DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp20-33 and Usp45

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_690038.1	Gene:	Usp45 / 77593	MGIID:	101850	Length:	813	Species:	Mus musculus

Alignment Length:	730	Identity:	147/730 - (20%)
Similarity:	248/730 - (33%)	Gaps:	268/730 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 YAMGDPRSSRCHDKLF---------------SGSLKSLARREDSNASDSEGTDTAKGSGTGLV-G 81
            |...:..|:.|:.|:.               :|:...:.:..:......|.....||.....| |
Mouse   128 YECNEKLSTHCNKKVLAQIVDFLQKHAFKTQTGAFSRIIKLCEEKREAGEIKKGKKGCTVPSVKG 192

  Fly    82 LQNIANTCYMNSALQALSNLPPM-----------THYFINCS---DLVEYIAEQSARRCKPGGLA 132
            :.|:.|||:.|:.:|.|:....:           |.:.|:.|   .|...:.|.|:    ||.|.
Mouse   193 ITNLGNTCFFNAVIQNLAQTYILFELMNEIKEDGTKFKISLSSAPQLEPLVVELSS----PGPLT 253

  Fly   133 KSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTE--Q 195
            .:....:..:.:....|   ::|:.:...:....|.|:|:||.|:||.|...:|.:..|.|:  |
Mouse   254 SALFLFLHSMKEAEKGP---LSPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEETKRIQ 315

  Fly   196 VSML-----PQTQ---------------------------------------------------- 203
            .|:|     |.|:
Mouse   316 ASILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFIDRIFIGELTSTVMCEECANISTMKDPFID 380

  Fly   204 ----------NQP-------QYQSLQQ-------------------------------------- 213
                      ::|       :.:|||:
Mouse   381 ISLPIIEERVSKPVLLGKMSKCRSLQETDQDHNKGTVTVGNAHQPRASRKHSSPNDKNQLSHDRK 445

  Fly   214 ---QQPSE------TDDENDD-EAAPASLSHASESEYDTCESSMSERSA---------------E 253
               :.|||      |..:||: ||:|.:.:.::|:..:...:..|||.|               |
Mouse   446 HLRKWPSEEEKTVVTHPKNDNLEASPPASTLSTEASLNESLTDGSERDASLESSVDADSEASEPE 510

  Fly   254 VLLKTEYFVTPCRTNGSNSGLPEGHSVQLQQAPLQH---QQKNASSAEQKPIEAARSIISDVFDG 315
            :..|....:   |:.|.:.    ||:.|....||..   |.|.....|::..||    |:::.
Mouse   511 IASKQPVLL---RSRGDSC----GHAEQHPHLPLASELPQAKETHGGEEEMAEA----IAELH-- 562

  Fly   316 KLLSSVQCLTCDRVSTREETFQDLSLPIPNRDFLNVLH-QTHSLSVQSLNAAETSARTNEGWLSW 379
              ||..  :|.:|...||:  |.|::| .|..|....| :.||    :.||.:|
Mouse   563 --LSGT--VTGNRDFHREK--QPLNVP-NNLCFSEGKHTRLHS----AQNAFQT----------- 605

  Fly   380 MWNMLRSWI-YGPSVTLYDCMASFFSADELKGDNMYSCERCNKLRT--------------GI--- 426
               :.:|:: .....::..|:..|.|.:.|.|:|...||.|.:.|.              |:
Mouse   606 ---LSQSYVTTSKECSVQSCLYQFTSMELLMGNNKLLCEDCTEKRRKCHKETSSAEKKAGGVYTN 667

  Fly   427 --KYSRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHKDCKS----EVAIYNL 485
              |...:..:|.:|.:|||||........|::..|.|||. .|:.|:....||:    |..:|.|
Mouse   668 ARKQLLISAVPAILILHLKRFHQAGLSLRKVNRHVDFPLT-LDLAPFCAATCKNISVGEKVLYGL 731

  Fly   486 SSVICHHGTVGGGHYTCFAR-------------------------NTLNGKWYEFDDQFVTEVSS 525
            ..::.|.|::.|||||.:.:                         ..|.|.|....|.:|..|..
Mouse   732 YGIVEHSGSMRGGHYTAYVKVRVPSRKLSECITGRKTAAGLKEPDGELGGHWVHVSDTYVQVVPE 796

  Fly   526 ELVQSCQAYVLFYHK 540
            ....|.|||:|||.:
Mouse   797 SRALSAQAYLLFYER 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	137/665 (21%)
		Peptidase_C19	80..>204	CDD:271592	37/207 (18%)
		Peptidase_C19R	307..538	CDD:239139	68/280 (24%)
		DUSP	560..643	CDD:197831
		DUSP	667..755	CDD:197831
Usp45	NP_690038.1	Interaction with ERCC1. /evidence=ECO:0000305\|PubMed:25538220	1..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		UBP14	<72..>359	CDD:227532	45/237 (19%)
		Peptidase_C19	192..>388	CDD:351799	36/202 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..552		27/153 (18%)
		Peptidase_C19K	<587..810	CDD:239132	58/241 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900