DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and abcb11.2

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	XP_004917764.1	Gene:	abcb11.2 / 100489579	XenbaseID:	XB-GENE-988819	Length:	1349	Species:	Xenopus tropicalis

Alignment Length:	1362	Identity:	550/1362 - (40%)
Similarity:	791/1362 - (58%)	Gaps:	115/1362 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EDSDRDRKSFEPNKS-KKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLL 93
            ||||..:::.:.|:: ...||.|||        .:..||..:|.:|||||:||..:..:.:.|.|
Frog    21 EDSDNYKETVDLNQNGNASSKKDES--------KKKPEDSIRVGFFQLFRFATCSETTMMLFGSL 77

  Fly    94 SAVATGLTTPANSLIFGNLANDMIDL-----------------------GGLLESGKSYRADDAI 135
            :|:..|...|...|:||.:.:..|:.                       |.|:..    :.:...
Frog    78 AAIIHGAAQPCMLLVFGLMIDTFIEYDIEMQELRDPNKTCTNNTITWTNGSLVPD----KDNKTF 138

  Fly   136 STLLLD---KVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDF 197
            |..:||   ::..|:.....||..:|:..|:.|..:..||..||..||..:||.::..::.|:|.
Frog   139 SCGMLDIELEMTNFASYYAGIGCSVLILGYMQICFWVTAAARQIQRIRKLYFRKVMRMEIGWFDC 203

  Fly   198 NQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMG 262
            ...||:.:||::|::|:.|.:|::|.:|:.....|:...:|.||.||:|:|:.:...||..:...
Frog   204 TSVGELNTRMSDDINKINDAIADQVGIFIQRFTTFLSGFLLGFVNGWKLTLIIIAVSPLIGVGAA 268

  Fly   263 LVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFS 327
            |:|:|.::|..:|:..||.|..||:..|||||||.||.||.|||..|...:|.|:...|::.:..
Frog   269 LMALAVAKLTGRELLAYAKAGAVADEVLSGIRTVAAFGGETKEVDRYDRNLVYAQRWGIRKGIIM 333

  Fly   328 GIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIE 392
            |...|.:||.|:..||||||||..||::      .|.|..|.::.||..|::|::|:|.|:|.::
Frog   334 GFFTGYMWFIIFLCYALAFWYGSKLVLE------EEEYSPGNLLQVFLGVLVGALNLGQASPCLQ 392

  Fly   393 AFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIH 457
            ||...:||...:|..|:..|:|:.:..||.||::....|||..:.|.||:||||.||:|:|:.|.
Frog   393 AFASGRGAATNIFETIDNEPKIDCMSEEGYKLDKVKGEIEFHNISFHYPSRPEVKILDKINMVIK 457

  Fly   458 RGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATS 522
            .|:|.|.|||||.||||.:||:||||||..|.:..:|.:::.|:|.||||.||:|.|||:||||:
Frog   458 SGETTAFVGPSGAGKSTTVQLIQRFYDPDVGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFATT 522

  Fly   523 IYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRD 587
            |.||||||:|:||.|||..||..|||..||..||:.:||||||.|.|:||||||||||||||:|:
Frog   523 IAENIRYGKENATMEEIITAAKEANAYNFIMDLPQKFDTLVGEGGGQMSGGQKQRIAIARALVRN 587

  Fly   588 PEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQ 652
            |.|||||.||||||..|||.||.||:||..|||||.:||||||::.||.||....|..||.|||.
Frog   588 PRILLLDMATSALDNESEAIVQEALDKVRFGRTTISIAHRLSTIKNADVIVGFEHGRAVEKGTHD 652

  Fly   653 ELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIK------------------- 698
            ||:|.|..||.|||.|...|..         ..|.:.||:..:|.:
Frog   653 ELLERKGVYFTLVTLQSQGDKA---------LHNMEKKDKSNKEFEEPKLETLQPLKRGSYQASL 708

  Fly   699 ----------------------VLSEDEDEDVM----VTDEK-NKKKKKKKVKDPNEVKPMLEVM 736
                                  |:..|..:.:.    ..||. |...|.:::.:..|..|:..::
Frog   709 RASIRQRSRSQLSNLVPDTPLLVVGADASDPIQHSTHYDDESDNNMIKTEEIVEDIEPAPVARIL 773

  Fly   737 KMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVV 801
            |.|.|||..:..|.|.:.|.|...|::|:||..||.|.|:.|.::. |:..|...:.|::.|:|.
Frog   774 KYNAPEWPYMLFGSIGAAINGAVSPLYALLFSQILGIFSLPDEEEQ-RDQINGICVLFVLIGVVS 837

  Fly   802 GIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQ 866
            .:..|||.|.|..:||.||.|||.|.|.:||.|||.||||..|..|:|..||:.||:.||||||.
Frog   838 FLTQFLQGYTFAKSGELLTRRLRKLGFRSMLGQEVGWFDDPRNSPGALTTRLATDASQVQGATGS 902

  Fly   867 RIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKL 931
            :||.||.:||.:.:.:.::.|:.|.|.||.:.|.||:.::..:|..::..........||:..::
Frog   903 QIGMIVNAISNIGVALIIAFYFSWKLTLVIMCFLPFLAVSGALQAKMLTGFANQDKHAMESAGRI 967

  Fly   932 AVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGT 996
            :.|.:.||||:|.:.:|:.|...|...|......:.:..:..||.:|.|:.::|.|......||.
Frog   968 SSEALGNIRTIAGIAKEKTFVDMYEEQLEAPYRSAIKKANVYGLCFGFAQCIVFIANTVSYRYGG 1032

  Fly   997 WCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSR 1061
            :.|...|:.:..||:|..:::....::..|.::.|:..|...:|...|..:.|.|.|    .|..
Frog  1033 YLVDKEGLHYSFVFRVISSIVTSGTALGRASSYTPDYAKAKISAARFFKLVDRIPKI----SVYT 1093

  Fly  1062 DPWHSE------GYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQR 1120
            |  |.|      |.:.|...||:||||.:||||.||:::|..||.:|.||.|||||||.:||::|
Frog  1094 D--HGERWPDFKGSIDFQDCKFTYPTRPDIQVLNGLDVSVKPGQTLAFVGSSGCGKSTSVQLLER 1156

  Fly  1121 FYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACK 1185
            |||.|:|..|||..:.:||::..||:::|||||||:|||.:|.|||.||||.:.::..:||.|.|
Frog  1157 FYDPDKGKVLIDGHNSKNVNVAFLRSKIGIVSQEPVLFDCSIIENIRYGDNNQELSKDKIIEASK 1221

  Fly  1186 KSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQ 1250
            |:.:|:|:..||..|||.:|..|:|||.|||||||||||::|:|||:||||||||||.||||.||
Frog  1222 KAQLHDFVMGLPDKYDTNVGAHGSQLSRGQKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQ 1286

  Fly  1251 DALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQSGA 1312
            .|||.|.||||.|.|||||||:.:||:|.|...|:|.|.|:|::|:..:|.||.|  :.:||
Frog  1287 AALDRAREGRTCIVIAHRLSTIQNSDIIAVMSRGIVIEKGNHEELMEKKGAYYKL--VTTGA 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	536/1316 (41%)
		ABC_membrane	92..382	CDD:279056	99/315 (31%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	149/236 (63%)
		ABC_membrane	750..1020	CDD:279056	93/269 (35%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	137/238 (58%)
abcb11.2	XP_004917764.1	PTZ00265	159..1340	CDD:240339	511/1202 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3111
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1029	1.000	Inparanoid score	I275
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		otm47420
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060