DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr50 and abcb10

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	XP_001343218.3	Gene:	abcb10 / 100003744	ZFINID:	ZDB-GENE-040525-2	Length:	710	Species:	Danio rerio

Alignment Length:	631	Identity:	215/631 - (34%)
Similarity:	333/631 - (52%)	Gaps:	61/631 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 MVTDEKNKKKKKKKVKDPNE-VKPMLEVMKMNKPEW-LQIAVG--CISSVIMGCAMPIFAVLFGS 769
            :|..|.:.|.....:..|:| ||.:|::  .:...| |..|||  .|||.:...| |.|   .|.
Zfish   100 VVNQESSAKTTADSLPVPSEDVKKLLQL--AHPQRWRLTAAVGFLVISSTVTMSA-PFF---LGK 158

  Fly   770 ILQILSVKDNDQYVRENSNQYSLYFLIAGIVV--GIATFLQIYFFGIAGERLTERLRGLMFEAML 832
            ::..:.....:.:   :|:..||..::.|:.:  |.|...::|...|:|:::..:||..:|.::|
Zfish   159 VIDTIYTSPTEDF---SSSLTSLCLMLTGVFLCGGAANAARVYLMQISGQQIVRKLRESLFSSIL 220

  Fly   833 RQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSL-GLVA 896
            :||:.:||  ...||.|..|||.|.|.|.......:...::|::....|:.:.:|...|| ..|.
Zfish   221 KQELGFFD--KTRTGELINRLSADTAIVGRCLTDNLSDGLRSLAQAGAGVGMMLYVSPSLAAFVL 283

  Fly   897 LAFTPFILIAFYMQRTLMAKENMGSAKTME---NCTKLAVEVVSNIRTVASLGREEMFHQNYIGM 958
            :...|...:|....|.|.:.    |.:|.:   ..|:||.|.:||:|||.:.|:|....|.|...
Zfish   284 MVVPPIACLAVIFGRFLRSI----SRRTQDALAEATQLAEERISNLRTVRAFGKELTEVQKYSQK 344

  Fly   959 LIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYG----TWCVIHRGILF-GDVFKVSQALIM 1018
            :....|::|:.                 |..:..:||    :..||...:|: |.:...|:|:.:
Zfish   345 VDHIFELAKKE-----------------AVVSAGFYGVTGLSGNVIILSVLYKGGLLMASEAMTV 392

  Fly  1019 GT------------ASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVR 1071
            |.            .|||...:|...:.||:.|...::..:.|:|......|:.......:|.:.
Zfish   393 GQLSSFLMYAFWVGISIAGFSSFYSELMKGLGAGTRLWELIDRKPEFPLNEGLVLTSELLKGELE 457

  Fly  1072 FDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDV 1136
            |..|.|:||||.:..:.:.|.|.|..|..:|:||.||.|||:.:.|:.|.||.|.|...:|..|:
Zfish   458 FRNVSFAYPTRKDSPIFQDLSLHVPAGSVLAVVGSSGSGKSSLVSLLLRLYDPDSGIVSVDGHDI 522

  Fly  1137 RNVSMTNLRNQLGIVSQEPILFDRTIRENISYG-DNARNVTDQEIISACKKSNIHEFIANLPLGY 1200
            |:::...||:.:|.|||||:||..:|.|||:|| .:...||.::|..|.:.:|.|:||...|.||
Zfish   523 RDLNPYWLRSHIGTVSQEPVLFSCSIAENIAYGAPDPSQVTVEDIYRAAQIANAHDFIQEFPKGY 587

  Fly  1201 DTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISI 1265
            ||.:||||..||||||||:||||||::||||:||||||||||||:|.:||:||:...:|||.:.|
Zfish   588 DTVVGEKGVLLSGGQKQRVAIARALLKNPKILLLDEATSALDAENEFLVQEALERLMDGRTVLII 652

  Fly  1266 AHRLSTVVHSDVIFVFENGLVCEAGDHKQLLAN-RGLYYTLYKLQS 1310
            ||||||:..:|.:.|.:...|.|.|.|.||||| :||:..|.:.|:
Zfish   653 AHRLSTIQSADSVAVLDQHRVMEIGSHSQLLANDQGLFRKLMEKQA 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	214/627 (34%)
		ABC_membrane	92..382	CDD:279056
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216
		ABC_membrane	750..1020	CDD:279056	69/280 (25%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	120/240 (50%)
abcb10	XP_001343218.3	MsbA_rel	123..697	CDD:131259	207/605 (34%)
		ABC_membrane	141..402	CDD:279056	70/290 (24%)
		P-loop_NTPase	457..697	CDD:304359	120/239 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810