Protein Alignment Usp20-33 and UBP12

DIOPT Version :10

• Sequence 1: NP_610943.2
• Gene: Usp20-33 / 36580
• FlyBaseID: FBgn0033916
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_012338.1
• Gene: UBP12 / 853242
• SGDID: S000003733
• Length: 1254
• Species: Saccharomyces cerevisiae
• Alignment Length: 853
• Identity: 180/853 - (21%)
• Similarity: 274/853 - (32%)
• Gaps: 362/853 - (42%)

  Fly    77 TGLVGLQNIANTCYMNSALQALSNLPPMTHYF--------INCSDLVEYIAEQSARRCKPGGLAK 133
            :|..||.|:.||||||||||.|.::|.:..||        ||..:.:.|          .|.:|:
Yeast   361 SGTTGLVNLGNTCYMNSALQCLVHIPQLRDYFLYDGYEDEINEENPLGY----------HGYVAR 415

  Fly   134 SYRRLMQEIWQD---VDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEEL--- 192
            ::..|:|:::|:   :........|......|...:.||.||.|.|:||||...:|.|||:|
Yeast   416 AFSDLVQKLFQNRMSIMQRNAAFPPSMFKSTIGHFNSMFSGYMQQDSQEFLAFLLDSLHEDLNRI 480

  Fly   193 -----TEQVSMLP--------------------------------------QTQNQPQYQSLQQQ 214
                 ||:.|:.|                                      .|...|:.|::
Yeast   481 IKKEYTEKPSLSPGDDVNDWNVVKKLADDTWEMHLKRNCSVITDLFVGMYKSTLYCPECQNV--- 542

  Fly   215 QPSETDDENDDEAAP------------------------ASLSHASE------------------ 237
              |.|.|..:|...|                        ..||.:|.
Yeast   543 --SITFDPYNDVTLPLPVDTVWDKTIKIFPMNSPPLLLEVELSKSSTYMDLKNYVGKMSGLDPNT 605

  Fly   238 ------------SEYDTCESSMSERSAEVLLK--------------------------------- 257
                        ..|::.||:....:.:.|:|
Yeast   606 LFGCEIFSNQIYVNYESTESNAQFLTLQELIKPADDVIFYELPVTNDNEVIVPVLNTRIEKGYKN 670

  Fly   258 -----TEYFVTPCRTNGSNSGL---------------------PEGHSVQLQQA-PLQHQQKNAS 295
                 ..:|:|......:|.|.                     |.|:......| ||..::....
Yeast   671 AMLFGVPFFITLKEDELNNPGAIRMKLQNRFVHLSGGYIPFPEPVGNRTDFADAFPLLVEKYPDV 735

  Fly   296 SAEQ-KPIEAARSI-ISD----VFDGKLLS-------------------SVQCLTCDRVSTREET 335
            ..|| |.|....|| ::|    .|..|:||                   .:..|..|:.:..::.
Yeast   736 EFEQYKDILQYTSIKVTDKDKSFFSIKILSVEKEQQFASNNRTGPNFWTPISQLNLDKATDIDDK 800

  Fly   336 FQDLSLPIPNRDFL-----NVLHQ-------------------------------THSLSVQSLN 364
            .:|:...|.|...|     .||.|                               |::.:|.:.|
Yeast   801 LEDVVKDIYNYSSLVDCAEGVLMQVDDEGDTEGSEAKNFSKPFQSGDDEENKETVTNNENVNNTN 865

  Fly   365 ----------AAETSART-----------------------------------------NEGWLS 378
                      ..|..|.|                                         ||.:..
Yeast   866 DRDEDMELTDDVEEDASTEPELTDKPEALDKIKDSLTSTPFAILSMNDIIVCEWSELGSNEAFSD 930

  Fly   379 ---WMW--------------NMLRSWIYGPSVTLYDCMASFFSADELKG--DNMYSCERCNKLRT 424
               :.|              .:.||.....::||.||: ..||..|:.|  |:.| |..|.:.|.
Yeast   931 DKIYNWENPATLPNKELENAKLERSNAKERTITLDDCL-QLFSKPEILGLTDSWY-CPTCKEHRQ 993

  Fly   425 GIKYSRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPY-IHKDCKSEVAIYNLSSV 488
            ..|..::...|::|.||||||.:..|:|.||.:.|.||:...|:..| ::|| .....||:|.:|
Yeast   994 ATKQIQLWNTPDILLIHLKRFESQRSFSDKIDATVNFPITDLDLSRYVVYKD-DPRGLIYDLYAV 1057

  Fly   489 ICHHGTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELVQSCQAYVLFY--------------- 538
            ..|:|.:||||||.:.:|..:.|||.|||..|||.:.|...:..||:|||
Yeast  1058 DNHYGGLGGGHYTAYVKNFADNKWYYFDDSRVTETAPENSIAGSAYLLFYIRRHKDGNGLGSSKL 1122

  Fly   539 --------HKHNPQMKLVRDEAMTL------------STSHPLCDSDIQFYITREWLSRLATFSE 583
                    |.::.::|.:.||.|.|            |.....|:.|:|   ..|:.:|..   |
Yeast  1123 QEIIQKSRHGYDERIKKIYDEQMKLYEFNKTDEEEDVSDDMIECNEDVQ---APEYSNRSL---E 1181

  Fly   584 PGPINNQE 591
            .|.|..|:
Yeast  1182 VGHIETQD 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	80..538	CDD:425685	161/760 (21%)
		DUSP	560..643	CDD:197831	9/32 (28%)
		DUSP	667..755	CDD:197831
UBP12	NP_012338.1	UBP12	99..1111	CDD:227847	164/767 (21%)