Protein Alignment Usp20-33 and USP6

DIOPT Version :9

• Sequence 1: NP_610943.2
• Gene: Usp20-33 / 36580
• FlyBaseID: FBgn0033916
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001291213.1
• Gene: USP6 / 9098
• HGNCID: 12629
• Length: 1406
• Species: Homo sapiens
• Alignment Length: 1045
• Identity: 215/1045 - (20%)
• Similarity: 340/1045 - (32%)
• Gaps: 387/1045 - (37%)

  Fly    60 DSNASDSEGTDTAKGSGTGLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIAEQSAR 124
            :|:..|.:...|.||:    .||.|:.|||:|||::|.:||..|:|.|||:...|.|      ..
Human   516 NSSKIDRQKVPTEKGA----TGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYE------LN 570

  Fly   125 RCKP----GGLAKSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFM 185
            |..|    |.:||.|..|:||:|...   ::.:||..:...|....|.|.|:||.|:||.|...:
Human   571 RTNPIGMKGHMAKCYGDLVQELWSGT---QKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLL 632

  Fly   186 DQLHEELTEQVSMLPQTQNQPQYQSLQQQQPSETDDENDDEAAPASLSHASESEYDTCESSMSER 250
            |.|||:|.       :...:| |..|:     ::|...|.|.|..:..:
Human   633 DGLHEDLN-------RVHEKP-YVELK-----DSDGRPDWEVAAEAWDN---------------- 668

  Fly   251 SAEVLLKTEYFVTPCRTNGSNSGLPEGHSVQLQQAPLQHQQKNASSAEQKPIEAARSIISDVFDG 315
                                                  |.::|            ||||.|:|.|
Human   669 --------------------------------------HLRRN------------RSIIVDLFHG 683

  Fly   316 KLLSSVQCLTCDRVSTREETFQDLSLPIPNRDFLNVLHQTHSLSVQSLNAAETSARTNEGWLSWM 380
            :|.|.|:|.||..:|.|.:.|..||||:|...::::     .::|..|:.. |..|
Human   684 QLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDL-----EITVIKLDGT-TPVR--------- 733

  Fly   381 WNMLRSWIYGPSVTLYDCMASFFSADELKGDNMYSCERCNKLRTGIK---------YSRVLTLPE 436
                    ||..:.:               |..|         ||:|         .|..:.|.|
Human   734 --------YGLRLNM---------------DEKY---------TGLKKQLRDLCGLNSEQILLAE 766

  Fly   437 VLCIHLKRFRND-------------------------------LSYSSKISSDVYFPLEGFDMRP 470
            |...::|.|..|                               :.:||..|::..|.|.
Human   767 VHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFTLT------ 825

  Fly   471 YIHKDCKSEVAIYN-LSSVICHHGTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELVQSCQAY 534
             .:.|....:.|.| :.:.:...||...     |....:||......|...|           .|
Human   826 -TNGDLPKPIFIPNGMPNTVVPCGTEKN-----FTNGMVNGHMPSLPDSPFT-----------GY 873

  Fly   535 VLFYHKHNPQMKLVRDEAMTLSTSH--------PL---C-------DSDIQFYITREWLSRLATF 581
            ::..|:     |::|.|...||...        ||   |       |.....:|...||:|
Human   874 IIAVHR-----KMMRTELYFLSPQENRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSWLAR---- 929

  Fly   582 SEPGPINNQEMLCPHGGILHSK-ADVISQIAVPISQPL---------WDYLY------------- 623
              |.|        |....:|:: .|.......|.:..:         |...|
Human   930 --PLP--------PQEASIHAQDRDNCMGYQYPFTLRVVQKDGNSCAWCPQYRFCRGCKIDCGED 984

  Fly   624 RTFGGGPAVNIIF-------------ECEICKRAAETLSRRQQYE-------LNEFTKYNGLQNE 668
            |.|.|...:.:.:             |..:.|..:...|||.|.|       |..||.    :.|
Human   985 RAFIGNAYIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTS----EEE 1045

  Fly   669 FDSTAIYAIAMPWLRSWQQFSRGKTHKDPGPITNEGIAAPTENGSATVSCVRLGSDYAQLNARLW 733
            ...:.:|           ..|:.|||                       |:      |.....||
Human  1046 LGESEMY-----------YCSKCKTH-----------------------CL------ATKKLDLW 1070

  Fly   734 R-------------FLHNIYGGGPEII--LRQA------LSDEDDA--EEIEIIDQDDECDDDED 775
            |             |:::.:....:|:  ||::      |...|.|  :...:..|.||......
Human  1071 RLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAFLVPRDPALCQHKPLTPQGDELSKPRI 1135

  Fly   776 QDLEGEGEDEEIAAASYQHNHSDTESNL--GIRNTPSPSPSTSPSPSLTGTRQPMETESDLRPSS 838
            ...|.:..|.:.:|.......|.:.|:|  .|.::|..|||:|..   :||..|....|.  |:|
Human  1136 LAREVKKVDAQSSAGKEDMLLSKSPSSLSANISSSPKGSPSSSRK---SGTSCPSSKNSS--PNS 1195

  Fly   839 SKSKRSRSKMKVSALRLNMRNR---GKRNRSAFK-----QYAEMFGA--KGNYNAHSNAEPVVSE 893
            |.....|||.::...::..:|:   .|:|..|.|     |..|:..|  :|:....|..|.|.
Human  1196 SPRTLGRSKGRLRLPQIGSKNKPSSSKKNLDASKENGAGQICELADALSRGHMRGGSQPELVT-- 1258

  Fly   894 KDEKDKDNDRTVAFPSEYSLPISIPFQSDNFQVNGVHEKSRDKGKLRNSSKSGSTAATKENVTLQ 958
                          |.::.:.::..|..::.............|:|.|.|:..||...:|:..::
Human  1259 --------------PQDHEVALANGFLYEHEACGNGCGDGYSNGQLGNHSEEDSTDDQREDTHIK 1309

  Fly   959 KFVTL 963
            ....|
Human  1310 PIYNL 1314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	110/503 (22%)
		Peptidase_C19	80..>204	CDD:271592	46/127 (36%)
		Peptidase_C19R	307..538	CDD:239139	54/271 (20%)
		DUSP	560..643	CDD:197831	20/128 (16%)
		DUSP	667..755	CDD:197831	16/108 (15%)
USP6	NP_001291213.1	TBC	97..312	CDD:214540
		DUF4607	<332..407	CDD:292024
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..380
		UBP12	<528..1114	CDD:227847	163/810 (20%)
		Peptidase_C19	533..>723	CDD:271592	76/282 (27%)
		Peptidase_C19	<1023..1367	CDD:271592	73/357 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1120..1231		30/115 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1384..1406

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900