Protein Alignment SmydA-1 and SMYD1

DIOPT Version :10

• Sequence 1: NP_610944.1
• Gene: SmydA-1 / 36581
• FlyBaseID: FBgn0033917
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_938015.1
• Gene: SMYD1 / 150572
• HGNCID: 20986
• Length: 490
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 83/450 - (18%)
• Similarity: 149/450 - (33%)
• Gaps: 137/450 - (30%)

  Fly     4 CHVC--EEPTKNKCSNCNQVSYCSVQHQKQDWKVHKPSCHPFKIAHNEQLGRHLVATRTIKPYEI 66
            ||.|  .:...::|..|....||....||..|..||..|...|     :.|:        .|.|.
Human    52 CHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIK-----RYGK--------VPNEN 103

  Fly    67 VLKEAPLVRGPAQISAPVCLGCLNGIEAEDHIECEQCGWPLCGPECKSLDEHKAECGLTKDRGQK 131
            :...|.::....:....:..|||..::                    .|..|
Human   104 IRLAARIMWRVEREGTGLTEGCLVSVD--------------------DLQNH------------- 135

  Fly   132 VNVQEFGGPHPLYTCLSTVRCLLIGETSTEKASKFQDLESLESTRRGSNQWKADLVSIGQFIPKF 196
              |:.||                      |:..|  ||             :.|:.:..|:.|.
Human   136 --VEHFG----------------------EEEQK--DL-------------RVDVDTFLQYWPP- 160

  Fly   197 FKTQKFTEEEIMKAVGALQINGHEVPT---TDPSHVAVFYTASFTENSCLPNLAKSFNKNGH--- 255
             ::|:|:.:.|....|.:..||..:..   .....|.:|.......:.|.||....||...|
Human   161 -QSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAV 224

  Fly   256 ---------CILWAPREIKKNAHLSICYSDAMWGTADRQRHLMQTKLFKCACERCVDVTELDTNY 311
                     ..|.|..:|.:...|::.|.|.:..:.:|:|.|.:...|.|.||.|..
Human   225 KSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQK-------- 281

  Fly   312 SAIKCEDRQCGGLMLPTKADEWNGSWRCRECHKQVQKHYVERILERAGKDIQSMEKIAENGL--K 374
               |.:|    .|.|..|.            :.:..:..|:.:::.:...::.::|....||  :
Human   282 ---KLKD----DLFLGVKD------------NPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHE 327

  Fly   375 YLKHYEKWLPPQHFHMSEIKILLVQLLAKDQKELMVIPDDRLLLKLNF-ARELVELYEKL 433
            .:|...:.|..|....::..|.::::|:...:.|..:   :...:.:| ||.:|:.|.||
Human   328 VVKLCRECLEKQEPVFADTNIYMLRMLSIVSEVLSYL---QAFEEASFYARRMVDGYMKL 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-1	NP_610944.1	zf-MYND	4..40	CDD:460312	12/37 (32%)
		SET_SMYD	<217..301	CDD:380997	23/98 (23%)
SMYD1	NP_938015.1	SET_SMYD1	7..281	CDD:380924	61/315 (19%)
		zf-MYND	52..90	CDD:460312	12/37 (32%)