DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp20-33 and Usp32

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_038941969.1	Gene:	Usp32 / 303394	RGDID:	1306657	Length:	1683	Species:	Rattus norvegicus

Alignment Length:	1018	Identity:	209/1018 - (20%)
Similarity:	341/1018 - (33%)	Gaps:	355/1018 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DSNASDSEGTDTAKGSGTGLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIAEQSAR 124
            :|:..|.....|.||:    .||.|:.|||:|||::|.:||..|:|.|||:...|.|      ..
  Rat   797 NSSKIDRHKVPTEKGA----TGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYE------LN 851

  Fly   125 RCKP----GGLAKSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFM 185
            |..|    |.:||.|..|:||:|...   ::.:||..:.:.|....|.|.|:||.|:||.|...:
  Rat   852 RTNPIGMKGHMAKCYGDLVQELWSGT---QKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLL 913

  Fly   186 DQLHEELTEQVSMLPQTQNQPQYQSLQQQQPSETDDENDDEAAPASLSHASESEYDTCESSMSER 250
            |.|||:|.       :...:| |..|:     ::|...|.|.|..:..:
  Rat   914 DGLHEDLN-------RVHEKP-YVELK-----DSDGRPDWEVAAEAWDN---------------- 949

  Fly   251 SAEVLLKTEYFVTPCRTNGSNSGLPEGHSVQLQQAPLQHQQKNASSAEQKPIEAARSIISDVFDG 315
                                                  |.::|            |||:.|:|.|
  Rat   950 --------------------------------------HLRRN------------RSIVVDLFHG 964

  Fly   316 KLLSSVQCLTCDRVSTREETFQDLSLPIPNRDFLNVLHQTHSLSVQSLNAAETSARTNEGWLSWM 380
            :|.|.|:|.||..:|.|.:.|..||||:|...::::     .::|..|:.. |..|
  Rat   965 QLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHL-----EITVIKLDGT-TPIR--------- 1014

  Fly   381 WNMLRSWIYGPSVTLYDCMASFFSADELKGDNMYS------CERCNKLRTGIKYSRVLTLPEVLC 439
                    ||..:.:               |..|:      .:.|     |:|..::| ..||..
  Rat  1015 --------YGLRLNM---------------DEKYTGLKKQLSDLC-----GLKSEQIL-FAEVHS 1050

  Fly   440 IHLKRFRND-----LSYSSKISS-DVYFPLEGFDMRPYIHKDCKSEVAIYNLSSVICH------- 491
            .::|.|..|     ||.|..:.: ::..|.........|..||.|..:...|.:|..:
  Rat  1051 SNIKNFPQDNQKVRLSVSGFLCAFEIPIPASPVSACSPIQTDCSSSPSTNGLFTVTTNGDLPRPI 1115

  Fly   492 -------HGTVGGGHYTCFARNTLNGKWYEF-DDQFVTEVSSELVQSCQAYVLFYHKHNPQMKLV 548
                   :..|..|.........:||..... ||.|.            .|::..|:     |::
  Rat  1116 FIPNGMPNTVVPCGTEKNATNGIVNGHMPPLPDDPFT------------GYIIAVHR-----KMM 1163

  Fly   549 RDEAMTLSTSH--------PL---CDSDIQFYITRE-------WL--SRLATFSEPGPINNQEM- 592
            |.|...||:..        ||   |...     ||:       |:  ||||:...|...:|...
  Rat  1164 RTELYFLSSQKNRPSLFGMPLIVPCTVH-----TRKKDLYDAVWIQVSRLASPLPPQEASNHAQD 1223

  Fly   593 ------------------------LCP-----HGGILHSKAD--VISQIAVPISQPLWD-----Y 621
                                    .||     .|..:....|  .|....:.:.   ||     .
  Rat  1224 CDDSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIGNACIAVD---WDPTALHL 1285

  Fly   622 LYRTFGGGPAVNIIFECEICKRAAETLSRRQQYE-------LNEFTKYNGL-QNEF---DSTAIY 675
            .|:|    ....::.|.|..::     |||.|.|       |..||....| :||.   .....:
  Rat  1286 RYQT----SQERVVEEHESVEQ-----SRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTH 1341

  Fly   676 AIAMPWLRSWQ------------QFSRGKTHKDPGPITNEGIAAPTENGSATVSCVRLGSDYAQL 728
            .:|...|..|:            ||..|:..|     :.:.:..|.|  |...|...:..|
  Rat  1342 CLATKKLDLWRLPPILIIHLKRFQFVNGRWIK-----SQKIVKFPRE--SFDPSAFLVPRD---- 1395

  Fly   729 NARLWRFLHNIYGGGPEIILRQALSDE-DDAEEIEIIDQDDECDDDEDQDLEGEGEDEEIAAASY 792
                           |.:...:.|:.: ||..|:.|     ...|.:..|::....:|::..:.
  Rat  1396 ---------------PTLCQHKPLTPQGDDVSELPI-----PAGDVKKVDVQNPAGEEDVLLSK- 1439

  Fly   793 QHNHSDTESNLGIRNTPSPSPSTSPSPSLTGTRQPMETESDLRPSSSKSKRSRSKMKVSALRLNM 857
                |.:..:..|.::|..|||:|..   :|...|....|.  |:||.....|:|.::...::..
  Rat  1440 ----SPSSLSANITSSPKGSPSSSRK---SGASCPSSKNSS--PNSSPRTLGRNKGRLRLPQIGS 1495

  Fly   858 RNR---GKRNRSAFK-----QYAEMFGAKGNYNAHSNAEPVVSEKDEKDKDNDRTVAFPSEYSLP 914
            :|:   .|.|..|.:     |..|:.......:....::|              .:..|.::.:.
  Rat  1496 KNKLSSSKENLDASRENGAGQICELADTLNRGHVLGGSQP--------------ELVTPLDHEIT 1546

  Fly   915 ISIPFQSDNFQVNGVHE---KSRDKGKLRNSSKSGSTAATKEN 954
            ::..|..:       ||   .....|:|.|.|:..||...:|:
  Rat  1547 LANGFLYE-------HETCGNGYSNGQLGNHSEEDSTDDQRED 1582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	110/489 (22%)
		Peptidase_C19	80..>204	CDD:271592	46/127 (36%)
		Peptidase_C19R	307..538	CDD:239139	54/257 (21%)
		DUSP	560..643	CDD:197831	23/131 (18%)
		DUSP	667..755	CDD:197831	16/102 (16%)
Usp32	XP_038941969.1	FRQ1	254..404	CDD:227455
		UBP12	583..1395	CDD:227847	166/774 (21%)
		UCH	<1314..1643	CDD:395355	60/331 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900