Protein Alignment Usp20-33 and USP11

DIOPT Version :9

• Sequence 1: NP_610943.2
• Gene: Usp20-33 / 36580
• FlyBaseID: FBgn0033916
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001358001.1
• Gene: USP11 / 8237
• HGNCID: 12609
• Length: 920
• Species: Homo sapiens
• Alignment Length: 793
• Identity: 175/793 - (22%)
• Similarity: 276/793 - (34%)
• Gaps: 283/793 - (35%)

  Fly    14 VEH----RNRTIHSSQGHTLANGYAMGDPR---------SSRCHDKLFSGSLKSL---------- 55
            |.|    ::.|:..|  ||.:.|..:...|         .:|...|...|||..|
Human   159 VRHNDLGKSHTVQFS--HTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDA 221

  Fly    56 -----------ARREDS----------NASDSEGTDTAKGSGTGLVGLQNIANTCYMNSALQALS 99
                       .|::|.          |.:.||..:..||. .|:.||.|:.|||:||||||.||
Human   222 ALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQ-PGICGLTNLGNTCFMNSALQCLS 285

  Fly   100 NLPPMTHYFI-NCSDLVEYIAEQSARRCKP----GGLAKSYRRLMQEIWQDVDDPKEFIAPRGIL 159
            |:|.:|.||: ||     |:.|.:.|  .|    |.:|::|..|:::.|   ......|.|....
Human   286 NVPQLTEYFLNNC-----YLEELNFR--NPLGMKGEIAEAYADLVKQAW---SGHHRSIVPHVFK 340

  Fly   160 YGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTEQVSMLPQTQNQPQYQSLQQQQPSETDDEND 224
            ..:......|.||||||:||.|...:|.|||:|..        ..:.:|..|     .:.....|
Human   341 NKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNR--------VKKKEYVEL-----CDAAGRPD 392

  Fly   225 DEAA-PASLSHASESEYDTCESSMSERSAEVLLKTEY------FVTPCRTNGS---------NSG 273
            .|.| .|..:|             ..|:..|::.|.:      .|.|...|.|         :..
Human   393 QEVAQEAWQNH-------------KRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVP 444

  Fly   274 LPEGHSVQLQ---------QAPLQHQ----QKNASS------AEQKPIEAARSIISDVFDGKL-- 317
            ||..|...|:         :.|.||:    :|...|      ::...|...|.:::|||..:.
Human   445 LPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVADVFSHRFYK 509

  Fly   318 -------LSSVQCLTCD---------RVSTREETFQDLSLPI------PNRDF------------ 348
                   |||:  |..|         |:...|.:.:|:.:|:      |.||:
Human   510 LYQLEEPLSSI--LDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYGLMLFGH 572

  Fly   349 ----------------LNVL--------------------------------------------- 352
                            .|||
Human   573 PLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDDEEDKDDVPGPSTGGSLRDPE 637

  Fly   353 -------------------------------HQTHSLSVQSLNAAETSARTNEG---------WL 377
                                           .:....::|::|:..||.||...         .:
Human   638 PEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQTVNSNGTSDRTTSPEEVHAQPYIAI 702

  Fly   378 SWMWNMLRSW------------------IYGPSVTLYDCMASFFSADELKGDNMYSCERCNKLRT 424
            .|...|.:.:                  :....|.|.:|:..|.:.:.|:.:|.:.|..|.:.:.
Human   703 DWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVRLQECIELFTTVETLEKENPWYCPSCKQHQL 767

  Fly   425 GIKYSRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYI---HKDCKSEVAIYNLS 486
            ..|...:..|||:|.||||||........|:.:.|.||:...|...::   ..:...|:..|:|.
Human   768 ATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLI 832

  Fly   487 SVICHHGTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELVQSCQAYVLFYHKHNPQMKLVRDE 551
            :|..|:|.:..||||.||.|..:|:|:.|||..|:.|:...::|..||||||.:.:...:|:...
Human   833 AVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPA 897

  Fly   552 AMTLSTSHPLCDS 564
            ..:.:.:.|.|.|
Human   898 GSSGAPASPACSS 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	147/656 (22%)
		Peptidase_C19	80..>204	CDD:271592	47/128 (37%)
		Peptidase_C19R	307..538	CDD:239139	75/388 (19%)
		DUSP	560..643	CDD:197831	3/5 (60%)
		DUSP	667..755	CDD:197831
USP11	NP_001358001.1	UBP12	56..886	CDD:227847	171/767 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910