DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and abcb4

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_001303643.1 Gene:abcb4 / 100136865 ZFINID:ZDB-GENE-080204-52 Length:1275 Species:Danio rerio


Alignment Length:1296 Identity:565/1296 - (43%)
Similarity:817/1296 - (63%) Gaps:56/1296 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 KSKKK----SKHDESDASDEEDGSQYHED---VKQVSYFQLFRYATKKDRALYVIGLLSAVATGL 100
            |||.|    .|.:..|.|.|::|.:..|:   ::.|...:|||||...|..|.::||:.::|.|.
Zfish     4 KSKLKVSSDKKEENGDVSGEKNGKEEKEEKEKLEMVGPIELFRYADSIDILLMMLGLIMSMANGA 68

  Fly   101 TTPANSLIFGNLANDMIDLGGLLESGK------SYRADDAISTLLLDKVRQFSLQNTYIGIIMLV 159
            ..|...::||::.:..:| ..||::.|      ::...:..:..|.:|:...::..:.:|.::||
Zfish    69 VLPLMVIVFGDMTDSFVD-DTLLDNLKNITLPPNFTFPETSNITLGEKMTTHAIYYSIMGFVVLV 132

  Fly   160 CSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVM 224
            .:|:.:..:..||..|:..:|..||.||:.|::.|:|.|::|::.:|:.:|:.|:.:|:.:|:.|
Zfish   133 AAYMQVAFWTLAAGRQVKKLRKIFFHSIMKQEIGWFDVNETGQLNTRLTDDVYKINEGIGDKLGM 197

  Fly   225 FVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGA 289
            .:..|..|:..:::.|.|||:|:||.|...||..|:..::....:....||.|.||.|..|||..
Zfish   198 LIQNLTTFIVGIIIGFAKGWKLTLVILAVSPLLGISAAVIGKVMTTFTSKEQTAYAKAGAVAEEV 262

  Fly   290 LSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVI 354
            ||.||||.||.|:.||:..|.:.:..||.:.:::.:...|..|..:|.||.|||||||||..|::
Zfish   263 LSSIRTVFAFGGQKKEIKRYHKNLEDAKNVGVRKAITVNIAMGFTFFMIYMSYALAFWYGSTLIL 327

  Fly   355 KGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDG 419
            .|       .|..|.::|:||:|::|:..:|..:|.|:.|..|:||..|||.||:..|:||....
Zfish   328 GG-------EYTIGMLLTIFFAVLIGAFGLGQTSPNIQTFSSARGAAHKVFQIIDHEPKINSFSE 385

  Fly   420 EGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYD 484
            ||.||:.....||||.:.|:||:|.:|.:||.:|||:..|||:||||.|||||||.|||:|||||
Zfish   386 EGYKLDVVKGNIEFKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRFYD 450

  Fly   485 PQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAA 549
            ||.|::..:|.:::.|::..||..||||.|||:||||:|.|||||||:|.|::|||.||..|||.
Zfish   451 PQEGSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREANAY 515

  Fly   550 IFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEK 614
            .||.|||..::||||:||.|:||||||||||||||:|:|:||||||||||||..||..|||||:|
Zfish   516 NFIMKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDK 580

  Fly   615 VSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSP 679
            |..|||||:|||||||:|.||.|.....||:||.|||.||||.|..|.:||..|:          
Zfish   581 VRLGRTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSLVNMQM---------- 635

  Fly   680 TGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDE------KNKKKKKKKVKDPNEVKP------- 731
                :|:.::.:||.||:.:  :::...|...:|      |::...:|::|:  |.||       
Zfish   636 ----FKSTEVAEEDSEEMTM--DEKSPSVSSMNERTLFRQKSRSGSEKELKE--EEKPTEEEKVP 692

  Fly   732 ---MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLY 793
               .|.|:|:|.|||..:.||.:.:.|.|...|.|||:|..|:.:.:..|.: .||:..:.|||.
Zfish   693 NVSFLTVLKLNYPEWPYMVVGILCATINGGMQPAFAVIFSKIIAVFAEPDQN-LVRQRCDLYSLL 756

  Fly   794 FLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAA 858
            |...|::.....|||.:.||.|||.||.|||...|.||:||::||:||..|..|:|..||:.|.|
Zfish   757 FAGIGVLSFFTLFLQGFCFGKAGELLTMRLRFKAFNAMMRQDLAWYDDTKNSVGALTTRLAADTA 821

  Fly   859 AVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAK 923
            .||||||.|:.|:.|:::.|...|.:|..|.|.|.|:.|:..|.:.:|..:|..|:|...:...|
Zfish   822 QVQGATGVRLATLAQNVANLGTAIVISFVYGWQLTLLILSIVPIMAVAGAIQMKLLAGHALKDKK 886

  Fly   924 TMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAY 988
            .:|...|:|.|.:.|:|||.||.||..|...|...||...:.:|:..|..||.:..::::::|||
Zfish   887 ELEQAGKIATEAIENVRTVVSLTRESKFESLYEENLIVPYKNAKKKAHVFGLTFSFSQAMIYFAY 951

  Fly   989 AACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSI 1053
            |.|..:|:|.:..:.:.|..||.|..|::.|..::..|.:|.||..|...:|..:...:.|.|:|
Zfish   952 AGCFKFGSWLIEQKLMTFEGVFLVISAVVYGAMAVGEANSFTPNYAKAKMSASHVLMLINRAPAI 1016

  Fly  1054 VDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLI 1118
            .:.......|...||.|.|:.|.|.||:|.::.||:||:|.|.|||.:||||.|||||||.|||:
Zfish  1017 DNSSEDGDKPDKFEGNVGFEHVYFKYPSRPDVPVLQGLKLRVKKGQTLALVGSSGCGKSTTIQLL 1081

  Fly  1119 QRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISA 1183
            :||||..:|..::|:.|.:.:::..||:|:|||||||:|||.::.|||:||||:|.|..:||:.|
Zfish  1082 ERFYDPQQGRVMLDDNDAKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSREVDQEEIVEA 1146

  Fly  1184 CKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKV 1248
            .|.:|||.||.|||..|.|:.|:||.|||||||||||||||::||||::||||||||||.||||:
Zfish  1147 AKAANIHSFIENLPQRYQTQAGDKGTQLSGGQKQRIAIARAILRNPKVLLLDEATSALDTESEKI 1211

  Fly  1249 VQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQ 1309
            ||||||.||:|||.|.:||||||:.::|.|.|.:||:|.|.|.|:|||:.:|.||||...|
Zfish  1212 VQDALDKASKGRTCIIVAHRLSTIQNADCIAVVQNGVVVEQGTHQQLLSQQGAYYTLVTSQ 1272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 554/1260 (44%)
ABC_membrane 92..382 CDD:279056 94/295 (32%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 152/236 (64%)
ABC_membrane 750..1020 CDD:279056 100/269 (37%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 144/238 (61%)
abcb4NP_001303643.1 PTZ00265 55..1266 CDD:240339 543/1237 (44%)
ABC_membrane 60..348 CDD:279056 94/295 (32%)
ABC_MTABC3_MDL1_MDL2 397..634 CDD:213216 152/236 (64%)
ABC_membrane 714..984 CDD:279056 101/270 (37%)
ABC_MTABC3_MDL1_MDL2 1035..1272 CDD:213216 143/236 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 198 1.000 Domainoid score I3024
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1057 1.000 Inparanoid score I248
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - otm25966
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.910

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