DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp20-33 and usp43a

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_009300631.1	Gene:	usp43a / 563983	ZFINID:	ZDB-GENE-100211-1	Length:	1154	Species:	Danio rerio

Alignment Length:	1208	Identity:	255/1208 - (21%)
Similarity:	395/1208 - (32%)	Gaps:	437/1208 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GDPRSSRCHDKLFSGSLK-SLARREDSNASDSEGTDTAKGSGT-GLVGLQNIANTCYMNSALQAL 98
            ||..|  .|:   ||:.: |.||:..|..|..|......|..| |:.||:|..|||:||:.:|.|
Zfish    73 GDTAS--VHN---SGNYRESSARKSSSYGSVKERLSWCYGEKTPGVQGLKNHGNTCFMNAVVQCL 132

  Fly    99 SNLPPMTHYFINCSDLVEYIAEQSARRCKPGGLAKS----------YRRLMQEIWQDVDDPKEFI 153
            ||...:..|.    .|.:|..|.:.||.  .|:.||          ...|::.:|.:...|:..:
Zfish   133 SNTELLAEYL----GLEQYKYELNERRI--NGMMKSEEVRGEVTDKLASLVRALWTNDYTPQLSV 191

  Fly   154 APRGIL--YGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEE---------------------LTEQ 195
            ..:.::  ||     ..|:|..|||..|||...:|.:||:                     |.|.
Zfish   192 DFKSVVAKYG-----SQFKGNAQHDALEFLLWLLDCVHEDANLSTNNNQSRNSSSSKGSVGLEES 251

  Fly   196 VSMLPQTQNQP-------------QYQS-------LQQQQPSETDDE----------NDDEAAPA 230
            ....|....||             ||:|       |:|   |.|.|.          ....|...
Zfish   252 SCPGPANSQQPGTRHSFVQEHFQAQYRSSLTCPHCLKQ---SNTFDPFLCISLPIPLRQTRALNV 313

  Fly   231 SLSHASESE--------------YDTCESSMSER---SAEVLLKTEYFVTPCRTNGSNSG----- 273
            :|..::|.:              ..|..:.::|.   |.:.::.||          .|||
Zfish   314 TLVFSTEGQRFLRIGLAVPLFGSISTLRAMVAEEGKLSPDQVILTE----------MNSGGFQRS 368

  Fly   274 ---------LPEGHSVQLQQAPLQHQQKNAS--------SAEQKPIEAARSIISDVFDGKLL--- 318
                     :.|...:...|.| .|..:..|        |....|..|.       |.|..|
Zfish   369 FSDEDDMTSISESDVIYAFQVP-PHFTRGGSMRFSGYHHSLPSSPYTAD-------FKGHRLPPS 425

  Fly   319 -------------SSVQCLTCDRVSTREE----------------TFQDLSLPIPNRDFLNVLHQ 354
                         |.|..|.|:...:.::                ::..|...:.|:  |.|..:
Zfish   426 GTLSTEFLNHGGSSKVLLLICNVAGSGQQATRFGPPFLMRVERTLSWDHLQQSVCNK--LYVFQK 488

  Fly   355 THSLSVQSL-NAAETSARTNEGWLS--------------------------------WMWNMLRS 386
            |..:....| .........:..:||                                |. |.::.
Zfish   489 TAIIKTTELFKVRVVGGSASCSYLSPHDSRPLCHPTVDRALKLCGPGGPLHVKLIIEWD-NKIKE 552

  Fly   387 WIYG-----------------------PSVTLYDCMASFFSADELKGDNMYSCERCNKLRTGIKY 428
            .::|                       .|.||.||...:...::|..|:.:.|..|.:::.|:..
Zfish   553 CLFGNIQEEVIEDAESVRIQQQNHVQQHSCTLDDCFQLYTKEEQLAPDDAWKCPHCKQMQQGMVK 617

  Fly   429 SRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHKDCKS--EVA---------- 481
            ..:.|||::|.:||||||......:|:|:.:.||:...||.|::.|..:|  .:|
Zfish   618 MSLWTLPDILILHLKRFRQVGKRRNKLSTLIRFPVSALDMTPHVVKRSQSMKNLAPLPSTWKHGE 682

