DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp20-33 and usp11

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_002663119.3	Gene:	usp11 / 568334	ZFINID:	ZDB-GENE-081104-421	Length:	990	Species:	Danio rerio

Alignment Length:	778	Identity:	163/778 - (20%)
Similarity:	263/778 - (33%)	Gaps:	298/778 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 NASDSEGTDTAKGSGTGLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIAEQSARRC 126
            |::|.   |:.:|. .|:.||.|:.|||:||||||.|||.||:|.||:  .:|  |:.|.:.  .
Zfish   228 NSADE---DSYRGP-PGVCGLTNLGNTCFMNSALQCLSNTPPLTEYFL--KNL--YLEELNF--S 282

  Fly   127 KP----GGLAKSYRRLMQEIWQDVDDPKEF-IAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMD 186
            .|    |.:|::|..:::::|..    :.: :.||.....:......|.||||||:||.|...:|
Zfish   283 NPLGMKGEIAEAYADVIKQMWSG----RHYSVVPRVFKTKVGHFASQFLGYQQHDSQELLSFLLD 343

  Fly   187 QLHEELT------------------------------------------------------EQVS 197
            .|||:|.                                                      .:||
Zfish   344 GLHEDLNRVKKKEYIELRDADGRPDQEVAEEAWRNHLRRNDSVIVDTFHGLFKSTLVCPECNKVS 408

  Fly   198 M--------------------------LPQTQNQPQYQ--------------SLQQ------QQP 216
            :                          |..|....||:              :|.|      .|.
Zfish   409 VTFDPFCYLSVPLPVSKERVMEVFYVSLDPTAKPTQYRLIVPKAGRVLDLCTALSQATGVPPNQM 473

  Fly   217 SETDDEN--------DDEAAPASLSHASESEYDTCESSMSERSAEVLLK---------------- 257
            :.||..|        .||:....|.......|......:.|.|.||:|.
Zfish   474 TVTDVFNHRFYRIYQSDESLSCILDRDDIFVYQLSSGCVDEDSDEVVLSIYMRERSHYRDYGSGS 538

  Fly   258 ----TEYFVTPCR-------------------------------------------------TNG 269
                |..|..|.|                                                 |||
Zfish   539 NSYGTSLFGHPLRMSVPRAHCTPEHLYQLLLERLARYVRPLDPSEEVEEEEEDDEEELYKAQTNG 603

  Fly   270 -----------------------SNSGLPEGHSVQLQQAPLQHQQKNA----SSAEQK---PIEA 304
                                   :::.:.|.::.|.:.:|....::.|    ||:||:   ..|.
Zfish   604 VSDDEGEEDSEEAGSSKKEEEPRASNEVNEQNNGQSEASPSSEGEERAEEEESSSEQERGSSTEE 668

  Fly   305 ARSII--SDVFDGKLLSSV-----------------QCLTCDRVSTREETFQDLSLPIPNRDFLN 350
            .:|..  :|..||...:..                 :..:|...:.|.          |.|....
Zfish   669 GQSACGSTDTTDGDQSAGAEPSGKEEDEDEEEEDGEEAASCTPANKRH----------PGRRRYT 723

  Fly   351 VLHQTHSLSVQSLNAAETSAR-----------TNEGWLSWMW-----------NMLRSWIYGPS- 392
            ...:....::|::|:..|:.|           :::.:::..|           |....:|...|
Zfish   724 ERRKKALFTIQAVNSNGTTERGMAEAGGSISFSSQPYIAIDWDPDMKKKYYNENEAEKYIKHQSM 788

  Fly   393 --------VTLYDCMASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLPEVLCIHLKRFRNDL 449
                    |.|.:|:..|.:.:.|:.:|.:.|..|.:.:...|...:.:|||||.||||||....
Zfish   789 DVPHQQTTVQLQECIELFTTVETLEEENPWYCPTCKRHQLATKKLDLWSLPEVLIIHLKRFSYTK 853

  Fly   450 SYSSKISSDVYFPLEGFDMRPYIHKDCKSEV---AIYNLSSVICHHGTVGGGHYTCFARNTLNGK 511
            ....|:.:.|.|||...|...::.|...:..   ..|:|.||..|:|.:..||||.:|||..||:
Zfish   854 YSREKLDTIVEFPLRDLDFSGFLLKKTVNSTEPPCPYDLISVSNHYGGLRDGHYTSYARNKDNGQ 918

  Fly   512 WYEFDDQFVTEVSSELVQSCQAYVLFYHKHNPQMKLVRDEAMTLSTSHPL-CDSDIQFYITRE 573
            ||.|||..||....|.:.:..||:|||.:        :|:....|...|: |.:..:.:|:.:
Zfish   919 WYYFDDSKVTYAREEQIVTSAAYLLFYQR--------QDKIRQPSVPPPVPCSTQPENHISSQ 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	151/723 (21%)
		Peptidase_C19	80..>204	CDD:271592	49/208 (24%)
		Peptidase_C19R	307..538	CDD:239139	69/283 (24%)
		DUSP	560..643	CDD:197831	3/15 (20%)
		DUSP	667..755	CDD:197831
usp11	XP_002663119.3	UBP12	15..947	CDD:227847	158/742 (21%)
		DUSP	34..119	CDD:283896
		Ubiquitin_3	133..219	CDD:291502
		Peptidase_C19	242..>419	CDD:271592	47/186 (25%)
		USP7_C2	413..>504	CDD:291217	13/90 (14%)
		Peptidase_C19R	<793..946	CDD:239139	54/152 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810