Protein Alignment Mdr50 and abcb4

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001303643.1
• Gene: abcb4 / 100136865
• ZFINID: ZDB-GENE-080204-52
• Length: 1275
• Species: Danio rerio
• Alignment Length: 1296
• Identity: 565/1296 - (43%)
• Similarity: 817/1296 - (63%)
• Gaps: 56/1296 - (4%)

  Fly    43 KSKKK----SKHDESDASDEEDGSQYHED---VKQVSYFQLFRYATKKDRALYVIGLLSAVATGL 100
            |||.|    .|.:..|.|.|::|.:..|:   ::.|...:|||||...|..|.::||:.::|.|.
Zfish     4 KSKLKVSSDKKEENGDVSGEKNGKEEKEEKEKLEMVGPIELFRYADSIDILLMMLGLIMSMANGA 68

  Fly   101 TTPANSLIFGNLANDMIDLGGLLESGK------SYRADDAISTLLLDKVRQFSLQNTYIGIIMLV 159
            ..|...::||::.:..:| ..||::.|      ::...:..:..|.:|:...::..:.:|.::||
Zfish    69 VLPLMVIVFGDMTDSFVD-DTLLDNLKNITLPPNFTFPETSNITLGEKMTTHAIYYSIMGFVVLV 132

  Fly   160 CSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVM 224
            .:|:.:..:..||..|:..:|..||.||:.|::.|:|.|::|::.:|:.:|:.|:.:|:.:|:.|
Zfish   133 AAYMQVAFWTLAAGRQVKKLRKIFFHSIMKQEIGWFDVNETGQLNTRLTDDVYKINEGIGDKLGM 197

  Fly   225 FVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGA 289
            .:..|..|:..:::.|.|||:|:||.|...||..|:..::....:....||.|.||.|..|||..
Zfish   198 LIQNLTTFIVGIIIGFAKGWKLTLVILAVSPLLGISAAVIGKVMTTFTSKEQTAYAKAGAVAEEV 262

  Fly   290 LSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVI 354
            ||.||||.||.|:.||:..|.:.:..||.:.:::.:...|..|..:|.||.|||||||||..|::
Zfish   263 LSSIRTVFAFGGQKKEIKRYHKNLEDAKNVGVRKAITVNIAMGFTFFMIYMSYALAFWYGSTLIL 327

  Fly   355 KGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDG 419
            .|       .|..|.::|:||:|::|:..:|..:|.|:.|..|:||..|||.||:..|:||....
Zfish   328 GG-------EYTIGMLLTIFFAVLIGAFGLGQTSPNIQTFSSARGAAHKVFQIIDHEPKINSFSE 385

  Fly   420 EGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYD 484
            ||.||:.....||||.:.|:||:|.:|.:||.:|||:..|||:||||.|||||||.|||:|||||
Zfish   386 EGYKLDVVKGNIEFKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRFYD 450

  Fly   485 PQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAA 549
            ||.|::..:|.:::.|::..||..||||.|||:||||:|.|||||||:|.|::|||.||..|||.
Zfish   451 PQEGSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREANAY 515

  Fly   550 IFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEK 614
            .||.|||..::||||:||.|:||||||||||||||:|:|:||||||||||||..||..|||||:|
Zfish   516 NFIMKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDK 580

  Fly   615 VSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSP 679
            |..|||||:|||||||:|.||.|.....||:||.|||.||||.|..|.:||..|:
Zfish   581 VRLGRTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSLVNMQM---------- 635

  Fly   680 TGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDE------KNKKKKKKKVKDPNEVKP------- 731
                :|:.::.:||.||:.:  :::...|...:|      |::...:|::|:  |.||
Zfish   636 ----FKSTEVAEEDSEEMTM--DEKSPSVSSMNERTLFRQKSRSGSEKELKE--EEKPTEEEKVP 692

  Fly   732 ---MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLY 793
               .|.|:|:|.|||..:.||.:.:.|.|...|.|||:|..|:.:.:..|.: .||:..:.|||.
Zfish   693 NVSFLTVLKLNYPEWPYMVVGILCATINGGMQPAFAVIFSKIIAVFAEPDQN-LVRQRCDLYSLL 756

  Fly   794 FLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAA 858
            |...|::.....|||.:.||.|||.||.|||...|.||:||::||:||..|..|:|..||:.|.|
Zfish   757 FAGIGVLSFFTLFLQGFCFGKAGELLTMRLRFKAFNAMMRQDLAWYDDTKNSVGALTTRLAADTA 821

  Fly   859 AVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAK 923
            .||||||.|:.|:.|:::.|...|.:|..|.|.|.|:.|:..|.:.:|..:|..|:|...:...|
Zfish   822 QVQGATGVRLATLAQNVANLGTAIVISFVYGWQLTLLILSIVPIMAVAGAIQMKLLAGHALKDKK 886

  Fly   924 TMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAY 988
            .:|...|:|.|.:.|:|||.||.||..|...|...||...:.:|:..|..||.:..::::::|||
Zfish   887 ELEQAGKIATEAIENVRTVVSLTRESKFESLYEENLIVPYKNAKKKAHVFGLTFSFSQAMIYFAY 951

  Fly   989 AACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSI 1053
            |.|..:|:|.:..:.:.|..||.|..|::.|..::..|.:|.||..|...:|..:...:.|.|:|
Zfish   952 AGCFKFGSWLIEQKLMTFEGVFLVISAVVYGAMAVGEANSFTPNYAKAKMSASHVLMLINRAPAI 1016

  Fly  1054 VDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLI 1118
            .:.......|...||.|.|:.|.|.||:|.::.||:||:|.|.|||.:||||.|||||||.|||:
Zfish  1017 DNSSEDGDKPDKFEGNVGFEHVYFKYPSRPDVPVLQGLKLRVKKGQTLALVGSSGCGKSTTIQLL 1081

  Fly  1119 QRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISA 1183
            :||||..:|..::|:.|.:.:::..||:|:|||||||:|||.::.|||:||||:|.|..:||:.|
Zfish  1082 ERFYDPQQGRVMLDDNDAKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSREVDQEEIVEA 1146

  Fly  1184 CKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKV 1248
            .|.:|||.||.|||..|.|:.|:||.|||||||||||||||::||||::||||||||||.||||:
Zfish  1147 AKAANIHSFIENLPQRYQTQAGDKGTQLSGGQKQRIAIARAILRNPKVLLLDEATSALDTESEKI 1211

  Fly  1249 VQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQ 1309
            ||||||.||:|||.|.:||||||:.::|.|.|.:||:|.|.|.|:|||:.:|.||||...|
Zfish  1212 VQDALDKASKGRTCIIVAHRLSTIQNADCIAVVQNGVVVEQGTHQQLLSQQGAYYTLVTSQ 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	554/1260 (44%)
abcb4	NP_001303643.1	PTZ00265	55..1266	CDD:240339	543/1237 (44%)
		MdlB	55..635	CDD:440747	267/587 (45%)