DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and abcc8b

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	XP_021323602.1	Gene:	abcc8b / 100329706	ZFINID:	ZDB-GENE-120215-45	Length:	1607	Species:	Danio rerio

Alignment Length:	1374	Identity:	287/1374 - (20%)
Similarity:	515/1374 - (37%)	Gaps:	357/1374 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 NTYIGIIMLVCSYLSITCFNYAAHSQIL--------TIRSKFFRSILH---QDMKWYDFNQSGEV 203
            |.|:..::|..:.|....|..|::...:        .:::|.:..|:.   .:|...|.. :.::
Zfish   369 NAYVLAVLLFLALLLQRTFLQASYYVAIENGINLRGAVQTKIYNKIMRLCTSNMSMGDMT-TAQI 432

  Fly   204 ASRMNEDLSKMEDGLAEKVVMFVHYLV---------AFVGSLVLAFVKGWQ--LSLVCLTSL-PL 256
            .:.:..|.:::         |:..:|.         ..:|.|:|.::.|..  :....:|.| ||
Zfish   433 CNLVARDTNQL---------MWFFFLCPNLWAMPVQIVIGVLLLYYLLGASALIGATVITVLAPL 488

  Fly   257 TFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNI 321
            .:    .||...||..|..:...:.........|.||:.:|.:..         |.:..:.:...
Zfish   489 QY----FVATRLSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAW---------EHIFRSSVEET 540

  Fly   322 KRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVF-FSVMMGSMNIG 385
            :|...:    .|..|.:|.|  |:.:....:.|             ..::|:| ..|.:.|.:..
Zfish   541 RRQELT----SLRTFALYTS--LSIFMNAAIPI-------------AAVLTIFVVHVHLQSSSDF 586

  Fly   386 MAAPYIEAFGIAKGACAKVFHI----------------------------------------IEQ 410
            ..:|.: |||     ...:|||                                        |.|
Zfish   587 ALSPAV-AFG-----SLSLFHILVTPLFLLSSVLHSTVKALVSVQKLSEFLSSAEIETDQDPIAQ 645

  Fly   411 IPEINP---------------IDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSI------------ 448
            .|..|.               ::.:.|...:.....|.::.|.:...:.|.:|
Zfish   646 TPANNNGNIKSVYALQLQAKLVNRKNKAKQDVNRNFEQQDQELRASAQHEDNICIKIVNGYFSWT 710

  Fly   449 -----LNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDIN----- 503
                 |..:::|:..||...:||..|.|||:.:..........:|::.:|.....|.|.|
Zfish   711 QGCPTLTNIDIKVPFGQLTMIVGQVGSGKSSLLLAALGEMQKISGSITWNSLPRSDSDENIRAHD 775

  Fly   504 -------WLRSRIGVVGQEPILFATSIYENI---------RYGREDATREEIEAAAAAANAAIFI 552
                   ..|..:....|.|.|...::.|||         ||      ::.||......:    |
Zfish   776 MSGRQSFTRRGSVAYASQRPWLLNATVEENILFDTAPNVKRY------KDVIEVCQLGPD----I 830

  Fly   553 KKLPKGYDTLVGER----GAQLSGGQKQRIAIARALIRDPEILLLDEATSALDT-ASEAKVQAAL 612
            ..||:|..|::|||    |..|||||:|||::||||.:...::.||:..||||. .|:..:...:
Zfish   831 DTLPQGDQTVIGERVRHLGIILSGGQRQRISVARALYQQTNVVFLDDPFSALDIHLSDHLMHEGI 895

  Fly   613 EKV--SAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGS 675
            .|.  ...|:.::|.|:|..:..||.|:.:..|.|...||.:::...:...|....|.:...|
Zfish   896 LKFLRQEKRSVVLVTHKLQYLPHADWIIAMRDGTVQTQGTLKDIQCAEPELFEQWRTLMNRQD-- 958

  Fly   676 VLSPTGDIYKNFDIKDEDEEEIK--------------VLSEDEDE--DVMVTDEKNKKKKKKKVK 724
                           .|:..|:|              |.::||||  ||.|::.|:......:..
Zfish   959 ---------------KENSTELKRKSFRRAMMYSRDTVATDDEDEVADVAVSEVKDSSTSTDEDS 1008

