DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp20-33 and usp33

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_998392.1	Gene:	usp33 / 406508	ZFINID:	ZDB-GENE-040426-2323	Length:	897	Species:	Danio rerio

Alignment Length:	827	Identity:	323/827 - (39%)
Similarity:	460/827 - (55%)	Gaps:	129/827 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LANGYAMGDPRSSRCHDKLFSGSLKSLARREDSNASDSEGTDTAKGS---GTGLVGLQNIANTCY 90
            |.|......|..:.|.|....||..|| |...:...|....:|.:..   ..||.||:||.||||
Zfish   103 LPNAAKAVSPVQTPCQDLNTPGSPTSL-RVPSAGTCDDLDMETEEEDELRTRGLTGLKNIGNTCY 166

  Fly    91 MNSALQALSNLPPMTHYFINCSDLVEYIAEQSARRCKPGGLAKSYRRLMQEIWQDVDDPKEFIAP 155
            ||:|||||||.||:|.:|:.|..||        :..|...|.|||::|:.::|.  .:...::.|
Zfish   167 MNAALQALSNCPPLTQFFLECGGLV--------KTDKKPALCKSYQKLVTDLWH--KNRNSYVVP 221

  Fly   156 RGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTEQVSMLPQTQNQPQYQSLQQQQPSETD 220
            ..:..||:.|:||||||.|.|:||||||.||||||||.|   ::|:.::..|..::        |
Zfish   222 TNLFQGIKAVNPMFRGYSQQDSQEFLRCLMDQLHEELKE---LIPEPEDPNQAVAM--------D 275

  Fly   221 DENDDEAAPASLSHASESEYDTCES-SMSERS-------------AEVLL-----------KTEY 260
            |..|::      :|:...::.:||| ..|:|:             ||:|:           |.:.
Zfish   276 DSPDED------NHSQSDDFQSCESCGSSDRADNEGPRVPEDINEAEMLMPEQNQNNRDWQKEKN 334

  Fly   261 FVTPCRTNGSNSGLP--------------------------------------------EGHSVQ 281
            .:......||:..|.                                            ||.:.:
Zfish   335 LINNLYRAGSHGDLDKDVDTTSDSRPIISSQGAIKAQGRTSDSEIQVSSTVRPQSPTGNEGITSR 399

  Fly   282 LQQAPLQHQQ-KNASSAEQK-----PIEAAR-----SIISDVFDGKLLSSVQCLTCDRVSTREET 335
            |..:|.:... .|.||..:|     |.:..|     ||||:||||.::||||||||||||...|.
Zfish   400 LSSSPPKSSAWPNLSSTHKKVPMFTPTKTKRQRKYHSIISEVFDGTIVSSVQCLTCDRVSVTLEN 464

  Fly   336 FQDLSLPIPNRDFLNVLH-QTHSLS-VQSLNAAETSARTNEGWLSWMWNMLRSWIYGPSVTLYDC 398
            |||:|||||.::.|..|| .:|..: |::.:..|  |...:||::::...::||.:||.|||.||
Zfish   465 FQDISLPIPGKEDLAKLHSSSHQTALVKAGSCGE--AYAPQGWIAFVMEYIKSWFWGPVVTLQDC 527

  Fly   399 MASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPL 463
            :|:||:.||||||||||||:|.|||.|:|:.:|.:|||:|||||||||::|.:|:||.:.|.|||
Zfish   528 LAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQSLPEILCIHLKRFRHELMFSTKIGTHVSFPL 592

  Fly   464 EGFDMRPYIHKDCKSEVAIYNLSSVICHHGTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELV 528
            ||.:|:|::.||..:....|:|.||||||||...|||..:.||.||..|||||||.|||||...|
Zfish   593 EGLEMQPFLAKDSSALTTTYDLLSVICHHGTASSGHYIAYCRNELNQLWYEFDDQSVTEVSESCV 657

  Fly   529 QSCQAYVLFYHKHNPQMKLVRDEAMTL-STSHPLCDSDIQFYITREWLSRLATFSEPGPINNQEM 592
            |:.:||||||.|.|.:.:..|.:..:| :...|   |.:|||::|:||::..||:|||||:|.:.
Zfish   658 QNAEAYVLFYKKSNDETQKERRKVTSLFNMMEP---SLLQFYVSRQWLNKFKTFAEPGPISNHDF 719

  Fly   593 LCPHGGILHSKADVISQIAVPISQPLWDYLYRTFGGGPAVNIIFECEICKRAAETLSRRQQYELN 657
            ||.||||..:||..|..:.:.|.|.:||:||..:|||||||.::.|..|:...|.|.:|::.||:
Zfish   720 LCAHGGIPPNKATYIDDLVLMIPQNVWDHLYSRYGGGPAVNHLYVCHTCQNEIEKLEKRRKNELD 784

  Fly   658 EFTKYN-GLQNEFDSTAIYAIAMPWLRSWQQFSRGKTHKDPGPITNEGIAAPTENGSATVSCVRL 721
            .|.:.| ..|.|.....||.|:|.|.|.|:.|.:||....||||.|..||. .:||..|   ::.
Zfish   785 MFVRLNKAFQEEESPVVIYCISMQWFREWESFVKGKDIDPPGPIDNSKIAV-NKNGHIT---LKP 845

  Fly   722 GSDYAQLNARLWRFLHNIYGGGPEIILRQALSDED-----DAEEIEI 763
            |:|..|::...|.|||||:||||.:.:|.::|.::     ..|:||:
Zfish   846 GADSGQISEETWNFLHNIHGGGPVVTVRPSVSHQESETSQSEEKIEV 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	217/540 (40%)
		Peptidase_C19	80..>204	CDD:271592	59/123 (48%)
		Peptidase_C19R	307..538	CDD:239139	130/232 (56%)
		DUSP	560..643	CDD:197831	40/82 (49%)
		DUSP	667..755	CDD:197831	36/87 (41%)
usp33	NP_998392.1	zf-UBP	31..91	CDD:280334
		UCH	155..667	CDD:278850	217/540 (40%)
		Peptidase_C19	156..>418	CDD:271592	83/288 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..308		11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..420		10/76 (13%)
		Peptidase_C19R	435..668	CDD:239139	131/234 (56%)
		DUSP	687..769	CDD:197831	39/84 (46%)
		DUSP	795..879	CDD:197831	36/87 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	875..897		4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I782
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	559	1.000	Inparanoid score	I1067
OMA	1	1.010	-	-		QHG46045
OrthoDB	1	1.010	-	-		D147564at2759
OrthoFinder	1	1.000	-	-		FOG0003021
OrthoInspector	1	1.000	-	-		otm26093
orthoMCL	1	0.900	-	-		OOG6_103732
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2011
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840