  Fly   482 ---IYNLSSVICHHGTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELVQSCQAYVLFYHKHNP 543
               :|:|.:|..|||.:.|||||.:.||:::|.||.:||..|..|..|.:.:..||:|||.:.|.
Zfish   683 TDFLYDLYAVCNHHGGMHGGHYTAYCRNSVDGHWYSYDDSSVEIVPEEELCTRGAYILFYQRRNV 747

  Fly   544 QMKLVRDEAMTLSTSHPLCDSDIQFYITREWLSRLATFSEPGP-INNQEMLCPHGGILHSKADVI 607
            ......:.::..|||..:.|         .||.||...|:.|. ::.....||
Zfish   748 IPPWSANSSVRGSTSSSMSD---------HWLIRLNGDSKRGSMVSRSSTTCP------------ 791

  Fly   608 SQIAVPISQPLWDYLYRTFGGGPAVNIIFECEICKRAAETLSRRQQYELNEFTKYNGLQNEFDS- 671
            |.||.....|:       |...|::.            |.:| ...:|...|.:  |:|....|
Zfish   792 SSIADSPESPV-------FKNEPSIE------------ERVS-LGGFESRPFVR--GIQGRSVSM 834

  Fly   672 ---TAIYAIAMPWLRSWQQFSRGKTHKDPGPITNEGIAAPTE--NGSATVSCVRLGSDYAQLNAR 731
               |....:.:.|     .|.....|| |.|.:.:..|...|  .......|.:
Zfish   835 RSPTKSKVLPLRW-----SFGNKDRHK-PVPASEQSPAELVEYLESGRRPRCTK----------- 882

  Fly   732 LWRFLHNIYGGGPEIILRQALSDED-DAE--------------EIEIIDQDDECDDDEDQDLEGE 781
                       .|.:.|....||:| ||:              |...|.|..|....|    :..
Zfish   883 -----------DPIVSLMTRPSDKDNDAKKTAKSSSHSGLRPPEYLKIPQGQERSSSE----KAM 932

  Fly   782 GEDEEIAAASYQ---------------HNHSDTESNLGIRNTPSPSPSTSPSPSLTGTRQPMETE 831
            |:....::.|.:               .:||...|..||:       |:..:||...|.|..|
Zfish   933 GQQPASSSRSREEGTLTRRSSRKSKPDQSHSRKSSGAGIQ-------SSCSTPSGWETAQKHE-- 988

  Fly   832 SDLRPSSSKSKRSRSKMKVSALRLNMRNRGKRNRSAFKQYAEMFGAKGNYNAHSNAEPVVSEKDE 896
                 ||.|..:|..|.|          :|:..    |::......||.:        :..:...
Zfish   989 -----SSDKRDQSEDKHK----------KGQET----KRHDVFAFLKGGF--------IKKDSLR 1026

  Fly   897 KDKDNDRT------VAFPSEYSLPISIPFQSDNFQVNGVHEK------------SRDKGKLRNS- 942
            |.:|||..      |..||..||.            ||.|.|            ||...:|.|.
Zfish  1027 KSRDNDSVKKADSGVKSPSGVSLS------------NGTHNKNPEGKVSTMNHGSRHGSELANGK 1079

  Fly   943 ----------SKSGSTAATKENVTLQKFVTLREANGPS 970
                      |:|.|...:|.::.|::..:|.. ||.|
Zfish  1080 VSRGSSDIKRSQSSSNIQSKTDLGLRRTASLHR-NGTS 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	141/663 (21%)
		Peptidase_C19	80..>204	CDD:271592	40/156 (26%)
		Peptidase_C19R	307..538	CDD:239139	72/333 (22%)
		DUSP	560..643	CDD:197831	15/83 (18%)
		DUSP	667..755	CDD:197831	14/93 (15%)
usp43a	XP_009300631.1	UBP12	<76..746	CDD:227847	156/709 (22%)
		Peptidase_C19	115..>315	CDD:271592	51/213 (24%)
		Peptidase_C19	115..>221	CDD:271592	34/116 (29%)
		Peptidase_C19R	<578..743	CDD:239139	55/164 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910