  Fly   725 DPNEVK----------------------PMLEVMKMNKPEWLQIAVG-----CISSVIMGCAMPI 762
            ...|::                      |:|.|.::.|.. |.:|:.     ..|.||..
Zfish  1009 LGAELRHRTTIPWSSFATYLKAAGLFLLPLLIVSQLAKHS-LMVAIDFWLAHWTSDVIAA----- 1067

  Fly   763 FAVLFGSILQILSVKDNDQYVRENSNQYSLYFLI------AGIVVGIATFLQIYFFGIAGERLTE 821
                     |..|.:.|..:.::....:|.|..:      .|||:.:.|.|.:.:.|:   |:.:
Zfish  1068 ---------QSESAERNCTFTKDCVFSHSWYLQVFCLLCALGIVLCLVTSLAVEWTGL---RVAK 1120

  Fly   822 RLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQ--SISTL----AL 880
            .|...:...::...:..|:  ....|::..|.|.|...:.    |.|...::  |.|||    |:
Zfish  1121 ELHCSLLRIIVLAPMRLFE--TTPLGNILNRFSTDTNTID----QHIPVTMECLSRSTLLCVSAV 1179

  Fly   881 GIALSMYYEWSLGLVALAFTPFILIAFYMQRTL-MAKENMGSAKTMENCTKLAV-----EVVSNI 939
            |:   :.|...:.|:||  .|..:..:::|:.. :|..::   :.:|:.|::.:     :.:..:
Zfish  1180 GV---ISYVTPVFLIAL--LPLTVACYFIQKYFRVASRDL---QQLEDSTEMPLLSHYSQTIEGL 1236

  Fly   940 RTVASLGREEMF---------------------------HQNYIGMLIP--AVEISKRNTHFRGL 975
            .|:.:...|:.|                           ...|||.|:.  |...|..|..:|.|
Zfish  1237 TTIRAFRHEQRFKKKLLEHTDANNISSLFLTAANRWLEVRMEYIGALVVLIAAVASITNALYRQL 1301

  Fly   976 VYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAA 1040
            ..||....:.:|.....|. .|                         |...||   :|:..:...
Zfish  1302 SAGLVGLGLTYALMVSNYL-NW-------------------------IVRNLA---DMEVQLGCV 1337

  Fly  1041 KTIFTFLRRQPSIVDR---PGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIA 1102
            |.:...:..||...|.   |......|...|.::...:...|.: |...|||.:...:..|||:.
Zfish  1338 KRVSGLIHTQPESYDNIMTPAQVPAGWPKYGEIQIQNLSVRYDS-SLKPVLKHVSAHIRPGQKVG 1401

  Fly  1103 LVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENIS 1167
            :.|.:|.|||:....:.|..|..||...||..|:..:.:..||::..|:.|:||||..|||.|:
Zfish  1402 ICGRTGSGKSSFSLALFRMVDTFEGQISIDGIDISKLPLQTLRSKFSIILQDPILFSGTIRFNL- 1465

  Fly  1168 YGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIM 1232
              |..|..||:.:..|.:.:.:...:..||.|.|..:.|.|...|.||:|...:|||.:|...|:
Zfish  1466 --DPERKATDEMLWEALEIAQLMPVVKALPGGLDAVVTEGGENFSQGQRQLFCLARAFVRKSSIL 1528

  Fly  1233 LLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLA 1297
            ::||||:::|..:|.::|..:..|...||.::||||:.|::.|||:.|.::|.:.|..:...||.
Zfish  1529 IMDEATASIDMATESILQKVVMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIEYDEPDVLLE 1593

  Fly  1298 NRGLYYTLY 1306
            .:...::.:
Zfish  1594 QKDSVFSAF 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	287/1374 (21%)
		ABC_membrane	92..382	CDD:279056	41/255 (16%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	71/281 (25%)
		ABC_membrane	750..1020	CDD:279056	55/316 (17%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	75/237 (32%)
abcc8b	XP_021323602.1	SunT	239..1600	CDD:331423	287/1370 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000