DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp20-33 and Ggnbp1

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_081820.2	Gene:	Ggnbp1 / 70772	MGIID:	3055306	Length:	370	Species:	Mus musculus

Alignment Length:	331	Identity:	55/331 - (16%)
Similarity:	94/331 - (28%)	Gaps:	149/331 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   528 VQSCQAYVLFYHKHNPQMKLVRDEAMTLSTSHPLCDSDIQFYITREWLSRLATFSEPGPINNQEM 592
            :..|.:.:.|..      .||..:..:.||:.||                  |.|:|.....|::
Mouse    12 ILGCSSMLRFLR------NLVGSKGGSKSTNKPL------------------TRSQPSSSWEQDV 52

  Fly   593 LCP----HGG--------ILHSKAD----------VISQIAVPISQPLWDYLYRTFGGGPAVNII 635
            :.|    .||        .:||.|.          |:|  |.| |.|..|              .
Mouse    53 VSPMMGHQGGRGRKEPRAKVHSAASSNGKREPPPRVLS--AAP-SNPRHD--------------A 100

  Fly   636 FECEICKRAAETLSRRQQYELNEFTKYNGLQNEFDSTAIYAIAMPWLRSWQQFSR---------- 690
            ||.......::||:.:...:|.             :..:...::|...:|:...:
Mouse   101 FELGTGDSGSQTLTSKDVPKLR-------------AQGVEVTSVPLRGTWEVLEQLPEKKGEEEE 152

  Fly   691 ------GKTHKD----------------PGPIT---------NEGIAAPTENGSATVSCVRLGSD 724
                  |.:.::                |||:.         .|....|.|.|....|..::||
Mouse   153 PVGEVSGASDREHFGQALETEQGCLQWVPGPLALTPGAFIKEEEDEHCPIEFGDLKPSSCKVGS- 216

  Fly   725 YAQLNARLWRFLHNIY-------------GGGPEIILRQALSDEDDAEEIEIIDQ---------- 766
                  ..|.:|..:|             ...|::.|:..|..|:..|..|.:|:
Mouse   217 ------TPWNYLLGLYKQLQKSAMAKAQRPAAPQLALKDGLPHEEKGEREEAVDESCPKWCAPRA 275

  Fly   767 --DDEC 770
              |:.|
Mouse   276 SSDESC 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	1/9 (11%)
		Peptidase_C19	80..>204	CDD:271592
		Peptidase_C19R	307..538	CDD:239139	1/9 (11%)
		DUSP	560..643	CDD:197831	21/104 (20%)
		DUSP	667..755	CDD:197831	19/141 (13%)
Ggnbp1	NP_081820.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..114		25/122 (20%)
		Required for induction of mitochondrial fragmentation	225..370		10/57 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..263		6/22 (27%)
		Ubiquitin_3	281..368	CDD:291502	1/1 (100%)
		Interaction with GGN	298..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900