Protein Alignment Mdr50 and abcb11.2

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: XP_004917764.1
• Gene: abcb11.2 / 100489579
• XenbaseID: XB-GENE-988819
• Length: 1349
• Species: Xenopus tropicalis
• Alignment Length: 1358
• Identity: 550/1358 - (40%)
• Similarity: 793/1358 - (58%)
• Gaps: 107/1358 - (7%)

  Fly    30 EDSDRDRKSFEPNKS-KKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLL 93
            ||||..:::.:.|:: ...||.|||        .:..||..:|.:|||||:||..:..:.:.|.|
 Frog    21 EDSDNYKETVDLNQNGNASSKKDES--------KKKPEDSIRVGFFQLFRFATCSETTMMLFGSL 77

  Fly    94 SAVATGLTTPANSLIFGNLANDM----IDLGGLLESGKSY---------------RADDAISTLL 139
            :|:..|...|...|:||.:.:..    |::..|.:..|:.               :.:...|..:
 Frog    78 AAIIHGAAQPCMLLVFGLMIDTFIEYDIEMQELRDPNKTCTNNTITWTNGSLVPDKDNKTFSCGM 142

  Fly   140 LD---KVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSG 201
            ||   ::..|:.....||..:|:..|:.|..:..||..||..||..:||.::..::.|:|....|
 Frog   143 LDIELEMTNFASYYAGIGCSVLILGYMQICFWVTAAARQIQRIRKLYFRKVMRMEIGWFDCTSVG 207

  Fly   202 EVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAV 266
            |:.:||::|::|:.|.:|::|.:|:.....|:...:|.||.||:|:|:.:...||..:...|:|:
 Frog   208 ELNTRMSDDINKINDAIADQVGIFIQRFTTFLSGFLLGFVNGWKLTLIIIAVSPLIGVGAALMAL 272

  Fly   267 ATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGF 331
            |.::|..:|:..||.|..||:..|||||||.||.||.|||..|...:|.|:...|::.:..|...
 Frog   273 AVAKLTGRELLAYAKAGAVADEVLSGIRTVAAFGGETKEVDRYDRNLVYAQRWGIRKGIIMGFFT 337

  Fly   332 GLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGI 396
            |.:||.|:..||||||||..||::      .|.|..|.::.||..|::|::|:|.|:|.::||..
 Frog   338 GYMWFIIFLCYALAFWYGSKLVLE------EEEYSPGNLLQVFLGVLVGALNLGQASPCLQAFAS 396

  Fly   397 AKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQT 461
            .:||...:|..|:..|:|:.:..||.||::....|||..:.|.||:||||.||:|:|:.|..|:|
 Frog   397 GRGAATNIFETIDNEPKIDCMSEEGYKLDKVKGEIEFHNISFHYPSRPEVKILDKINMVIKSGET 461

  Fly   462 VALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYEN 526
            .|.|||||.||||.:||:||||||..|.:..:|.:::.|:|.||||.||:|.|||:||||:|.||
 Frog   462 TAFVGPSGAGKSTTVQLIQRFYDPDVGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFATTIAEN 526

  Fly   527 IRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEIL 591
            ||||:|:||.|||..||..|||..||..||:.:||||||.|.|:||||||||||||||:|:|.||
 Frog   527 IRYGKENATMEEIITAAKEANAYNFIMDLPQKFDTLVGEGGGQMSGGQKQRIAIARALVRNPRIL 591

  Fly   592 LLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELME 656
            |||.||||||..|||.||.||:||..|||||.:||||||::.||.||....|..||.|||.||:|
 Frog   592 LLDMATSALDNESEAIVQEALDKVRFGRTTISIAHRLSTIKNADVIVGFEHGRAVEKGTHDELLE 656

  Fly   657 LKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIK----------------------- 698
            .|..||.|||.|...|..         ..|.:.||:..:|.:
 Frog   657 RKGVYFTLVTLQSQGDKA---------LHNMEKKDKSNKEFEEPKLETLQPLKRGSYQASLRASI 712

  Fly   699 ------------------VLSEDEDEDVM----VTDEK-NKKKKKKKVKDPNEVKPMLEVMKMNK 740
                              |:..|..:.:.    ..||. |...|.:::.:..|..|:..::|.|.
 Frog   713 RQRSRSQLSNLVPDTPLLVVGADASDPIQHSTHYDDESDNNMIKTEEIVEDIEPAPVARILKYNA 777

  Fly   741 PEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIAT 805
            |||..:..|.|.:.|.|...|::|:||..||.|.|:.|.::. |:..|...:.|::.|:|..:..
 Frog   778 PEWPYMLFGSIGAAINGAVSPLYALLFSQILGIFSLPDEEEQ-RDQINGICVLFVLIGVVSFLTQ 841

  Fly   806 FLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGT 870
            |||.|.|..:||.||.|||.|.|.:||.|||.||||..|..|:|..||:.||:.||||||.:||.
 Frog   842 FLQGYTFAKSGELLTRRLRKLGFRSMLGQEVGWFDDPRNSPGALTTRLATDASQVQGATGSQIGM 906

  Fly   871 IVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEV 935
            ||.:||.:.:.:.::.|:.|.|.||.:.|.||:.::..:|..::..........||:..:::.|.
 Frog   907 IVNAISNIGVALIIAFYFSWKLTLVIMCFLPFLAVSGALQAKMLTGFANQDKHAMESAGRISSEA 971

  Fly   936 VSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVI 1000
            :.||||:|.:.:|:.|...|...|......:.:..:..||.:|.|:.::|.|......||.:.|.
 Frog   972 LGNIRTIAGIAKEKTFVDMYEEQLEAPYRSAIKKANVYGLCFGFAQCIVFIANTVSYRYGGYLVD 1036

  Fly  1001 HRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWH 1065
            ..|:.:..||:|..:::....::..|.::.|:..|...:|...|..:.|.|.|    .|..|  |
 Frog  1037 KEGLHYSFVFRVISSIVTSGTALGRASSYTPDYAKAKISAARFFKLVDRIPKI----SVYTD--H 1095

  Fly  1066 SE------GYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDV 1124
            .|      |.:.|...||:||||.:||||.||:::|..||.:|.||.|||||||.:||::||||.
 Frog  1096 GERWPDFKGSIDFQDCKFTYPTRPDIQVLNGLDVSVKPGQTLAFVGSSGCGKSTSVQLLERFYDP 1160

  Fly  1125 DEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNI 1189
            |:|..|||..:.:||::..||:::|||||||:|||.:|.|||.||||.:.::..:||.|.||:.:
 Frog  1161 DKGKVLIDGHNSKNVNVAFLRSKIGIVSQEPVLFDCSIIENIRYGDNNQELSKDKIIEASKKAQL 1225

  Fly  1190 HEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALD 1254
            |:|:..||..|||.:|..|:|||.|||||||||||::|:|||:||||||||||.||||.||.|||
 Frog  1226 HDFVMGLPDKYDTNVGAHGSQLSRGQKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQAALD 1290

  Fly  1255 AASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQSGA 1312
            .|.||||.|.|||||||:.:||:|.|...|:|.|.|:|::|:..:|.||.|  :.:||
 Frog  1291 RAREGRTCIVIAHRLSTIQNSDIIAVMSRGIVIEKGNHEELMEKKGAYYKL--VTTGA 1346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	536/1312 (41%)
abcb11.2	XP_004917764.1	PTZ00265	159..1340	CDD:240339	511/1202 (43%)
		MdlB	767..1344	CDD:440747	250/585 (43%)