DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and abcc1

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	1247	Identity:	278/1247 - (22%)
Similarity:	537/1247 - (43%)	Gaps:	182/1247 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 ISTLLLDK------VRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMK 193
            :.||:|.|      |....|:...:|                |.:.:.|.|.:...|:
Zfish   375 LQTLILQKYFHVCFVTGMRLRTAIVG----------------AVYRKALVITNAARRT------- 416

  Fly   194 WYDFNQSGEVASRMNEDLSKMEDGLAE---------KVVMFVHYLVAFVGSLVLAFVKGWQLSLV 249
                :..||:.:.|:.|..:..|.:..         :|::.:::|...:|:.|||.|      .|
Zfish   417 ----STVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGASVLAGV------AV 471

  Fly   250 CLTSLPL-TFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERV 313
            .:..:|| ..|||.......:::..|:     ....:....|:||:.:|.:..|    .|:|.:|
Zfish   472 MVLMVPLNAVIAMKTKTYQVAQMKSKD-----NRIKLMNEVLNGIKVLKLYAWE----LAFKGKV 527

  Fly   314 VA---AKILNIKRNMFSGIGFGLLWFFIYASYALAF-WYGVGLVIKGYHEPAYEN--YDA--GTM 370
            .|   :::..:|:..:.|......|  :.|.:.:|. .:.|.:::.       ||  .||  ..:
Zfish   528 SAIRESELRVLKKMAYLGAISTFTW--VCAPFLVALSTFAVYVLVD-------ENNILDAQKAFV 583

  Fly   371 ITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKE 435
            ....|:::...:|:   .|.:.:..:......:...:.....|::..:.|...::....:|...:
Zfish   584 SLALFNILRFPLNM---LPMVISSMVQASVSMQRLRVFLSHEELDDDNVERPAISGTPDSIRIAD 645

  Fly   436 VEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDL 500
            ..|.: ::.:...|.::|:.|..|..||:||..|.|||:.:..:......|.|::...|:
Zfish   646 GAFSW-SKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSVSIKGS----- 704

  Fly   501 DINWLRSRIGVVGQEPILFATSIYENIRYGREDATREE-----IEAAAAAANAAIFIKKLPKGYD 560
                    :..|.|:..:...::.:||.:|||  |::.     :||.|...:..|    ||.|..
Zfish   705 --------VAYVPQQAWIQNATLKDNILFGRE--TKDSWYQKVVEACALLPDLEI----LPGGDT 755

  Fly   561 TLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSA------GR 619
            |.:||:|..||||||||:::|||:..:..:.|||:..||:|......:   .|||..      ||
Zfish   756 TEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHI---FEKVIGPQGLLQGR 817

  Fly   620 TTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIY 684
            |.::|.|.||.:.:||.|:|:..||:.|.|::.||:..:..:...:.|....:........||..
Zfish   818 TRVLVTHGLSFLPQADLILVMVDGEITEMGSYTELLGRQGAFAEFLRTYTNTEQEEGEESLGDAV 882

  Fly   685 KNFDIKDED------EEEIKVLSEDEDEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEW 743
            ....:::..      :.:|.:.:....:....| |.|......|.|.. |...:.|..|.|...
Zfish   883 PRKGLENGGPAALLRQSQISLNATGAGKTTQKT-EANDDAAATKTKSA-EASRLTEADKANTGR- 944

  Fly   744 LQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDN-------DQYVRENSN-----QYSLYFLI 796
            ::::|.......:|..:.||::.......:.|:..|       |..|..|:.     :..:|..:
Zfish   945 VKLSVFWEYMKAIGLPLSIFSIFLFFCHHLSSLGSNYWLSLWTDDPVVNNTQPKREMRLGVYGAL 1009

  Fly   797 AGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQ 861
             ||..|||.|.......:.|...:..|...|...:||..:::|:  ...:|:|..|.:.:.
Zfish  1010 -GISQGIAVFCYSVSVSVGGILASRYLHQTMLYNVLRSPMSFFE--RTPSGNLVNRFAKET---- 1067

  Fly   862 GATGQRIGTIVQSISTLALGIALSMYYEWSLG----------LVALAFTPFILIAFYMQRTLMAK 916
                ..|.:::.||..:.:|...::     ||          |||:...|..|:.|::||..:|.
Zfish  1068 ----DTIDSVIPSIIKMFMGSMFNV-----LGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVAS 1123

  Fly   917 ENMGSAKTMENCTKLAV-----EVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLV 976
            ..  ..|.:|:.::..|     |.:.....:.:.|.::.|.:...|.:     ...:..:|..:|
Zfish  1124 SR--QMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRV-----DHNQKAYFPSIV 1181

  Fly   977 YG--LARSLMFFAYAACMYYGTWCVIHRGILFGDV--FKVSQALIMGTASIANALAFAPNMQKGV 1037
            ..  ||..|.|.......:...:.|:.|..|...:  ..:|.||.: |||:...:..:..::..:
Zfish  1182 ANRWLAVRLEFVGNCIVTFAALFAVMARNNLSPGIMGLSISYALQV-TASLNWLVRMSSELETNI 1245

  Fly  1038 SAAKTIFTFLRRQPSIVDRPGVSRDP--WHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQK 1100
            .|.:.:..:...:.....:...|..|  |.:.|::...|....|....|:.:. .:.:.::.|:|
Zfish  1246 VAVERVKEYGDTEKEAEWKLENSNLPPGWPTAGHIEIHKFGLRYREDLELAIC-DISVNIAGGEK 1309

  Fly  1101 IALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIREN 1165
            :.:||.:|.|||:....:.|..:..||...||..::.::.:..||:::.|:.|:|:||..::|.|
Zfish  1310 VGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRMN 1374

  Fly  1166 ISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPK 1230
            :   |.....||:|:..:.:.:::..|::.||...:....|.|..||.||:|.:.:||||:|..|
Zfish  1375 L---DPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTK 1436

  Fly  1231 IMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQL 1295
            |::|||||:|:|.|::.::|..:....|..|.::|||||:|::....:.|.:.|.:.|......|
Zfish  1437 ILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNL 1501

  Fly  1296 LANRGLYYTLYK 1307
            :|.:|::|.:.|
Zfish  1502 IAKKGIFYKMAK 1513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	278/1247 (22%)
		ABC_membrane	92..382	CDD:279056	50/270 (19%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	73/247 (30%)
		ABC_membrane	750..1020	CDD:279056	58/300 (19%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	71/238 (30%)
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	278/1247 (22%)
		ABC_membrane	331..595	CDD:279056	50/270 (19%)
		ABCC_MRP_domain1	641..842	CDD:213217	67/223 (30%)
		ABC_membrane	966..1231	CDD:279056	57/288 (20%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	67/223 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000