DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp20-33 and usp4

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_002662556.2	Gene:	usp4 / 449927	ZFINID:	ZDB-GENE-041008-187	Length:	1009	Species:	Danio rerio

Alignment Length:	795	Identity:	182/795 - (22%)
Similarity:	273/795 - (34%)	Gaps:	282/795 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VEHRN-------RTIHSSQGHTLANGYAMGDPRSSRCHDKLFSGSLKSLARREDSNAS------- 64
            :|.:|       ::.||....:.:..|......||..     |.::.|.....|||::
Zfish   231 IEKKNEDGTWPRQSCHSKSSTSTSRNYTTSPKPSSNS-----SATISSTITNGDSNSNSGYMLNN 290

  Fly    65 -------------DSEGTDTAKGSGTGLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVE 116
                         .|..:.....:..||.||.|:.|||:||||||.|||.||:|.||:      |
Zfish   291 STSGNRLGSYNSYSSSYSYRESAAQPGLCGLSNLGNTCFMNSALQCLSNTPPLTEYFL------E 349

  Fly   117 YIAEQSARRCKP----GGLAKSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDT 177
            ...|....|..|    |.:|::|..|::::|.   ....::|||.....:....|.|.||||.|:
Zfish   350 DRYEAEINRENPLGMRGEIAEAYADLVKQMWL---SRSSYVAPRTFKTQVGRFAPQFSGYQQQDS 411

  Fly   178 QEFLRCFMDQLHEELT------------------------------------------------- 193
            ||.|...:|.|||:|.
Zfish   412 QELLAFLLDGLHEDLNRVKKKPYLALRDAEGRPDEIVAKEAWANHRLRNDSIIVDIFHGLFKSTL 476

  Fly   194 -----EQVSM-----------LPQTQNQ----------PQYQSLQ-------------------- 212
                 .:||:           ||..:::          ||::::|
Zfish   477 VCPECSKVSVTFDPFCYLTLPLPMKKDRTMEVYLVRTDPQFRAMQFRVVVPKMGAVADLCSALAK 541

  Fly   213 -QQQPSE----TDDEN---------DDEAAPASLSHASESE----YDTCESSMSER--------- 250
             ...|||    .|..|         ||     .|:...|.:    |:..|.. |||
Zfish   542 LSGVPSENMVVADVYNHRFHKIYKRDD-----GLNQIMEKDDIFVYEVLEED-SERMNLPVYFRE 600

  Fly   251 ---------SAEVLLKTEYFVTPCRTNGSNSGLPE------GHSVQLQQAPLQHQQKNA----SS 296
                     |..:|......:|..|.|.:...|.|      |..|:..|..:...:.:|    ||
Zfish   601 RHAKHSGGSSGTMLFGQPLLITVPRLNLTVDTLYERVLERIGRYVKRSQGTITESRASASATSSS 665

  Fly   297 AEQKPIEAARSI----------ISDVFDGKLLS--------SVQCL----TCDRVSTREETFQDL 339
            :.|.| |...|:          .|.|.||...|        |..|.    .||   ..||.....
Zfish   666 SSQSP-ECLASVSSHGTGLSGCSSPVSDGASCSAGSNGSNHSGTCNGPNGVCD---GDEEAMDHQ 726

  Fly   340 SLPIPNRDF-----------------------LNVLHQTHSLS-VQSLNAAETSARTNEGWLSWM 380
            ..|.|....                       .|...:..|.| |.|...|..|:...:|.|..:
Zfish   727 ESPEPENSHSDTVDGEEDSEPENGPNSSGGKSFNSRPKLFSFSMVNSYGTANISSLPFDGNLLKL 791

  Fly   381 ---------W---------------------NMLRSWIYGPSVTLYDCMASFFSADELKGDNMYS 415
                     |                     :||.:.....:|.|.:|:..|.:.:.|...:.:.
Zfish   792 TTHSTVAIDWDSDTKRLCYDDQEAEAYDKHESMLHAQKKKTTVALRECIELFTTMETLGEHDPWY 856

  Fly   416 CERCNKLRTGIKYSRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHKDCKSEV 480
            |..|.|.:...|...:.:||.:|.:|||||..:..:..|:.:.|.||:...:|..:: .|.|::.
Zfish   857 CPTCKKHQQATKKFDLWSLPRILVVHLKRFSYNRCWRDKLDTVVDFPIRDLNMSEFV-CDPKADP 920

  Fly   481 AIYNLSSVICHHGTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELVQSCQAYVLFYHKHNPQM 545
            .||:|.:|..|:|.:||||||.:.:|..:||||.|||..|:..:.:.:.:..||||||.
Zfish   921 YIYDLIAVSNHYGGMGGGHYTAYGKNKADGKWYYFDDSSVSAATEDQIVTKAAYVLFYQ------ 979

  Fly   546 KLVRDEAMTLSTSHP 560
               |.:|.|.|.|.|
Zfish   980 ---RRDADTPSKSPP 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	160/679 (24%)
		Peptidase_C19	80..>204	CDD:271592	51/192 (27%)
		Peptidase_C19R	307..538	CDD:239139	75/306 (25%)
		DUSP	560..643	CDD:197831	1/1 (100%)
		DUSP	667..755	CDD:197831
usp4	XP_002662556.2	UBP12	8..981	CDD:227847	176/783 (22%)
		DUSP	44..141	CDD:197831
		Ubiquitin_3	155..242	CDD:291502	2/10 (20%)
		Peptidase_C19	319..>507	CDD:271592	51/196 (26%)
		USP7_C2	526..>606	CDD:291217	14/85 (16%)
		Peptidase_C19R	<834..979	CDD:239139	50/145 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810