Protein Alignment Mdr50 and abcb8

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001121515.1
• Gene: abcb8 / 100158634
• XenbaseID: XB-GENE-1010256
• Length: 688
• Species: Xenopus tropicalis
• Alignment Length: 591
• Identity: 214/591 - (36%)
• Similarity: 323/591 - (54%)
• Gaps: 38/591 - (6%)

  Fly    89 VIGLLSAVATGLTTPANSLIFG-NLANDMID--LGGLLESGKSYRADDAISTLLLDKVRQFSLQN 150
            :|.||:||.         |.|| .|.|..|.  ||.|:.....|..:.|.:.|...:.....|..
 Frog   117 LIALLTAVL---------LAFGAALLNIRIPLMLGELVNVVSRYTREHAGNYLQEVQGPALKLLC 172

  Fly   151 TYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKME 215
            .|....:|.|.|  |...:........::|...|.|:|.||:.::|..::|.:.:|:..|:.:.:
 Frog   173 LYGAQGLLTCGY--IVLLSRVGERVAGSMRKSLFFSLLRQDVAFFDAEKTGLLVNRLTSDVQEFK 235

  Fly   216 DGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYA 280
            ....:.:...:..|...||..:..:....:|:.:.|..:|:...:..|:.....:|:::.....|
 Frog   236 SSFKQVISQGLRSLTQTVGCFLSLYYISPKLTGLLLVVMPVLVGSGALIGSFLRKLSRRAQEQVA 300

  Fly   281 GAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAA----KILNIKRNMFSGIGFGLLWFFIYAS 341
            .|..:|:.||..:||||||..|::|:..|...|..:    ::|.:...:|.|:...:|...:
 Frog   301 RATGLADEALGNVRTVKAFAMESREMELYSAEVDKSSGQNEVLGVGIAVFQGLSNVVLNCIV--- 362

  Fly   342 YALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFG-IAKGACA--K 403
                    :|.:..|....:.:...||.:::  |.|...::...||...: .|| :.:|..|  :
 Frog   363 --------LGTIFAGGSLMSSKELSAGELMS--FLVASQTVQRSMANMSV-LFGQVVRGLSAGGR 416

  Fly   404 VFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPS 468
            ||..:...|.| |:.| |.||......|.||:|.|.|||||...:|...:|:|..|:||||||.|
 Frog   417 VFEFMSLEPTI-PLSG-GFKLPVLRGEIHFKDVSFSYPTRPGHEVLRSFDLRIPHGKTVALVGQS 479

  Fly   469 GCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSR-IGVVGQEPILFATSIYENIRYGRE 532
            |.||||...|::|||||..|.:..:|.:::.||.:|||.. ||.:.|||:||.|:|.||||:||.
 Frog   480 GGGKSTVAALLERFYDPTEGAVQLDGVDIRILDPSWLRGEVIGFINQEPVLFGTTIIENIRFGRP 544

  Fly   533 DATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEAT 597
            |||..|:..||..|||..||:..|:||:|::||||..||||||||:||||||::||:||:|||||
 Frog   545 DATDAEVHEAAIQANADSFIRSFPEGYNTMLGERGVTLSGGQKQRVAIARALLKDPKILILDEAT 609

  Fly   598 SALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYF 662
            |||||.||..||.||::..:|||.:::||||||:..||.|||::||:|.|.||||:|:.....|.
 Frog   610 SALDTESERAVQVALDRARSGRTVLVIAHRLSTISEADFIVVLSKGQVAEFGTHQDLLRRGGLYA 674

  Fly   663 NLVTTQ 668
            :|:..|
 Frog   675 DLIRRQ 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	214/591 (36%)
abcb8	NP_001121515.1	MdlB	106..684	CDD:440747	214/591 (36%)