DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp20-33 and usp33

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001016228.1	Gene:	usp33 / 548982	XenbaseID:	XB-GENE-1016674	Length:	892	Species:	Xenopus tropicalis

Alignment Length:	804	Identity:	323/804 - (40%)
Similarity:	444/804 - (55%)	Gaps:	101/804 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PRSSRCHD------KLFSGSLKSLARREDSNASDSEGTDTAKGSGTGLVGLQNIANTCYMNSALQ 96
            |.|::..|      |:.|.....:.....|...|.|..:..:....||.||:||.||||||:|||
Frog   100 PTSAKLQDSHTQESKMSSSLTLKIPAAVVSENLDIELEEEDELKTRGLTGLKNIGNTCYMNAALQ 164

  Fly    97 ALSNLPPMTHYFINCSDLVEYIAEQSARRCKPGGLAKSYRRLMQEIWQDVDDPKEFIAPRGILYG 161
            ||||.||:||||::|..|        ||..|...|.|||::||.:||.  .:...|:.|..:..|
Frog   165 ALSNCPPLTHYFLDCGGL--------ARTDKKPALCKSYQKLMSDIWH--KNRPGFVIPTNLFQG 219

  Fly   162 IRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTEQVSMLPQTQNQPQYQSLQQQQPSETDDE---- 222
            |::|:|.||||.|.|.||||||.||.|||||.||:..:.:.......:....:..|::|::
Frog   220 IKSVNPTFRGYSQQDAQEFLRCLMDVLHEELKEQIVEVEEDAQTGIVEENLDEDKSQSDNDFHSC 284

  Fly   223 ----NDDEAAPAS------------LSHASESEYDTCESSMSERSAEVLLKTEYFVTPCRTNGSN 271
                :.|.|...|            |.|..:.:.:.|::...|:.....|...:|:.....| ..
Frog   285 DSGSSSDHAESESRKLSEELTESTMLIHEDQKDVEICKTWQKEKKFSNNLNQNHFLQDFEKN-IQ 348

  Fly   272 SGLPEGHSVQLQQAPLQHQQKNA---------------------------SSAEQKP-------- 301
            |.:.|...::.:...:|.|.|.|                           ||:..||
Frog   349 STIEESECLKQETVKVQIQSKAADFTAEVNMNDLPTSQTPLLNEGATTHLSSSPPKPGAVWTGHK 413

  Fly   302 ------------IEAARSIISDVFDGKLLSSVQCLTCDRVSTREETFQDLSLPIPNRDFLNVLH- 353
                        .:...|:|:|:|||.::||||||||||||...|||||||||||.::.|..||
Frog   414 KVPGLCPAKKRKQKKYHSVIADIFDGTIVSSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHS 478

  Fly   354 QTHSLS-VQSLNAAETSARTNEGWLSWMWNMLRSWIYGPSVTLYDCMASFFSADELKGDNMYSCE 417
            .:|..| |::.:..|  |...:||:::.....:||.:||:|||.||:|:||:.||||||||||||
Frog   479 SSHQSSLVKAGSCGE--AYAPQGWIAFFLEYFKSWFWGPTVTLQDCLAAFFARDELKGDNMYSCE 541

  Fly   418 RCNKLRTGIKYSRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHKDCKSEVAI 482
            :|.|||.|:|:.:|...||:|||||||||::|.:|:||.:.|.|||||.|::|::.||..|::..
Frog   542 KCKKLRNGVKFCKVQKFPEILCIHLKRFRHELMFSTKIGTHVSFPLEGLDLQPFLAKDSPSQIVT 606

  Fly   483 YNLSSVICHHGTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELVQSCQAYVLFYHKHNPQ-MK 546
            |:|.||||||||...|||..:.||.||..|||||||.|||||...||:.:||||||.|.:.: .|
Frog   607 YDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSEATVQNAEAYVLFYRKASEEAQK 671

  Fly   547 LVRDEAMTLSTSHPLCDSDIQFYITREWLSRLATFSEPGPINNQEMLCPHGGILHSKADVISQIA 611
            ..|..:..|:...|   |.:||||:|:||::..||:|||||:|.:.||.|||:...||..|..:.
Frog   672 ERRRVSCLLNIMEP---SLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKASFIEDLV 733

  Fly   612 VPISQPLWDYLYRTFGGGPAVNIIFECEICKRAAETLSRRQQYELNEFTKYN-GLQNEFDSTAIY 675
            |.:.|.:|||||..:|||||||.::.|..|:...|.:.:|::.||..|.:.| ..|.|.....||
Frog   734 VMLPQNIWDYLYSRYGGGPAVNHLYVCYTCQTEMEKIEKRRKMELETFIRLNKAFQEEESPAVIY 798

  Fly   676 AIAMPWLRSWQQFSRGKTHKDPGPITNEGIAAPTENGSATVSCVRLGSDYAQLNARLWRFLHNIY 740
            .|:|.|.|.|:.|.:.|....||||.|..||| .:.|..|   :|.|:|..|::...|.||.:||
Frog   799 CISMQWFREWEGFVKSKDSDPPGPIDNTKIAA-AKCGHIT---LRQGADSGQISEETWLFLQSIY 859

  Fly   741 GGGPEIILRQ----ALSDEDDAEE 760
            ||||||.|||    |.|:...|||
Frog   860 GGGPEITLRQNVTLAESEGGHAEE 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	217/527 (41%)
		Peptidase_C19	80..>204	CDD:271592	63/123 (51%)
		Peptidase_C19R	307..538	CDD:239139	131/232 (56%)
		DUSP	560..643	CDD:197831	41/82 (50%)
		DUSP	667..755	CDD:197831	40/91 (44%)
usp33	NP_001016228.1	zf-UBP	30..90	CDD:280334
		UCH	147..662	CDD:278850	217/527 (41%)
		Peptidase_C19	148..>178	CDD:271592	23/29 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..311		5/42 (12%)
		Peptidase_C19R	430..663	CDD:239139	132/234 (56%)
		DUSP	684..764	CDD:197831	40/82 (49%)
		DUSP	790..871	CDD:197831	38/84 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	394	1.000	Domainoid score	I762
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1024
OMA	1	1.010	-	-		QHG46045
OrthoDB	1	1.010	-	-		D147564at2759
OrthoFinder	1	1.000	-	-		FOG0003021
OrthoInspector	1	1.000	-	-		otm48952
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2011
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080