DRSC/TRiP Functional Genomics Resources

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Protein Alignment SmydA-1 and SMYD4

DIOPT Version :10

Sequence 1:NP_610944.1 Gene:SmydA-1 / 36581 FlyBaseID:FBgn0033917 Length:513 Species:Drosophila melanogaster
Sequence 2:NP_443160.2 Gene:SMYD4 / 114826 HGNCID:21067 Length:804 Species:Homo sapiens


Alignment Length:465 Identity:102/465 - (21%)
Similarity:152/465 - (32%) Gaps:158/465 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 NEQL---------------GRHLVATRTIKPYEIVLKEAPLVR--GPAQISAP------------ 83
            ||||               ||.||||:.|.|.|::::|...|.  .|.::..|            
Human   225 NEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRV 289

  Fly    84 -----VCLGCLNGIEAEDHIECEQCGW-PLCGPECKSLDE-----HKAEC---GLTKDRGQKVNV 134
                 .|..||....|.  :.|:.|.: ..|..||  |.:     |:.||   ||....|...::
Human   290 TNGDLYCHRCLKHTLAT--VPCDGCSYAKYCSQEC--LQQAWELYHRTECPLGGLLLTLGVFCHI 350

  Fly   135 Q-------EFGGPHPLYT-----------CL----STVRCLLIGETSTEK--------------A 163
            .       .|.....:.|           ||    :.|:.|..|...:||              .
Human   351 ALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDIN 415

  Fly   164 SKFQD-----LESLESTRRGSNQWK-------------ADLVSIGQFIPKFFKTQKFTEEEIMKA 210
            .|:::     ...|..|...|.:.|             .:..|: |.||    |::......:||
Human   416 GKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASL-QAIP----TERIVNSSQLKA 475

  Fly   211 VGA--------------------LQINGHEVPT-----------TDPSHV----AVFYTASFTEN 240
            ...                    ||.|...:.|           ||...|    .:|...|...:
Human   476 AVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNH 540

  Fly   241 SCLPNLAKSFNKNGHCILWAPREIKKNAHLSICYS--DAMWGTADRQRHLMQTKLFKCACERCVD 303
            ||.||.:.||......|. |.:.|:|...:..||.  .:..|.|:||:.|.....|.|||..|  
Human   541 SCSPNTSVSFISTVATIR-ASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC-- 602

  Fly   304 VTELDTNYSAIKCEDRQCGGLMLPTKADEWNGSWRC--RECHKQV--QKHYVERILERAGKDIQS 364
            .||.....:..:.|...|.....|.:.|:   ..||  |.|.:..  :.|.|.|:     :|:|.
Human   603 QTEAHRMAAGPRWEAFCCNSCGAPMQGDD---VLRCGSRSCAESAVSRDHLVSRL-----QDLQQ 659

  Fly   365 MEKIAENGLK 374
            ..::|:..|:
Human   660 QVRVAQKLLR 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmydA-1NP_610944.1 zf-MYND 4..40 CDD:460312
SET_SMYD <217..301 CDD:380997 28/100 (28%)
SMYD4NP_443160.2 NlpI <66..>171 CDD:443815
TPR repeat 68..96 CDD:276809
TPR repeat 101..135 CDD:276809
TPR repeat 143..171 CDD:276809
SET 239..>269 CDD:394802 11/29 (38%)
zf-MYND 296..335 CDD:460312 11/42 (26%)
SET_SMYD4 404..602 CDD:380934 42/203 (21%)
TPR_12 660..726 CDD:315987 2/10 (20%)
TPR_12 698..771 CDD:315987
Blue background indicates that the domain is not in the aligned region.

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