DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp20-33 and Usp11

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001008861.2	Gene:	Usp11 / 408217	RGDID:	1303052	Length:	921	Species:	Rattus norvegicus

Alignment Length:	681	Identity:	158/681 - (23%)
Similarity:	238/681 - (34%)	Gaps:	210/681 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIAEQSARRCKP----GGLAKSYRRL 138
            |:.||.|:.|||:||||||.|||:|.:|.||:|    ..|:.|.:.|  .|    |.||::|..|
  Rat   255 GICGLTNLGNTCFMNSALQCLSNVPQLTEYFLN----NRYLEELNFR--NPLGMKGELAEAYADL 313

  Fly   139 MQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELT-----EQVSM 198
            :::.|...   ...|.|......:......|.||||||:||.|...:|.|||:|.     |.|.:
  Rat   314 VKQTWSGY---HRSIVPNVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVEL 375

  Fly   199 LPQTQNQPQYQSLQQQQPSETDDENDDEAAPASLSHASESEYDTCESS----------------- 246
            .    |......|:..|.:..:.:..:::......|........|...
  Rat   376 C----NGAGRPDLEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPL 436

  Fly   247 --MSERSAEVLL-------KTEYFVTPCRTNGSNSGLPEGHSVQLQQAP--------LQHQQKNA 294
              .|.|..||..       |.|.........|:.|.|....|.....||        ..|:....
  Rat   437 PVCSRRVLEVFFVPMDPRRKPEQHRVVVPKKGNISDLCVALSTHTSVAPDKMIVADVFSHRFYKL 501

  Fly   295 SSAEQ--------------------KPIEAAR--------------------------------- 306
            ...|.                    :|:|.:|
  Rat   502 YQLEDPLSGILDRDDIFVYEVTGRIEPVEGSRDDIVVPVYLRERTPSRDYNNSYYGLILFGHPLL 566

  Fly   307 -SIISDVFDGKLLSSVQCLTCDRVSTR--------------------------EETFQDLSLPIP 344
             |:..|.|..:.|.::......|..|:                          ||..:::|.|..
  Rat   567 VSVPRDRFSWEGLYNILMYRLSRYVTKPTSDDDDGDEKGDENEDEDVEDDSSSEEEKEEMSGPTD 631

  Fly   345 NRD----------------------FLNVLH---------QTHSLSVQSLNAAETSART------ 372
            |..                      ..|.||         :....::|::|:..||.||
  Rat   632 NDGTQESEQEQAGTSSGVTGRCPSLLDNSLHTSQWPPRRRRKQLFTLQTVNSNGTSDRTTSPEEA 696

  Fly   373 -NEGWLSWMWN------------------------MLRSWIYGPSVTLYDCMASFFSADELKGDN 412
             .:.:::..|.                        ||:.   .| |.|.:|:..|.:.:.|:.:|
  Rat   697 QTQPYIAMDWEPEMKRRYYDEVEAEGYVKHDCVGYMLKK---NP-VQLKECIKLFTTVETLEKEN 757

  Fly   413 MYSCERCNKLRTGIKYSRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHKDCK 477
            .:.|..|.:.:...|...:..|||||.||||||........|:.:.|.||:...|...::.|. |
  Rat   758 PWYCSSCKQHQLATKKLDLWMLPEVLIIHLKRFSFSKFSREKLDTLVQFPIRDLDFSEFVIKP-K 821

  Fly   478 SEVA----IYNLSSVICHHGTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELVQSCQAYVLFY 538
            :|.|    .|:|.:|..|:|.:..||||.||.|..:|:|:.|||..|:.|:...::|..||||||
  Rat   822 NESAPDLYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFY 886

  Fly   539 HKHN---PQMKLVRDEAMTLSTSHPLCDSDI 566
            .:.:   .|.:....|..|...|....:|||
  Rat   887 QRQDVGRRQSQTASSETPTSPASSSTPNSDI 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	148/647 (23%)
		Peptidase_C19	80..>204	CDD:271592	49/132 (37%)
		Peptidase_C19R	307..538	CDD:239139	77/322 (24%)
		DUSP	560..643	CDD:197831	3/7 (43%)
		DUSP	667..755	CDD:197831
Usp11	NP_001008861.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		UBP12	23..888	CDD:227847	151/650 (23%)
		DUSP	44..136	CDD:197831
		Ubiquitin_3	154..233	CDD:291502
		Peptidase_C19	<254..>370	CDD:271592	48/123 (39%)
		Peptidase_C19	258..>437	CDD:271592	54/191 (28%)
		USP7_C2	428..>541	CDD:291217	17/112 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	592..697		15/104 (14%)
		Peptidase_C19R	<736..887	CDD:239139	55/152 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	893..921		7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810