINGICILFVIIAVVSFVTQFFQGYAFAKSGERLTRRLRRVGFQAMLG 816

  Fly   834 QEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALA 898
            ||:.||||..|..|:|..||:.||:.||||||.:||.:|.|::.:...:.::.|:.|.|.||.|.
 Frog   817 QEIGWFDDNNNSPGALTTRLATDASQVQGATGSQIGMVVNSLTNIGASLIIAFYFSWKLSLVVLC 881

  Fly   899 FTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAV 963
            |.|.:.:|...|..::..........:|...|::.|.:.||||||.||:|.||.:.|...|....
 Frog   882 FLPLLALAGVFQAKMLTGFANQDKNALEMAGKVSSEAIGNIRTVAGLGKETMFVEVYEKQLELPY 946

  Fly   964 EISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALA 1028
            :.:.:.:|..|..:|.|:.::|.||||...:|.:.|...||.:..||:|..|::....::..|.:
 Frog   947 KAAVKKSHVYGACFGFAQCVIFMAYAASFRFGGFLVNTDGIHYAVVFRVISAIVTSGTALGRASS 1011

  Fly  1029 FAPNMQKGVSAAKTIFTFLRRQP--SIVDRPGVSRDPWHS-EGYVRFDKVKFSYPTRSEIQVLKG 1090
            |.|:..|...||:..|..|.|.|  |:....|   |.|.. :|.:.|...||:||:|....||:|
 Frog  1012 FTPDYAKAKIAAEQFFKLLDRVPKTSVFSSSG---DKWEEFKGDIEFVNCKFTYPSRPVTMVLRG 1073

  Fly  1091 LELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEP 1155
            |.::|..||.:|.||.|||||||.:||::||||.|||..|:|.....||:::.||:::|||||||
 Frog  1074 LSISVRSGQTLAFVGSSGCGKSTSVQLLERFYDPDEGKVLVDGHATANVNISFLRSKIGIVSQEP 1138

  Fly  1156 ILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIA 1220
            :||:.:|.:||.||||:|::..:|:|.|.||:::|||:..||..|:|.:|.:|:|||.|||||||
 Frog  1139 VLFEGSIADNIKYGDNSRDIPMEEVIEAAKKAHLHEFVMTLPDQYETNVGIQGSQLSRGQKQRIA 1203

  Fly  1221 IARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGL 1285
            ||||::|:|||:||||||||||.||||.||.|||.|.:|||.|:|||||||:...|:|.|...|.
 Frog  1204 IARAIVRDPKILLLDEATSALDTESEKTVQAALDEARKGRTCIAIAHRLSTIQTCDIIAVMSQGA 1268

  Fly  1286 VCEAGDHKQLLANRGLYYTLYKLQSGA 1312
            :.|.|.|:.|:|.:|.||.|  :.:||
 Frog  1269 IVEKGSHEALMALKGAYYKL--VTTGA 1293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	544/1297 (42%)
abcb11	XP_031749510.1	PTZ00265	16..1287	CDD:240339	542/1292 (42%)